BMC Clinical Pathology

Table 3 Angiogenic markers as predictors for disease-specific survival, metastasis and local recurrence in patients with resected visceral & retroperitoneal soft-tissue sarcomas (univariate analyses, log rank test, n = 66)

From: The VEGF- and PDGF-family of angiogenic markers have prognostic impact in soft tissue sarcomas arising in the extremities and trunk

		Disase-specific survival		Metastasis-free survival		Recurrence-free survival
Marker expression	Patients (n)	5-Year survival (%)	P	5-Year survival (%)	P	5-Year survival (%)	P
PDGF-A
Low	23	49	0.473	63	0.593	65	0.315
High	39	63		54		73
Missing	4
PDGF-B
Low	14	54	0.604	82	0.088	61	0.291
High	48	59		51		73
Missing	4
PDGF-C
Low	20	39	0.297	59	0.986	53	0.045
High	41	65		56		76
Missing	5
PDGF-D
Low	48	52	0.078	52	0.197	70	0.343
High	15	80		73		59
Missing	3
PDGFR-α
Low	41	56	0.672	61	0.527	71	0.761
High	21	61		51		66
Missing	4
PDGFR-β
Low	58	57	0.360	54	0.532	70	0.766
High	4	75		75		75
Missing	4
VEGF-A
Low	34	51	0.326	64	0.719	64	0.054
High	29	68		53		79
Missing	3
VEGF-C
Low	34	66	0.402	69	0.071	62	0.051
High	29	50		45		84
Missing	3
VEGF-D
Low	34	60	0.856	62	0.388	63	0.116
High	30	55		51		78
Missing	2
VEGFR-1
Low	37	55	0.724	63	0.358	70	0.510
High	25	63		49		71
Missing	3
VEGFR-2
Low	44	55	0.858	63	0.446	69	0.821
High	19	67		48		75
Missing	3
VEGFR-3
Low	36	54	0.552	59	0.821	65	0.220
High	25	61		52		76
Missing	5
FGF2
Low	39	56	0.805	51	0.214	74	0.748
High	20	65		67		66
Missing	7
FGFR-1
Low	43	45	0.023	56	0.385	68	0.448
High	20	89		63		78
Missing	3

Abbreviations: PDGF Platelet-derived growth factor, PDGFR Platelet-derived growth factor receptor, VEGF Vascular endothelial growth factor, VEGFR Vascular endothelial growth factor receptor, FGF Fibroblast growth factor, FGFR Fibroblast growth factor receptor.

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ISSN: 1472-6890

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