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  1. Content type: Research article

    Studies on malignant melanoma have largely focused on Caucasian populations due to higher incidence in lighter-skinned individuals. While there is a well developed body of literature describing melanoma in Afr...

    Authors: Maurice Mulenga, Nathan D. Montgomery, Maganizo Chagomerana, Tenganawo Mzumala, Tamiwe Tomoka, Coxcilly Kampani, Yuri Fedoriw, Satish Gopal and Lisbet Sviland

    Citation: BMC Clinical Pathology 2019 19:5

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  2. Content type: Research article

    Serum cystatin C (SCysC) and serum creatinine (SCr) are two biomarkers used in common practice to estimate the glomerular filtration rate (GFR). For SCysC and SCr to be used in a given population, normal value...

    Authors: Bertille Elodie Edinga-Melenge, Adrienne Tchapmi Yakam, Jobert Richie Nansseu, Catherine Bilong, Suzanne Belinga, Eric Minkala, Prisca Armel Noudjeu, Michel Ondhoua, Samuel Walter Kokola, Vicky Joceline Ama Moor and Gloria Ashuntantang

    Citation: BMC Clinical Pathology 2019 19:4

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  3. Content type: Research article

    EGFR and HER2 overexpression has been reported to play important roles in colorectal cancer (CRC) development and metastasis. Ovarian metastasis is rare yet is one of the most malignant metastases of CRC, but ...

    Authors: Ji-Lin Li, Shu-Han Lin, Hong-Qiu Chen, Li-Sheng Liang, Xian-Wei Mo, Hao Lai, Jie Zhang, Jing Xu, Bing-Qian Gao, Yan Feng and Yuan Lin

    Citation: BMC Clinical Pathology 2019 19:3

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  4. Content type: Research article

    Vilazodone is an FDA approved medication used to treat major depressive disorder. The authors describe two cases of accidental vilazodone exposure in toddlers who presented with symptoms similar to amphetamine...

    Authors: Christina D. Martinez-Brokaw, Joshua B. Radke, Joshua G. Pierce, Alexandra Ehlers, Sean Ekins, Kelly E. Wood, Jon Maakestad, Jacqueline A. Rymer, Kenichi Tamama and Matthew D. Krasowski

    Citation: BMC Clinical Pathology 2019 19:2

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  5. Content type: Research article

    The overexpression of HER2 is associated with worse prognosis of breast cancer which responds favourably to anti-HER2 therapy. The objective of this study was to determine the frequency of HER2 and its associa...

    Authors: Nguiessan Alphonse Aman, Brahima Doukoure, Kouadio Donatien Koffi, Baumaney Sylvanus Koui, Zie Cheick Traore, Mohamed Kouyate and Ahoua Benjamin Effi

    Citation: BMC Clinical Pathology 2019 19:1

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  6. Content type: Research article

    The development of molecular techniques to estimate the risk of breast cancer recurrence has been a significant addition to the suite of tools available to pathologists and breast oncologists. It has previousl...

    Authors: Mark D. Zarella, Rebecca C. Heintzelman, Nikolay K. Popnikolov and Fernando U. Garcia

    Citation: BMC Clinical Pathology 2018 18:14

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  7. Content type: Research article

    Advanced gastric cancers are usually associated with incurable conditions for which systemic treatments are indicated. Recent studies suggest that circulating cell-free plasma DNA of tumour origin (tDNA) is a ...

    Authors: Sávia Raquel Costa Normando, Pamela de Oliveira Delgado, Ana Katherine Soares Barbosa Rodrigues, Waldec Jorge David Filho, Fernando Luiz Affonso Fonseca, Felipe José Silva Melo Cruz and Auro del Giglio

    Citation: BMC Clinical Pathology 2018 18:12

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  8. Content type: Research article

    to evaluate the intraobserver and interobserver reproducibility of cervical cytopathology according to previous knowledge of whether patients received radiotherapy (RT) treatment or not.

    Authors: Fernanda A. Lucena, Ricardo F. A. Costa, Maira D. Stein, Carlos E. M. C. Andrade, Geórgia F. Cintra, Marcelo A. Vieira, Rozany M. Dufloth, José Humberto T. G. Fregnani and Ricardo dos Reis

    Citation: BMC Clinical Pathology 2018 18:11

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  9. Content type: Case report

    Low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is distinctly rare. We report a patient with a uniquely biphasic LGNPPA; additionally, we review similar tumors reported in the literature.

