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Table 3 Panels of biomarkers used for analysis of specificity and sensitivity, using 10% positive cells and 20% positive cells as cut-off thresholds for positivity

From: Expression of KOC, S100P, mesothelin and MUC1 in pancreatico-biliary adenocarcinomas: development and utility of a potential diagnostic immunohistochemistry panel

10% positive cells as cut-off
Panels Sensitivity Specificity
KOC, S100P, Mesothelin, MUC1 100% 40%
KOC , S100P , Mesothelin 100% 88%
KOC , Mesothelin 97% 87%
KOC, S100P 98% 96%
KOC, S100P , Mesothelin * 100% 99%
20 % positive cells as cut - off
Panels Sensitivity Specificity
KOC , S100P , Mesothelin , MUC1 100% 65%
KOC , S100P , Mesothelin 99% 94%
KOC , Mesothelin 96% 93%
KOC , S100P 99% 99%
KOC , S100P , Mesothelin * 100% 100%
  1. Note: *At least 2 biomarkers required to be positive in this panel. In the rest of the panels only one biomarker was required to be positive in a panel.