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  1. The effect of centrifugation time of heparinized blood samples on clinical chemistry and immunology results has rarely been studied. WHO guideline proposed a 15 min centrifugation time without citing any scien...

    Authors: Elisabeth I Minder, Adrian Schibli, Dagmar Mahrer, Predrag Nesic and Kathrin Plüer
    Citation: BMC Clinical Pathology 2011 11:6
  2. In resource poor settings where automated hematology analyzers are not available, the Cyanmethemoglobin method is often used. This method though cheaper, takes more time. In blood donations, the semi-quantitat...

    Authors: Bernard Nkrumah, Samuel Blay Nguah, Nimako Sarpong, Denise Dekker, Ali Idriss, Juergen May and Yaw Adu-Sarkodie
    Citation: BMC Clinical Pathology 2011 11:5
  3. Odontogenic cysts are those which arise from the epithelium associated with the development of teeth. Some odontogenic cysts were found to have special biological features that make them distinct from other le...

    Authors: Mohamed S Ayoub, Houry M Baghdadi and Moataz El-Kholy
    Citation: BMC Clinical Pathology 2011 11:4
  4. The aim of the study was to develop a virtual microscopy enabled method for assessment of Ki-67 expression and to study the prognostic value of the automated analysis in a comprehensive series of patients with...

    Authors: Juho Konsti, Mikael Lundin, Heikki Joensuu, Tiina Lehtimäki, Harri Sihto, Kaija Holli, Taina Turpeenniemi-Hujanen, Vesa Kataja, Liisa Sailas, Jorma Isola and Johan Lundin
    Citation: BMC Clinical Pathology 2011 11:3
  5. Frozen storage often precedes metagenomic analysis of biological samples; however, the freezing process can have adverse effects on microbial composition. The effect of freezing on the detection of bacteria in...

    Authors: Brenda A Kwambana, Nuredin I Mohammed, David Jeffries, Mike Barer, Richard A Adegbola and Martin Antonio
    Citation: BMC Clinical Pathology 2011 11:2
  6. Some members of the Protein 4.1 superfamily are believed to be involved in cell proliferation and growth, or in the regulation of these processes. While the expression levels of two members of this family, rad...

    Authors: Tanner L Bartholow, Uma R Chandran, Michael J Becich and Anil V Parwani
    Citation: BMC Clinical Pathology 2011 11:1
  7. KRAS mutational analysis is the standard of care prior to initiation of treatments targeting the epidermal growth factor receptor (EGFR) in patients with metastatic colorectal cancer. Sensitive methods are requi...

    Authors: Colin C Pritchard, Laura Akagi, Poluru L Reddy, Loren Joseph and Jonathan F Tait
    Citation: BMC Clinical Pathology 2010 10:6
  8. Drug resistance levels and patterns among Mycobacterium tuberculosis isolates from newly diagnosed and previously treated tuberculosis patients in Mbarara Uganda were investigated.

    Authors: Joel Bazira, Benon B Asiimwe, Moses L Joloba, Fred Bwanga and Mecky I Matee
    Citation: BMC Clinical Pathology 2010 10:5
  9. Oxidative stress plays an important role in the course and eventual outcome in a majority of patients admitted to the intensive care unit (ICU). Markers to estimate oxidative stress are not readily available i...

    Authors: Wendela L Greven, Jitty M Smit, Johannes H Rommes and Peter E Spronk
    Citation: BMC Clinical Pathology 2010 10:4
  10. This study was designed to determine the correlation between heamatological parameters by Sysmex KX-21N automated hematology analyzer with the manual methods.

    Authors: Samuel O Ike, Thomas Nubila, Ernest O Ukaejiofo, Imelda N Nubila, Elvis N Shu and Ifeyinwa Ezema
    Citation: BMC Clinical Pathology 2010 10:3
  11. Histologic samples all funnel through the H&E microtomy staining area. Here manual processes intersect with semi-automated processes creating a bottleneck. We compare alternate work processes in anatomic patho...

    Authors: Lewis A Hassell, Crystal F Glass, Clinton Yip and Patricia A Eneff
    Citation: BMC Clinical Pathology 2010 10:2
  12. SNAI1 can initiate epithelial-mesenchymal transition (EMT), leading to loss of epithelial characteristics and, in cancer, to invasion and metastasis. We hypothesized that SNAI1 reactivation occurs in oral squa...

