|
Factor
|
HR
|
95% CI
|
P
|
|---|
|
Tumor status
| | |
0.002*
|
|
1
|
1.00
| | |
|
2
|
1.54
|
0.91 – 2.59
|
0.108
|
|
3
|
2.73
|
1.53 – 4.90
|
0.001
|
|
Nodal status
| | |
<0.001*
|
|
0
|
1.00
| | |
|
1
|
1.98
|
1.27 – 3.08
|
0.003
|
|
2
|
3.13
|
1.80 – 5.46
|
<0.001
|
|
Histology
| | | |
|
SCC
|
1.00
| | |
|
Other NSCLC
|
0.99
|
0.500 – 1.98
|
0.986
|
|
Differentiation
| | |
0.094*
|
|
Poor
|
1.00
| | |
|
Moderate
|
0.70
|
0.46 – 1.05
|
0.083
|
|
Well
|
0.56
|
0.29 – 1.10
|
0.095
|
|
Performance status
| | | |
|
ECOG = 0
|
1.00
| | |
|
ECOG = 1-2
|
1.80
|
1.23 – 2.64
|
0.003
|
|
Vascular infiltration
| | | |
|
No
|
1.00
| | |
|
Yes
|
1.82
|
1.12 – 2.98
|
0.016
|
|
Dicer**
|
0.87
|
0.65 – 1.16
|
0.333
|
|
Dicer*Histology***
|
1.27
|
1.00 – 1.61
|
0.049
|
|
Drosha / miR-126
| | |
0.033*
|
|
Low / Low
|
1.00
| | |
|
Low / High
|
1.13
|
0.62 – 2.05
|
0.696
|
|
High / Low
|
0.63
|
0.37 – 1.07
|
0.089
|
|
High / High
|
1.96
|
1.04 – 3.69
|
0.037
|
- *Overall significance as a prognostic factor.
- **B = −0.141.
- ***B = 0.240.
- Dicer*Histology = the interaction between Dicer and Histology.
- HR: Hazard ration; CI: confidence interval.