    Authors: Hidenori Yokoi, Yuichi Terado, Masachika Fujiwara, Yuma Matsumoto, Tetsuya Ikeda and Koichiro Saito

    Citation: BMC Clinical Pathology 2018 18:10

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  10. Content type: Research article

    p16 and p53 genes are frequently mutated in triple negative breast cancer & prognostic value of these mutations have been shown; however, their role as immunohistochemical overexpression has not been fully val...

    Authors: Atif Ali Hashmi, Samreen Naz, Shumaila Kanwal Hashmi, Zubaida Fida Hussain, Muhammad Irfan, Erum Yousuf Khan, Naveen Faridi, Amir Khan and Muhammad Muzzammil Edhi

    Citation: BMC Clinical Pathology 2018 18:9

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  11. Content type: Research article

    The identification of implant wear particles and non-implant related particles and the characterization of the inflammatory responses in the periprosthetic neo-synovial membrane, bone, and the synovial-like in...

    Authors: G. Perino, S. Sunitsch, M. Huber, D. Ramirez, J. Gallo, J. Vaculova, S. Natu, J. P. Kretzer, S. Müller, P. Thomas, M. Thomsen, M. G. Krukemeyer, H. Resch, T. Hügle, W. Waldstein, F. Böettner…

    Citation: BMC Clinical Pathology 2018 18:7

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  12. Content type: Case report

    In lacrimal gland, lymphomas and inflammatory lesions predominate. Primary epithelial tumours represent less than 30% of lacrimal gland lesions. Myoepithelial carcinoma of lacrimal gland is rare. To the best o...

    Authors: Youssef Mahdi, Mohamed Amine Azami, Rajae Daoudi and Nadia Cherradi

    Citation: BMC Clinical Pathology 2018 18:6

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  13. Content type: Case report

    Chronic lymphocytic leukemia (CLL) is a mature lymphoid neoplasm currently categorized as an indolent type of malignant lymphoma. CLL progresses slowly over years, but it eventually transforms to a more aggres...

    Authors: Osamu Imataki and Makiko Uemura

    Citation: BMC Clinical Pathology 2018 18:5

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  14. Content type: Research article

    Helicobacter pylori antibody titters fall very slowly even after successful treatment. Therefore, tests detecting H. pylori antibody lack specificity and sensitivity. On the other hand, H. pylori stool antigen te...

    Authors: Markos Negash, Afework Kassu, Bemnet Amare, Gizachew Yismaw and Beyene Moges

    Citation: BMC Clinical Pathology 2018 18:4

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  15. Content type: Case report

    Primary hepatic neuroendocrine carcinoma (PHNEC) is extremely rare. The diagnosis of PHNEC remains challenging—partly due to its rarity, and partly due to its lack of unique clinical features. Available treatm...

    Authors: Zi-Ming Zhao, Jin Wang, Ugochukwu C. Ugwuowo, Liming Wang and Jeffrey P. Townsend

    Citation: BMC Clinical Pathology 2018 18:3

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  16. Content type: Research article

    Gastrointestinal stromal tumors (GIST) are the most common primary mesenchymal tumors of the digestive system. The assessment of their biological behavior still remains a scientific challenge. To date, there a...

    Authors: Boubacar Efared, Gabrielle Atsame-Ebang, Layla Tahiri, Ibrahim Sory Sidibé, Fatimazahra Erregad, Nawal Hammas, Samia Arifi, Ihsane Mellouki, Abdelmalek Ousadden, Khalid Mazaz, Hinde El Fatemi and Laila Chbani

    Citation: BMC Clinical Pathology 2018 18:2

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  17. Content type: Research article

    Measuring expression profiles of inflammatory biomarkers is important in monitoring the polarization of immune responses; therefore, results should be independent of quantitation methods if they are to be acce...

    Authors: Alain Stricker-Krongrad, Catherine Shoemake, Miao Zhong, Jason Liu and Guy Bouchard

    Citation: BMC Clinical Pathology 2018 18:1

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  18. Content type: Research article

    The only potentially curative therapy for myelodysplastic syndrome is allogeneic hematopoietic cell transplant; unfortunately, there is a high relapse rate. The objective of this study was to perform a detaile...

