Fig. 2

Sequential images of abdominal computed tomography (CT). These images are from September 2012 (a), November 2012 (b), and December 2012 (c). There is a metastatic tumor in the right lobe of the liver (a). Initially, the hepatic metastases considerably respond to vemurafenib treatment, and they become almost invisible (b). Later, they grow rapidly and rupture, resulting in a large amount of free fluid within the peritoneal cavity surrounding the liver (c). The yellow arrow demonstrates the same tumor in each image