    Authors: Joerg Schwock, Grace Bradley, James C Ho, Bayardo Perez-Ordonez, David W Hedley, Jonathan C Irish and William R Geddie
    Citation: BMC Clinical Pathology 2010 10:1
  13. Non Hodgkin lymphomas are the most common lymphomas in Uganda. Recent studies from developed countries have shown differences in survival for the different immunophenotypes. Such studies are lacking in Africa ...

    Authors: Lynnette K Tumwine, Claudio Agostinelli, Cristina Campidelli, Emmanuel Othieno, Henry Wabinga, Simona Righi, Brunangelo Falini, Pier Paolo Piccaluga, Wilson Byarugaba and Stefano A Pileri
    Citation: BMC Clinical Pathology 2009 9:11
  14. Determination of the plasma concentrations of arginine and other amino acids is important for understanding pathophysiology, immunopathology and nutritional supplementation in human disease. Delays in processi...

    Authors: Joshua S Davis, Christabelle J Darcy, Kim Piera, Yvette R McNeil, Tonia Woodberry and Nicholas M Anstey
    Citation: BMC Clinical Pathology 2009 9:10
  15. Clear cell renal cell carcinoma (ccRCC) and chromophobe renal cell carcinoma (chRCC) can usually be distinguished by histologic characteristics. Occasionally, diagnosis proves challenging and diagnostic diffic...

    Authors: Ariel A Williams, John PT Higgins, Hongjuan Zhao, Börje Ljungberg and James D Brooks
    Citation: BMC Clinical Pathology 2009 9:9
  16. KRAS mutations represent key alterations in colorectal cancer development and lead to constitutive EGFR signaling. Since EGFR inhibition represents a therapeutic strategy in advanced colorectal cancer, KRAS muta...

    Authors: Mats Jönsson, Anna Ekstrand, Thomas Edekling, Jakob Eberhard, Dorthe Grabau, David Borg and Mef Nilbert
    Citation: BMC Clinical Pathology 2009 9:8
  17. Nephropathy is serious complication of diabetes. We have previously shown that level of the proteoglycan syndecan-1 in blood is associated with ultrastructural kidney changes in young persons with type 1 diabe...

    Authors: Sedegheh Gharagozlian, Katja Svennevig, Hans-Jacob Bangstad, Jan-Olof Winberg and Svein Olav Kolset
    Citation: BMC Clinical Pathology 2009 9:7
  18. The members of the retinoblastoma protein family, pRb, p107 and pRb2 (p130), are central players in controlling the cell cycle. Whereas disturbed function of pRb is commonly seen in human cancers, it is still ...

    Authors: Sam Kalungi, Solrun J Steine, Henry Wabinga, Leif Bostad and Anders Molven
    Citation: BMC Clinical Pathology 2009 9:6
  19. Elevated levels of FMR1 mRNA in blood have been implicated in RNA toxicity associated with a number of clinical conditions. Due to the extensive inter-sample variation in the time lapse between the blood colle...

    Authors: David E Godler, Danuta Z Loesch, Richard Huggins, Lavinia Gordon, Howard R Slater, Freya Gehling, Trent Burgess and KH Andy Choo
    Citation: BMC Clinical Pathology 2009 9:5
  20. In muscle cytochrome oxidase (COX) negative fibers (mitochondrial mosaics) have often been visualized.

    Authors: Frank Roels, Patrick Verloo, François Eyskens, Baudouin François, Sara Seneca, Boel De Paepe, Jean-Jacques Martin, Valerie Meersschaut, Marleen Praet, Emmanuel Scalais, Marc Espeel, Joél Smet, Gert Van Goethem and Rudy Van Coster
    Citation: BMC Clinical Pathology 2009 9:4
  21. Russia is a high tuberculosis (TB) burden country with a high prevalence of multidrug resistant tuberculosis (MDRTB). Molecular assays for detection of MDRTB on clinical specimens are not widely available in R...

    Authors: Vladyslav Nikolayevskyy, Yanina Balabanova, Tatyana Simak, Nadezhda Malomanova, Ivan Fedorin and Francis Drobniewski
    Citation: BMC Clinical Pathology 2009 9:2
  22. Little information is available on the molecular epidemiology in Mexico of Mycobacterium species infecting extrapulmonary sites in humans. This study used molecular methods to determine the Mycobacterium species ...

