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BMC Clinical Pathology


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  1. Content type: Research article

    Advanced genomic techniques such as Next-Generation-Sequencing (NGS) and gene expression profiling, including NanoString, are vital for the development of personalised medicines, as they enable molecular disea...

    Authors: Caroline Seiler, Alan Sharpe, J. Carl Barrett, Elizabeth A. Harrington, Emma V. Jones and Gayle B. Marshall

    Citation: BMC Clinical Pathology 2016 16:17

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  2. Content type: Case report

    The recent study described a better outcome in acute promyelocytic leukemia patients treated with all-trans retinoic acid and arsenic oxide compared to those treated with all-trans retinoic acid combined with ...

    Authors: Osamu Imataki and Makiko Uemura

    Citation: BMC Clinical Pathology 2016 16:16

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  3. Content type: Research article

    Sickle cell disease (SCD) is a class of hemoglobinopathy resulting from a single mutation in the ß-globin chain inducing the substitution of valine for glutamic acid at the sixth amino acid position which lead...

    Authors: Vicky Jocelyne Ama Moor, Constant Anatole Pieme, Bernard Chetcha Chemegne, Helene Manonji, Borgia Legrand Njinkio Nono, Corine Tchoula Mamiafo, Bruno Moukette Moukette, Francine Tankeu Nzufo and Asonganyi Tazoacha

    Citation: BMC Clinical Pathology 2016 16:15

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  4. Content type: Research article

    Omega-3 long chain-polyunsaturated fatty acids (LC-PUFAs)–docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and eicosapentaenoic acid (EPA)– and omega-6 LC-PUFA arachidonic acid (ARA), are essential for ...

    Authors: Grace Mashavave, Patience Kuona, Willard Tinago, Babill Stray-Pedersen, Marshall Munjoma and Cuthbert Musarurwa

    Citation: BMC Clinical Pathology 2016 16:14

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  5. Content type: Research article

    Calcifications of atherosclerotic plaques represent a controversial issue as they either lead to the stabilization or rupture of the lesion. However, the cellular key players involved in the progression of the...

    Authors: Silvia Fittipaldi, Francesco Vasuri, Alessio Degiovanni, Rodolfo Pini, Mauro Gargiulo, Andrea Stella, Gianandrea Pasquinelli, William G. Thilly and Elena V. Gostjeva

    Citation: BMC Clinical Pathology 2016 16:12

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  6. Content type: Research article

    Podocalyxin-like protein (PODXL) is a cell surface transmembrane glycoprotein, the expression of which has been associated with poor prognosis in a range of malignancies. The aim of this study was to investiga...

    Authors: David Borg, Charlotta Hedner, Björn Nodin, Anna Larsson, Anders Johnsson, Jakob Eberhard and Karin Jirström

    Citation: BMC Clinical Pathology 2016 16:13

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  7. Content type: Research article

    Effective management of trauma-related invasive fungal wound infections (IFIs) depends on early diagnosis and timely initiation of treatment. We evaluated the utility of routine staining, histochemical stains ...

    Authors: Sarah M. Heaton, Amy C. Weintrob, Kevin Downing, Bryan Keenan, Deepak Aggarwal, Faraz Shaikh, David R. Tribble and Justin Wells

    Citation: BMC Clinical Pathology 2016 16:11

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  8. Content type: Research article

    Repeat cytology and HPV testing is used in triage of women with minor cytological lesions. The objective of this study was to evaluate 14-type HPV DNA and 5-type HPV mRNA testing in delayed triage of women wit...

    Authors: Bjørn Westre, Anita Giske, Hilde Guttormsen, Sveinung Wergeland Sørbye and Finn Egil Skjeldestad

    Citation: BMC Clinical Pathology 2016 16:9

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  9. Content type: Case report

    Cellular angiofibroma represents a newly described, site specific tumor. Histologically, CAF is a benign mesenchymal neoplasm characterized by two principal components: bland spindle cells and prominent small ...

    Authors: Mouna Khmou, Najat Lamalmi, Abderrahmane Malihy, Lamia Rouas and Zaitouna Alhamany

    Citation: BMC Clinical Pathology 2016 16:8

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  10. Content type: Case report

    In the spectrum of molecular alterations found in hepatocellular carcinoma (HCC), somatic mutations in the WNT/β-catenin pathway and the p53/cell cycle control pathway are among the most frequent ones. It has ...

    Authors: Juliane Friemel, Markus Rechsteiner, Marion Bawohl, Lukas Frick, Beat Müllhaupt, Mickaël Lesurtel and Achim Weber

    Citation: BMC Clinical Pathology 2016 16:7

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  11. Content type: Case report

    Primary thyroid lymphoma is an uncommon pathological entity that accounts for only 1 to 5 % of all thyroid malignancies. Primary Burkitt lymphoma of the thyroid gland is very rare. This article presents the fi...

    Authors: Mohamed Allaoui, Ilias Benchafai, El Mehdi Mahtat, Safae Regragui, Adil Boudhas, Mustapha Azzakhmam, Mohammed Boukhechba, Abderrahmane Al Bouzidi and Mohamed Oukabli

    Citation: BMC Clinical Pathology 2016 16:6

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  12. Content type: Case report

    Teratomas are a germ cell tumors composed of two or more tissues which originate from ectoderm, endoderm or mesoderm. These tumors commonly arise from the ovary although other extragonadal sites can be involve...

