Age-related differences in 1p and 19q deletions in oligodendrogliomas

Myal, Yvonne; Del Bigio, Marc R; Rhodes, Roy H

doi:10.1186/1472-6890-3-6

Table 3 Summary of LOH data in 63 gliomas.

			Deletion detected
Group	Age	Sex	Chromosome 1		Chromosome 19		Histological Diagnosis:	WHO Grade
			D1S508	D1S2734	D19S219	D19S412
1	53	F	1 deletion	non-informative	0 deletion	non-informative	oligodendroglioma, anaplastic	3
	34	F	1 deletion	1 deletion	1 deletion	1 deletion	oligodendroglioma, anaplastic	3
	28	F	non-informative	0 deletion	0 deletion	0 deletion	oligodendroglioma, anaplastic	3
	27	M	0 deletion	non-informative	1 deletion	1 deletion	oligodendroglioma, anaplastic	3
*	16	M	0 deletion	0 deletion	0 deletion	non-informative	oligodendroglioma, anaplastic	3
	48	M	non-informative	1 deletion	1 deletion	1 deletion	oligodendroglioma, anaplastic	3
	45	M	0 deletion	0 deletion	1 deletion	1 deletion	oligodendroglioma, anaplastic	3
	41	M	non-informative	1 deletion	1 deletion	1 deletion	oligodendroglioma, anaplastic	3
	30	M	non-informative	1 deletion	1 deletion	non-informative	oligodendroglioma, anaplastic	3
	57	F	non-informative	non-informative	1 deletion	1 deletion	oligodendroglioma	2
	56	M	1 deletion	1 deletion	1 deletion	non-informative	oligodendroglioma	2
	54	F	1 deletion	1 deletion	1 deletion	1 deletion	oligodendroglioma	2
	53	F	1 deletion	1 deletion	1 deletion	1 deletion	oligodendroglioma	2
	52	M	1 deletion	1 deletion	non-informative	1 deletion	oligodendroglioma	2
	49	M	1 deletion	1 deletion	1 deletion	1 deletion	oligodendroglioma	2
	43	F	1 deletion	1 deletion	1 deletion	non-informative	oligodendroglioma	2
	38	F	non-informative	0 deletion	non-informative	0 deletion	oligodendroglioma	2
	37	M	1 deletion	1 deletion	non-informative	1 deletion	oligodendroglioma	2
	37	M	0 deletion	0 deletion	0 deletion	0 deletion	oligodendroglioma	2
	35	M	1 deletion	1 deletion	1 deletion	1 deletion	oligodendroglioma	2
	32	M	non-informative	non-informative	0 deletion	non-informative	oligodendroglioma	2
	28	M	non-informative	0 deletion	non-informative	0 deletion	oligodendroglioma	2
	25	M	1 deletion	non-informative	1 deletion	1 deletion	oligodendroglioma	2
*	17	M	0 deletion	0 deletion	non-informative	0 deletion	oligodendroglioma	2
*	2	F	0 deletion	0 deletion	0 deletion	0 deletion	oligodendroglioma	2
#,+	41	F	1 deletion	0 deletion	1 deletion	0 deletion	oligoastrocytoma, anaplastic	3
	54	M	0 deletion	0 deletion	0 deletion	0 deletion	oligoastrocytoma, anaplastic	3
	37	F	0 deletion	0 deletion	1 deletion	1 deletion	oligoastrocytoma, anaplastic	3
	34	M	0 deletion	0 deletion	0 deletion	0 deletion	oligoastrocytoma, anaplastic	3
	48	M	0 deletion	0 deletion	0 deletion	0 deletion	oligoastrocytoma	2
	48	F	0 deletion	0 deletion	0 deletion	0 deletion	oligoastrocytoma	2
	26	M	1 deletion	non-informative	1 deletion	1 deletion	oligoastrocytoma	2
	59	F	1 deletion	non-informative	0 deletion	0 deletion	glioblastoma multiforme	4
	58	F	0 deletion	0 deletion	1 deletion	1 deletion	glioblastoma multiforme	4
	57	F	non-informative	0 deletion	0 deletion	non-informative	glioblastoma multiforme	4
	53	M	0 deletion	0 deletion	1 deletion	1 deletion	glioblastoma multiforme	4
	46	F	0 deletion	0 deletion	0 deletion	0 deletion	glioblastoma multiforme	4
	31	F	1 deletion	1 deletion	1 deletion	1 deletion	glioblastoma multiforme	4
	29	M	0 deletion	0 deletion	0 deletion	non-informative	glioblastoma multiforme	4
*	8	M	1 deletion	1 deletion	1 deletion	1 deletion	glioblastoma multiforme	4
*	2	M	non-informative	0 deletion	0 deletion	non-informative	glioblastoma multiforme	4
2	62	M	0 deletion	0 deletion	non-informative	1 deletion	oligodendroglioma, anaplastic	3
	70	M	non-informative	0 deletion	0 deletion	non-informative	oligodendroglioma, anaplastic	3
	71	F	non-informative	0 deletion	0 deletion	non-informative	oligodendroglioma, anaplastic	3
	66	M	non-informative	0 deletion	0 deletion	non-informative	oligodendroglioma, anaplastic	3
	74	F	non-informative	non-informative	0 deletion	0 deletion	oligodendroglioma, anaplastic	3
	62	M	0 deletion	0 deletion	0 deletion	non-informative	oligodendroglioma	2
	61	M	0 deletion	0 deletion	non-informative	0 deletion	oligoastrocytoma, anaplastic	3
	78	M	0 deletion	0 deletion	0 deletion	0 deletion	oligoastrocytoma, anaplastic	3
	60	M	non-informative	0 deletion	1 deletion	1 deletion	glioblastoma multiforme	4
	61	M	0 deletion	0 deletion	non-informative	0 deletion	glioblastoma multiforme	4
	64	M	0 deletion	non-informative	0 deletion	0 deletion	glioblastoma multiforme	4
	64	M	0 deletion	0 deletion	0 deletion	0 deletion	glioblastoma multiforme	4
#	65	F	1 deletion	0 deletion	1 deletion	non-informative	glioblastoma multiforme	4
	66	M	1 deletion	1 deletion	1 deletion	1 deletion	glioblastoma multiforme	4
	66	M	non-informative	0 deletion	non-informative	0 deletion	glioblastoma multiforme	4
	70	M	0 deletion	0 deletion	1 deletion	1 deletion	glioblastoma multiforme	4
	74	M	0 deletion	0 deletion	0 deletion	0 deletion	glioblastoma multiforme	4
	74	M	non-informative	0 deletion	non-informative	non-informative	glioblastoma multiforme	4
	75	M	0 deletion	0 deletion	1 deletion	1 deletion	glioblastoma multiforme	4
	76	M	1 deletion	non-informative	0 deletion	0 deletion	glioblastoma multiforme	4
	70	M	0 deletion	0 deletion	0 deletion	0 deletion	dysembryoplastic neuroepithial tumor	1
	73	F	0 deletion	0 deletion	0 deletion	0 deletion	astrocytoma, anaplastic	3

* pediatric patients. # partial deletions on chromosome 1. + anaplastic with post radiation changes. Homozygous: Both parental alleles in the patient's normal constitutional DNA are identical and migrated as 1 apparent band on a polyacrylamide gel. Homozygous alleles were considered non-informative and not used in the analysis. 0 deletion: The parental alleles migrated as 2 separate bands (heterozygous alleles) and no LOH was detected in the tumor DNA. 1 deletion: The tumor DNA demonstrated a LOH at that locus.

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ISSN: 1472-6890

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