    Authors: Elizabeth L. Courville, Megan Griffith, Celalettin Ustun, Sophia Yohe and Erica Warlick

    Citation: BMC Clinical Pathology 2017 17:28

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  19. Content type: Research article

    Endometrial cancer (EC) is a major health concern due to its rising incidence. Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis with limited treatment options. Altered...

    Authors: Ayşe Latif, Amy L. Chadwick, Sarah J. Kitson, Hannah J. Gregson, Vanitha N. Sivalingam, James Bolton, Rhona J. McVey, Stephen A. Roberts, Kay M. Marshall, Kaye J. Williams, Ian J. Stratford and Emma J. Crosbie

    Citation: BMC Clinical Pathology 2017 17:27

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  20. Content type: Research article

    The global prevalence of type 2 diabetes is increasing. Dyslipidaemia is a known complication of diabetes mellitus manifesting frequently as cardiovascular diseases and stoke. Elevation of small, dense low den...

    Authors: Kenneth O. Inaku, Obasola O. Ogunkeye, Fayeofori M. Abbiyesuku, Evelyn K. Chuhwak, Christian O. Isichei, Lucius C. Imoh, Noel O. Amadu and Alexander O. Abu

    Citation: BMC Clinical Pathology 2017 17:26

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  21. Content type: Research article

    Intraoperative consultation is an important tool for the evaluation of the upper aerodigestive tract (UAT) malignancies. Although frozen section analysis is a preferred method of intra-operative consultation, ...

    Authors: Hania Naveed, Mariam Abid, Atif Ali Hashmi, Muhammad Muzammamil Edhi, Ahmareen Khalid Sheikh, Ghazala Mudassir and Amir Khan

    Citation: BMC Clinical Pathology 2017 17:25

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  22. Content type: Case report

    Lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. It is extremely rare in the larynx and should be distinguished...

    Authors: Nawal Hammas, Najib Benmansour, Mohamed Nour-dine El Alami El Amine, Laila Chbani and Hind El Fatemi

    Citation: BMC Clinical Pathology 2017 17:24

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  23. Content type: Case report

    Medulloepithelioma is a rare primitive neuroectodermal tumor of the central nervous system, usually developing in childhood. Due to its rarity, the optimal management is still unknown. The prognosis is poor, e...

    Authors: Nezha Oumghar, Fatima Ezzahra Hazmiri, Abdelhamid El Omrani, Hanane Rais and Mouna Khouchani

    Citation: BMC Clinical Pathology 2017 17:23

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  24. Content type: Case report

    Solitary fibrous tumor is an uncommon spindle cell neoplasm of unknown origin. It has been reported in many anatomic sites, with a rare occurrence in the head and neck region. Solitary fibrous tumors of the pa...

    Authors: Meryem Rais, Amine Kessab, Zahra Sayad, Sanae El Mourabit, Redallah Zrarqi, Salma Benazzou, Malik Boulaadas and Nadia Cherradi

    Citation: BMC Clinical Pathology 2017 17:22

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  25. Content type: Case report

    B-cell lymphomas harboring the 8q24/MYC plus 18q21/BCL2 translocations are now referred to as high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-MBR). Although HGBL-MBR is frequently fo...

    Authors: Akiko Uchida, Yasushi Isobe, Yu Uemura, Yuji Nishio, Hirotaka Sakai, Masayuki Kato, Kaori Otsubo, Masahiro Hoshikawa, Masayuki Takagi and Ikuo Miura

    Citation: BMC Clinical Pathology 2017 17:21

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  26. Content type: Case report

    Primary hyperoxaluria is a rare disease with an estimated prevalence of 1 to 3 cases per million. It is due to a hepatic enzyme deficiency responsible for an endogenous overproduction of oxalate. Oxalate cryst...

    Authors: F. Nachite, M. Dref, A. Fakhri and H. Rais

    Citation: BMC Clinical Pathology 2017 17:20

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  27. Content type: Research article

    Mosquito coil (MC) emits insecticide upon burning which provides limited protection against lethal mosquito borne diseases. However, apart from killing the insect, toxicities associated with the inhalation of ...

