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Table 3 Association of lymphatic vessel invasion with clinical criteria

From: Peritumoral lymphatic vessel density and invasion detected with immunohistochemical marker D240 is strongly associated with distant metastasis in breast carcinoma

   Intra-tumoral LVI Peri-tumoral LVI Total LVI
Positive Negative p-value Positive Negative p-value Positive Negative p-value
Age <40 2 (7.1) 2 (7.1) 1.0 4 (14.8) 0 (0) 0.012 4 (10.5) 0 (0) 0.065
≥40 26 (92.9) 26 (92.9) 23 (85.2) 30 (100) 34 (89.5) 19 (100)
Tumor size <30 7 (25) 4 (14.8) 0.548 4 (14.8) 7 (25) 0.636 9 (23.7) 2 (11.8) 0.497
30 ≤ × < 60 12 (42.9) 15 (55.6) 14 (51.9) 13 (46.4) 17 (44.7) 10 (58.8)
60 ≥ 9 (32.1) 8 (29.6) 9 (33.3) 8 (28.6) 12 (31.6) 5 (29.4)
Grade I 3 (10.7) 7 (25.0) 0.387 5 (18.5) 5 (17.2) 0.197 5 (13.2) 5 (27.8) 0.607
II 14 (50.0) 13 (46.4) 15 (55.6) 12 (41.4) 19 (50) 8 (44.4)
III 10 (35.7) 6 (21.4) 7 (25.9) 9 (31.0) 12 (31.6) 4 (22.2)
No grade 1 (3.33) 2 (7.1) 0 3 (10.3) 2 (5.3) 1 (5.6)
Distant metastasis Yes 9 (32.1) 6 (21.4) 0.432 7 (25.9) 8 (26.7) 0.05 11 (28.9) 4 (21.1 0.607
No 18 (64.3) 19 (67.9) 20 (74.1) 18 (60.0) 25 (65.8) 13 (68.4)
Not determine 1 (3.6) 3 (10.7) 0 4 (13.3) 2 (5.3) 2 (10.5)
Recurrence No 26 (92.9) 28 (100) 0.92 27 (100) 28 (93.3) 0.105 36 (94.7) 19 (100) 0.198
Yes 2 (7.1) 0 0 2 (6.7) 2 (5.3) 0
ER Positive 16 (59.3) 15 (55.6) 0.632 15 (57.7) 17 (58.6) 0.944 21 (56.8) 11 (61.1) 0.738
Negative 11 (40.7) 12 (44.4) 11 (42.3) 2 (41.4) 16 (43.2) 7 (38.9)
PR Positive 13 (46.4) 14 (51.9) 0.687 13 (48.1) 15 (51.7) 0.789 17 (44.7) 11 (61.1) 0.251
Negative 15 (53.6) 13 (48.1) 14 (51.9) 14 (48.3) 21 (55.3) 7 (38.9)
Lymph nodes involvement 0 10 (37.0) 9 (32.1) 0.983 7 (25.9) 12 (41.4) 0.088 13 (35.1) 6 (31.6) 0.763
1 3 (11.1) 3 (10.7) 1 (3.7) 5 (17.2) 3 (8.1) 3 (15.8)
2 to 4 7 (25.9) 8 (28.6) 11 (40.7) 5 (17.2) 10 (27) 6 (31.6)
>4 7 (25.9) 8 (28.6) 8 (29.6) 7 (24.1) 11 (29.7) 4 (21.1)
  1. *Bold datas refer to statistically significant association (p<0.05)
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