    Authors: Cosme Alvarado-Esquivel, Nora García-Corral, David Carrero-Dominguez, José Antonio Enciso-Moreno, Teodoro Gurrola-Morales, Leopoldo Portillo-Gómez, Rudi Rossau and Wouter Mijs
    Citation: BMC Clinical Pathology 2009 9:1
  23. Monoclonal gammopathy of undetermined significance (MGUS) is a common plasma cell dyscrasia, comprising the most indolent form of monoclonal gammopathy. However, approximately 25% of MGUS cases ultimately prog...

    Authors: Horatiu Olteanu, Huan-You Wang, Weina Chen, Robert W McKenna and Nitin J Karandikar
    Citation: BMC Clinical Pathology 2008 8:13
  24. Previously published equations to adjust calcium for albumin concentration may vary depending on factors such as the type of reagents used. Albumin-adjusted calcium equations derived from laboratories using th...

    Authors: Matthew T James, Jianguo Zhang, Andrew W Lyon and Brenda R Hemmelgarn
    Citation: BMC Clinical Pathology 2008 8:12
  25. External quality assurance (EQA) is an extremely valuable resource for clinical pathologists to maintain high standards, improve diagnostic skills, and possibly revalidate medical license. The aim of this stud...

    Authors: Consolato Sergi and Gregor Mikuz
    Citation: BMC Clinical Pathology 2008 8:11
  26. Catheters are the most common cause of nosocomial infections and are associated with increased risk of mortality, length of hospital stay and cost. Prevention of infections and fast and correct diagnosis is hi...

    Authors: Mette KS Larsen, Trine R Thomsen, Claus Moser, Niels Høiby and Per H Nielsen
    Citation: BMC Clinical Pathology 2008 8:10
  27. Histopathologic evaluation of surgical specimens is a well established technique for disease identification, and has remained relatively unchanged since its clinical introduction. Although it is essential for ...

    Authors: Benjamin Bird, Milos Miljkovic, Melissa J Romeo, Jennifer Smith, Nicholas Stone, Michael W George and Max Diem
    Citation: BMC Clinical Pathology 2008 8:8
  28. Kaposi sarcoma (KS) flare may occur following therapy with corticosteroids, as part of the immune reconstitution inflammatory syndrome seen with highly active antiretroviral therapy (HAART), and after rituxima...

    Authors: Liron Pantanowitz, Klaus Früh, Sharon Marconi, Ashlee V Moses and Bruce J Dezube
    Citation: BMC Clinical Pathology 2008 8:7
  29. Today, no objective criteria exist to differentiate between individual primary tumors and intra- or intermammary dissemination respectively, in patients diagnosed with two or more synchronous breast cancers. T...

    Authors: Sara Brommesson, Göran Jönsson, Carina Strand, Dorthe Grabau, Per Malmström, Markus Ringnér, Mårten Fernö and Ingrid Hedenfalk
    Citation: BMC Clinical Pathology 2008 8:6
  30. The purpose of this study was to compare DNA histograms obtained by standard flow cytometry (FC) and high fidelity image cytometry on sections (ICS) in normal gastrointestinal mucosa and Barrett's adenocarcino...

    Authors: Qin Huang, Chenggong Yu, Xiaoqi Zhang and Raj K Goyal
    Citation: BMC Clinical Pathology 2008 8:5
  31. Testing for Borrelia-specific IgM and IgG-antibodies are often performed on a variety of poorly defined symptoms, and isolated IgM results are a frequent finding, which results in diagnostic uncertainty and furth...

    Authors: Eskild Petersen, Martin Tolstrup, Francesco Capuano and Svend Ellermann-Eriksen
    Citation: BMC Clinical Pathology 2008 8:4
  32. Predisposition to venous thrombosis may be assessed through testing for defects and/or deficiencies of a number of hereditary factors. There is potential for confusion about which of these tests are appropriat...

    Authors: Brian R Jackson, Kyland Holmes, Amit Phansalkar and George M Rodgers
    Citation: BMC Clinical Pathology 2008 8:3
  33. S100P is a Ca2+ binding protein overexpressed in a variety of cancers, and thus, has been considered a potential tumor biomarker. Very little has been studied about its normal expression and functions.

