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Table 2 Association of percentage of p53 overexpression with various clinical & pathological parameters

From: Prognostic significance of p16 & p53 immunohistochemical expression in triple negative breast cancer

  n (%) P-Value
≤10% (n = 60) 11–50% (n = 18) 51–70% (n = 18) > 70% (n = 54) Total (n = 150)
Age groups
  ≤ 30 years 2(3.3) 0(0) 0(0) 3(5.6) 5(3.3) 0.217
 31–50 years 34(56.7) 7(38.9) 8(44.4) 35(64.8) 84(56)
  > 50 years 24(40) 11(61.1) 10(55.6) 16(29.6) 61(40.7)
Tumor stage/tumor size
 T1(≤2 cm) 3(5) 6(33.3) 3(16.7) 14(25.9) 26(17.3) 0.020
 T2(2.1–5.0 cm) 36(60) 6(33.3) 10(55.6) 27(50) 79(52.7)
 T3(> 5.0 cm) 21(35) 6(33.3) 5(27.8) 13(24.1) 45(30)
ki67 index groups
  ≤ 15% 6(10) 6(33.3) 4(22.2) 1(1.9) 17(11.3) 0.000
 16–24% 2(3.3) 2(11.1) 3(16.7) 1(1.9) 8(5.3)
 25–44% 19(31.7) 6(33.3) 7(38.9) 13(24.1) 45(30)
  > 44% 33(55) 4(22.2) 4(22.2) 39(72.2) 80(53.3)
Nodal Status
 Positive 30(50) 5(27.8) 10(55.6) 19(35.2) 64(42.7) 0.144
 Negative 30(50) 13(72.2) 8(44.4) 35(64.8) 86(57.3)
Nodal Stage
 No 32(53.3) 13(72.2) 8(44.4) 35(64.8) 88(58.7) 0.022
 N1 15(25) 3(16.7) 2(11.1) 10(18.5) 30(20)
 N2 3(5) 1(5.6) 7(38.9) 2(3.7) 13(8.7)
 N3 10(16.7) 1(5.6) 1(5.6) 7(13) 19(12.7)
Histological Subtypes
 IDC 51(85) 14(77.8) 12(66.7) 50(92.6) 127(84.7) 0.063
 Papillary 1(1.7) 2(11.1) 2(11.1) 1(1.9) 6(4)
 Medullary 0(0) 0(0) 1(5.6) 0(0) 1(0.7)
 metaplastic 7(11.7) 2(11.1) 3(16.7) 2(3.7) 14(9.3)
 Mixed 1(1.7) 0(0) 0(0) 1(1.9) 2(1.3)
Tumor Grade
 Grade-I 1(1.7) 0(0) 0(0) 0(0) 1(0.7) 0.118
 Grade-II 6(10) 6(33.3) 1(5.6) 6(11.1) 19(12.7)
 Grade-III 53(88.3) 12(66.7) 17(94.4) 48(88.9) 130(86.7)
Lymhovascular Invasion
 Present 13(21.7) 6(33.3) 7(38.9) 10(18.5) 36(24) 0.250
 Absent 47(78.3) 12(66.7) 11(61.1) 44(81.5) 114(76)
Perinodal extension
 Present 12(20) 2(11.1) 6(33.3) 10(18.5) 30(20) 0.436
 Absent 48(80) 16(88.9) 12(66.7) 44(81.5) 120(80)
Triple Negative phenotype
 Basal 6(10) 2(11.1) 2(11.1) 6(11.1) 16(10.7) 1.000
 Non Basal 54(90) 16(88.9) 16(88.9) 48(88.9) 134(89.3)
  1. Chi-Square test applied
  2. P-value≤0.05 considered as significant
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