    Authors: Emmanuel Kamgobe, Anthony Massinde, Dismas Matovelo, Edgar Ndaboine, Peter Rambau and Tito Chaula

    Citation: BMC Clinical Pathology 2016 16:5

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  13. Content type: Case report

    Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. They are malignant in 20 % of cases. Only a few cases of malignant phyllodes tumors metastatic to bone hav...

    Authors: Mohamed Reda El Ochi, Mehdi Toreis, Mohamed Benchekroun, Zineb Benkerroum, Mohamed Allaoui, Mohamed Ichou, Basma El Khannoussi, Abderrahman Albouzidi and Mohamed Oukabli

    Citation: BMC Clinical Pathology 2016 16:4

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  14. Content type: Research article

    Adverse local tissue reaction (ALTR), characterized by a heterogeneous cellular inflammatory infiltrate and the presence of corrosion products in the periprosthetic soft tissues, has been recognized as a mecha...

    Authors: Benjamin F. Ricciardi, Allina A. Nocon, Seth A. Jerabek, Gabrielle Wilner, Elianna Kaplowitz, Steven R. Goldring, P. Edward Purdue and Giorgio Perino

    Citation: BMC Clinical Pathology 2016 16:3

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  15. Content type: Research article

    Stillbirth is frequently the result of pathological processes involving the placenta. Understanding the significance of specific lesions is hindered by qualitative subjective evaluation. We hypothesised that q...

    Authors: Imogen Ptacek, Anna Smith, Ainslie Garrod, Sian Bullough, Nicola Bradley, Gauri Batra, Colin P. Sibley, Rebecca L. Jones, Paul Brownbill and Alexander E. P. Heazell

    Citation: BMC Clinical Pathology 2016 16:1

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  16. Content type: Case report

    Leiomyosarcoma is a rare malignant mesenchymal tumor that represents 5–7 % of all soft tissue sarcomas. The occurrence of this tumor in the salivary glands is exceptional. Only five cases are reported in the s...

    Authors: Mohamed Reda El Ochi, Hafsa Chahdi, Issam Rharrassi, Abderrahman Albouzidi and Mohamed Oukabli

    Citation: BMC Clinical Pathology 2015 15:22

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  17. Content type: Research article

    The role of vitamin E in breast cancer prevention and treatment has been widely investigated, and the different tocopherols that comprise this nutrient have been shown to have divergent associations with cance...

    Authors: Xi Wang, Brian Z. Ring, Robert S. Seitz, Douglas T. Ross, Kirsten Woolf, Rodney A. Beck, David G. Hicks and Shuyuan Yeh

    Citation: BMC Clinical Pathology 2015 15:21

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  18. Content type: Research article

    Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, PIK3CA, is one of the most frequently mutated genes in breast cancer, and the mutation status of PIK3CA has clinical relevance related to r...

    Authors: Ruza Arsenic, Denise Treue, Annika Lehmann, Michael Hummel, Manfred Dietel, Carsten Denkert and Jan Budczies

    Citation: BMC Clinical Pathology 2015 15:20

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  19. Content type: Research article

    Lung cancer is one of the most common malignant neoplasms worldwide and has a high mortality rate. To enable individualized therapy regimens, a better understanding of the molecular tumor biology has still to ...

    Authors: Michael Majores, Anne Schindler, Angela Fuchs, Johannes Stein, Lukas Heukamp, Peter Altevogt and Glen Kristiansen

    Citation: BMC Clinical Pathology 2015 15:19

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  20. Content type: Research article

    The “stem cell theory of cancer” states that a subpopulation of cells with stem cell-like properties plays a central role in the formation, sustainment, spread, and drug resistant characteristics of malignant ...

    Authors: Clarissa N. Amaya and Brad A. Bryan

    Citation: BMC Clinical Pathology 2015 15:18

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  21. Content type: Research article

    Previously, we have used clinical and gene expression data from The Cancer Genome Atlas (TCGA) to model a pathway-based index predicting outcomes in ovarian carcinoma. This data were obtained from snap-frozen ...

    Authors: William H. Bradley, Kevin Eng, Min Le, A. Craig Mackinnon, Christina Kendziorski and Janet S. Rader

    Citation: BMC Clinical Pathology 2015 15:17

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  22. Content type: Research article

    Cervical cancer is the leading cause of cancer related death among women in developing countries. Cervical cancer is preceded by cervical surface epithelial cell abnormalities (ECA) which can be detected by Pa...

    Authors: Melkamu Getinet, Baye Gelaw, Abinet Sisay, Eiman A. Mahmoud and Abate Assefa

    Citation: BMC Clinical Pathology 2015 15:16

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  23. Content type: Case report

    The spontaneous rupture of hepatic metastases is rare compared to that of primary hepatic tumors. In addition, vemurafenib, a selective inhibitor of the mutant BRAF protein or gene product, has been reported t...

    Authors: Takuto Nosaka, Katsushi Hiramatsu, Tomoyuki Nemoto, Yasushi Saito, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Hiroyuki Suto, Yoshiaki Imamura and Yasunari Nakamoto

    Citation: BMC Clinical Pathology 2015 15:15

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