    Authors: Seppo Parkkila, Pei-wen Pan, Aoife Ward, Adriana Gibadulinova, Ingrid Oveckova, Silvia Pastorekova, Jaromir Pastorek, Alejandra Rodriguez Martinez, Henrik O Helin and Jorma Isola
    Citation: BMC Clinical Pathology 2008 8:2
  34. The potential problems associated with the use of formalin in histology, such as health hazards, degradation of RNA and cross-linking of proteins are well recognized. We describe the utilization of a formalin-...

    Authors: Mehdi Nassiri, Sharon Ramos, Hajir Zohourian, Vladimir Vincek, Azorides R Morales and Mehrdad Nadji
    Citation: BMC Clinical Pathology 2008 8:1
  35. Biomarker-based assessments of biological samples are widespread in clinical, pre-clinical, and epidemiological investigations. We previously developed serum metabolomic profiles assessed by HPLC-separations c...

    Authors: Yevgeniya I Shurubor, Wayne R Matson, Walter C Willett, Susan E Hankinson and Bruce S Kristal
    Citation: BMC Clinical Pathology 2007 7:9
  36. HIV testing on sputum using the QraQuick HIV1/2® assay has high sensitivity and specificity, and holds promise for application in tuberculosis surveys. Its performance under conditions that may occur during surve...

    Authors: Saidi M Egwaga, Timothy M Chonde, Mecky I Matee, Sayoki G Mfinanga, Prosper E Ngowi, Fred Lwilla and Frank GJ Cobelens
    Citation: BMC Clinical Pathology 2007 7:8
  37. Identifying the influence formalin fixation has on RNA integrity and recovery from clinical tissue specimens is integral to determining the utility of using archival tissue blocks in future molecular studies. ...

    Authors: Wilfrido D Mojica, Leighton Stein and Lesleyann Hawthorn
    Citation: BMC Clinical Pathology 2007 7:7
  38. It is well recognised that there is often a disparity between the structural changes observed in the kidney following renal injury and the function of the organ. For this reason, we carried out studies to expl...

    Authors: S Tagboto and A Paul Griffiths
    Citation: BMC Clinical Pathology 2007 7:5
  39. Human papillomavirus (HPV) 16 and 18 are associated with cervical carcinogenesis through an interaction between HPV oncogenic proteins and cell cycle regulatory genes. However, the exact pathogenetic mechanism...

    Authors: Abeer A Bahnassy, Abdel Rahman N Zekri, Maha Saleh, Mohammad Lotayef, Manar Moneir and Osama Shawki
    Citation: BMC Clinical Pathology 2007 7:4
  40. Fine needle aspiration biopsy (FNAB) cytology has been a highly effective methodology for tissue diagnosis and for various ancillary studies including molecular tests. In addition to other benefits, FNAB predo...

    Authors: Vinod B Shidham, Ashwini W Pandit, R Nagarjun Rao, Zainab Basir and Anjani Shidham
    Citation: BMC Clinical Pathology 2007 7:2
  41. Chronic granulomatous disease (CGD) is an inherited disorder of phagocytic cells caused by an inability to generate active microbicidal oxygen species required kill certain types of fungi and bacteria. This le...

    Authors: Andrew PC Mclean-Tooke, Catherine Aldridge, Kimberley Gilmour, Bernard Higgins, Mark Hudson and Gavin P Spickett
    Citation: BMC Clinical Pathology 2007 7:1
  42. Traditional multiplexed gene expression methods require well preserved, intact RNA. Such specimens are difficult to acquire in clinical practice where formalin fixation is the standard procedure for processing...

    Authors: Andrew C Haller, Deepa Kanakapalli, Rosemarie Walter, Samir Alhasan, James F Eliason and Richard B Everson
    Citation: BMC Clinical Pathology 2006 6:9
  43. Synchronous presentation of more than one germ cell tumours of different histology in the same patient is considered to be very rare. In these cases of multiple germ cell tumours, strong theoretical and clinic...

    Authors: Giannis Mountzios, George Pavlakis, Evangelos Terpos, George Sakorafas, Kyriakos Revelos, Aristotelis Bamias, Nikolaos Nikolaou, Pantelis Papasavas, Jean-Charles Soria and Meletios-Athanasios Dimopoulos
    Citation: BMC Clinical Pathology 2006 6:8