Table 1 Selected recommendations of CAP consensus conference XXXVI: Diagnostic Issues in Thrombophilia

Initial testing for factor V Leiden may in most cases be appropriately performed by either direct DNA or functional (i.e. 2^nd generation activated protein C resistance (APC resistance) assays [[9, 10]]

Initial testing for antithrombin deficiency should be via the functional assay, rather than the total antigen assay [6]

Initial testing for protein C deficiency should be via the functional assay, rather than the total antigen assay [7]

Initial testing for protein S deficiency should be via either the functional assay or the free antigen assay, rather than the total antigen assay [8]

It is preferable that testing for antithrombin, protein C or protein S deficiency take place after the patient has recovered from the acute thrombosis. [[6–8]]

It is preferable that testing for antithrombin, protein C or protein S deficiency take place when the patient is not on oral anticoagulant therapy [[6–8]].