    Authors: M. Abdulla Al-Mamun, M. Ataur Rahman, M. Habibur Rahman, K.M.F. Hoque, Z. Ferdousi, Mohammad Nurul Matin and M. Abu Reza

    Citation: BMC Clinical Pathology 2017 17:19

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  28. Content type: Research article

    Cervical cancer can be prevented by early detection and treatment for precancerous lesions. Since 1995, there has been a national cervical cancer screening program in Norway, where women aged 25–69 years are r...

    Authors: Sveinung Wergeland Sørbye, Pål Suhrke, Berit Wallem Revå, Jannicke Berland, Ramona Johansen Maurseth and Khalid Al-Shibli

    Citation: BMC Clinical Pathology 2017 17:18

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  29. Content type: Case report

    Primary breast angiosarcoma is defined as malignant proliferation showing endothelial differentiation. It is a very rare tumour (0.05% of primary mammary cancers), whose diagnosis can be difficult.

    Authors: Fayçal Abbad, Najat Cherif Idrissi, Btissam Fatih, Bouchra Fakhir, Jamal Drissi, Mouna Khouchani and Hanane Rais

    Citation: BMC Clinical Pathology 2017 17:17

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  30. Content type: Case report

    Ovarian sarcomas represent less than 1% of all ovary cancers and usually are frequent in adults. Primary angiosarcomas are exceptional in the ovaries within children.

    Authors: Tchin Darré, Abdoul-Samadou Aboubakari, Bingo K. N’Bortche, Akila Bassowa, Solange Adani-Ifé and Gado Napo-Koura

    Citation: BMC Clinical Pathology 2017 17:16

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  31. Content type: Research article

    Lumbar puncture with quantification of leukocytes and differential count of cellular subsets in the cerebrospinal fluid is a standard procedure in cases of suspected neuroinfectious conditions. However, a numb...

    Authors: Anne Ahrens Østergaard, Thomas Vognbjerg Sydenham, Mads Nybo and Åse Bengård Andersen

    Citation: BMC Clinical Pathology 2017 17:15

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  32. Content type: Research article

    Platelets and coagulation proteins contribute to the development of peripheral arterial disease, especially atherosclerotic disease. Several experimental studies have proven a significant correlation between h...

    Authors: Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku and Yoshinori Inoue

    Citation: BMC Clinical Pathology 2017 17:14

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  33. Content type: Case report

    Malignant Deciduoid Mesothelioma (MDM) is an extremely rare variant of epithelioid mesothelioma. It was first described in young females, in the peritoneum, and its relation with asbestos was not well defined.

    Authors: Mouna Khmou, Soumiya Echcharif, Rachad Kabbaj and Basma El Khannoussi

    Citation: BMC Clinical Pathology 2017 17:13

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  34. Content type: Case report

    Inflammatory myofibroblastic tumour (IMT) is a mesenchymal neoplasm of intermediate biological potential that may affect a wide range of anatomic sites but has a particular predilection for the lung and intra-...

    Authors: Adil Boudhas, Mohamed Allaoui, Fouad El Asri, Issam Rharrassi, Mohamed Reda El Ochi, Mohamed Tbouda, Hafsa Chahdi, Abderrahmane Al Bouzidi and Mohamed Oukabli

    Citation: BMC Clinical Pathology 2017 17:12

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  35. Content type: Research article

    Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The pu...

    Authors: Stefan Haraldsson, Louise Klarskov, Mef Nilbert, Inge Bernstein, Jesper Bonde and Susanne Holck

    Citation: BMC Clinical Pathology 2017 17:11

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  36. Content type: Research article

    The pathophysiology and outcome of meningococcal septic shock is closely associated with the plasma level of N. meningitidis lipopolysaccharides (LPS, endotoxin) and the circulating level of meningococcal DNA. Th...

    Authors: Berit Sletbakk Brusletto, Bernt Christian Hellerud, Else Marit Løberg, Ingeborg Løstegaard Goverud, Åshild Vege, Jens Petter Berg, Petter Brandtzaeg and Reidun Øvstebø

    Citation: BMC Clinical Pathology 2017 17:10

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  37. Content type: Case report

    Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo. The case of a PDTC adjacent to a ...

