Table 2 Association of percentage of p53 overexpression with various clinical & pathological parameters
From: Prognostic significance of p16 & p53 immunohistochemical expression in triple negative breast cancer
n (%) | P-Value | |||||
|---|---|---|---|---|---|---|
≤10% (n = 60) | 11–50% (n = 18) | 51–70% (n = 18) | > 70% (n = 54) | Total (n = 150) | ||
Age groups | ||||||
≤ 30 years | 2(3.3) | 0(0) | 0(0) | 3(5.6) | 5(3.3) | 0.217 |
31–50 years | 34(56.7) | 7(38.9) | 8(44.4) | 35(64.8) | 84(56) | |
> 50 years | 24(40) | 11(61.1) | 10(55.6) | 16(29.6) | 61(40.7) | |
Tumor stage/tumor size | ||||||
T1(≤2 cm) | 3(5) | 6(33.3) | 3(16.7) | 14(25.9) | 26(17.3) | 0.020 |
T2(2.1–5.0 cm) | 36(60) | 6(33.3) | 10(55.6) | 27(50) | 79(52.7) | |
T3(> 5.0 cm) | 21(35) | 6(33.3) | 5(27.8) | 13(24.1) | 45(30) | |
ki67 index groups | ||||||
≤ 15% | 6(10) | 6(33.3) | 4(22.2) | 1(1.9) | 17(11.3) | 0.000 |
16–24% | 2(3.3) | 2(11.1) | 3(16.7) | 1(1.9) | 8(5.3) | |
25–44% | 19(31.7) | 6(33.3) | 7(38.9) | 13(24.1) | 45(30) | |
> 44% | 33(55) | 4(22.2) | 4(22.2) | 39(72.2) | 80(53.3) | |
Nodal Status | ||||||
Positive | 30(50) | 5(27.8) | 10(55.6) | 19(35.2) | 64(42.7) | 0.144 |
Negative | 30(50) | 13(72.2) | 8(44.4) | 35(64.8) | 86(57.3) | |
Nodal Stage | ||||||
No | 32(53.3) | 13(72.2) | 8(44.4) | 35(64.8) | 88(58.7) | 0.022 |
N1 | 15(25) | 3(16.7) | 2(11.1) | 10(18.5) | 30(20) | |
N2 | 3(5) | 1(5.6) | 7(38.9) | 2(3.7) | 13(8.7) | |
N3 | 10(16.7) | 1(5.6) | 1(5.6) | 7(13) | 19(12.7) | |
Histological Subtypes | ||||||
IDC | 51(85) | 14(77.8) | 12(66.7) | 50(92.6) | 127(84.7) | 0.063 |
Papillary | 1(1.7) | 2(11.1) | 2(11.1) | 1(1.9) | 6(4) | |
Medullary | 0(0) | 0(0) | 1(5.6) | 0(0) | 1(0.7) | |
metaplastic | 7(11.7) | 2(11.1) | 3(16.7) | 2(3.7) | 14(9.3) | |
Mixed | 1(1.7) | 0(0) | 0(0) | 1(1.9) | 2(1.3) | |
Tumor Grade | ||||||
Grade-I | 1(1.7) | 0(0) | 0(0) | 0(0) | 1(0.7) | 0.118 |
Grade-II | 6(10) | 6(33.3) | 1(5.6) | 6(11.1) | 19(12.7) | |
Grade-III | 53(88.3) | 12(66.7) | 17(94.4) | 48(88.9) | 130(86.7) | |
Lymhovascular Invasion | ||||||
Present | 13(21.7) | 6(33.3) | 7(38.9) | 10(18.5) | 36(24) | 0.250 |
Absent | 47(78.3) | 12(66.7) | 11(61.1) | 44(81.5) | 114(76) | |
Perinodal extension | ||||||
Present | 12(20) | 2(11.1) | 6(33.3) | 10(18.5) | 30(20) | 0.436 |
Absent | 48(80) | 16(88.9) | 12(66.7) | 44(81.5) | 120(80) | |
Triple Negative phenotype | ||||||
Basal | 6(10) | 2(11.1) | 2(11.1) | 6(11.1) | 16(10.7) | 1.000 |
Non Basal | 54(90) | 16(88.9) | 16(88.9) | 48(88.9) | 134(89.3) | |