Fig. 3

Osteolysis features in the MoM RHA group. a Femoral head with orthopedic cement cap lined by papillary neo-synovium and showing osteolytic cavity involving the central groove of the metallic stem, white arrow (Smith and Nephew Birmingham, implantation time 48 months). b Content of the osteolytic cavity composed of particle laden macrophages with central exfoliation of necrotic forms in the right upper corner (H-E x100) and detail of the cavity lining cell layer containing greenish corrosion products in inset (x400). c Particle laden macrophagic infiltrate under the orthopedic cement cap lined by multinucleated giant cells (H-E x400). d Hematopoietic marrow with particle laden macrophages without evidence of lymphocytic reaction (H-E x400). e Femoral head with orthopedic cement cap lined by papillary neo-synovium with charcoal grey bone marrow, secondary to diffuse permeation by macrophagic infiltrate with metallic wear content (Smith and Nephew Birmingham, implantation time 78 months). f Massive macrophagic infiltrate in bone marrow containing greenish particles of corrosion products and black particles of abrasion metallic wear without evidence of osteoclastic activity (H-E x200). g Seeding of particle-laden macrophages in fatty marrow indicative of increased motility (H-E x100). h Large aggregate of lymphocytes positive for T-cell (CD3) and B-cell (CD20) marker (not shown) with interspersed particle laden macrophages, black arrows (H-E x 400)