    Authors: Hironao Yasuoka, Yasushi Nakamura, Mitsuyoshi Hirokawa, Ken-ichi Yoshida, Kana Anno, Masayuki Tori and Masahiko Tsujimoto

    Citation: BMC Clinical Pathology 2017 17:9

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  38. Content type: Research article

    As the major subfamily of receptor tyrosine, erythropoietin-producing hepatocellular (Eph) receptor has been related to progression and prognosis in different types of tumors. However, the role and mechanism o...

    Authors: Baongoc Nasri, Mikito Inokuchi, Toshiaki Ishikawa, Hiroyuki Uetake, Yoko Takagi, Sho Otsuki, Kazuyuki Kojima and Tatsuyuki Kawano

    Citation: BMC Clinical Pathology 2017 17:8

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  39. Content type: Research article

    The BD MAX™ Enteric Bacterial Panel (BDM-EBP) is designed and FDA-cleared to detect Salmonella, Shigella, Campylobacter, and Shiga toxin genes stx1/2 from stool samples. However, rectal swabs, which are not FDA-c...

    Authors: Barbara DeBurger, Sarah Hanna, Eleanor A. Powell, Cindi Ventrola and Joel E. Mortensen

    Citation: BMC Clinical Pathology 2017 17:7

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  40. Content type: Technical advance

    The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mit...

    Authors: Paulo Refinetti, Christian Arstad, William G. Thilly, Stephan Morgenthaler and Per Olaf Ekstrøm

    Citation: BMC Clinical Pathology 2017 17:6

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  41. Content type: Case report

    The coexistence of Rosai-Dorfman disease (RDD) with Langerhans cell histiocytosis (LCH) is very rare, as to date only 17 cases have been reported in the english literature. The pathophysiology of this uncommon...

    Authors: Boubacar Efared, Asmae Mazti, Badarou Chaibou, Gabrielle Atsame-Ebang, Ibrahim Sory Sidibé, Layla Tahiri, Fatimazahra Erregad, Nawal Hammas, Abdelmajid El Mrini, Hinde El Fatemi and Laila Chbani

    Citation: BMC Clinical Pathology 2017 17:5

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  42. Content type: Research article

    Urothelial bladder carcinoma (UBC) is one of the most prevalent cancers in men worldwide. Human epidermal growth factor receptor 2 (HER2) expression has been detected in a wide range of urothelial carcinoma. D...

    Authors: Mohamed Reda El Ochi, Mohamed Oukabli, Elarbi Bouaiti, Hafsa Chahdi, Adil Boudhas, Mohamed Allaoui, Ahmed Ameur, Mohamed Abbar and Abderrahmane Al Bouzidi

    Citation: BMC Clinical Pathology 2017 17:3

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  43. Content type: Research article

    Detection of vascular invasion by hematoxylin and eosin staining is the current pathological assessment practice to diagnose breast carcinoma. However, conventional hematoxylin and eosin staining failed to dis...

    Authors: Nur Fatiha Norhisham, Choi Yen Chong and Sabreena Safuan

    Citation: BMC Clinical Pathology 2017 17:2

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  44. Content type: Case report

    Mycetoma is a chronic granulomatous infectious disease caused by filamentous bacteria or by fungi. The disease is endemic in certain tropical and subtropical areas of the world but can be found elsewhere posin...

    Authors: Boubacar Efared, Layla Tahiri, Marou Soumana Boubacar, Gabrielle Atsam-Ebang, Nawal Hammas, El Fatemi Hinde and Laila Chbani

    Citation: BMC Clinical Pathology 2017 17:1

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  45. Content type: Research article

    Advanced genomic techniques such as Next-Generation-Sequencing (NGS) and gene expression profiling, including NanoString, are vital for the development of personalised medicines, as they enable molecular disea...

    Authors: Caroline Seiler, Alan Sharpe, J. Carl Barrett, Elizabeth A. Harrington, Emma V. Jones and Gayle B. Marshall

    Citation: BMC Clinical Pathology 2016 16:17

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  46. Content type: Case report

    The recent study described a better outcome in acute promyelocytic leukemia patients treated with all-trans retinoic acid and arsenic oxide compared to those treated with all-trans retinoic acid combined with ...

    Authors: Osamu Imataki and Makiko Uemura

    Citation: BMC Clinical Pathology 2016 16:16

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