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Table 3 Panels of biomarkers used for analysis of specificity and sensitivity, using 10% positive cells and 20% positive cells as cut-off thresholds for positivity

From: Expression of KOC, S100P, mesothelin and MUC1 in pancreatico-biliary adenocarcinomas: development and utility of a potential diagnostic immunohistochemistry panel

10% positive cells as cut-off

Panels

Sensitivity

Specificity

KOC, S100P, Mesothelin, MUC1

100%

40%

KOC , S100P , Mesothelin

100%

88%

KOC , Mesothelin

97%

87%

KOC, S100P

98%

96%

KOC, S100P , Mesothelin *

100%

99%

20 % positive cells as cut - off

Panels

Sensitivity

Specificity

KOC , S100P , Mesothelin , MUC1

100%

65%

KOC , S100P , Mesothelin

99%

94%

KOC , Mesothelin

96%

93%

KOC , S100P

99%

99%

KOC , S100P , Mesothelin *

100%

100%

  1. Note: *At least 2 biomarkers required to be positive in this panel. In the rest of the panels only one biomarker was required to be positive in a panel.