Figure 3
From: Challenging dedifferentiated liposarcoma identified by MDM2-amplification, a report of two cases
Molecular hallmarks of Case #1: Immunohistochemistry demonstrates co-overexpression of CDK4 (B) and MDM2 (C) in both the poorly and higher differentiated areas (A: HE-staining of corresponding region). Fluorescence in situ hybridisation shows strong amplification of the MDM2 locus as underlying genetic alteration (D; Green: MDM2 probe, Red: Chromosome 12 reference probe). The features are characteristic of dedifferentiated liposarcoma.