Table 3 Topmost five upstream regulators predicted for the 55 Upr I/U-DEGs unique to P.a. -infected wounds on POD6 in the categories Cytokine, G-protein-coupled receptor, Growth factor, Ligand-dependent nuclear receptor, and Transmembrane receptor
Upstream regulator | Log ratio | Activation z-score | p-value of overlap | Target molecules in dataset |
|---|---|---|---|---|
TLR3 | 0.340 | 3.111 | 7.13E-19 | CXCL10, DDX58, DHX58, GBP4, GCH1, IFIH1, IFIT1, IFIT3, IL15, IL23A, IRF7, STAT1, TLR3, TNFSF10, USP18, ZNFX1 |
IFN Beta | 3.395 | 1.34E-16 | CXCL10, IFIH1, IFIT1, IFIT1B, IL15, IRF7, STAT1, TAPBP, TLR3, TNFSF10, USP18, XAF1 | |
Interferon alpha | 3.913 | 1.67E-16 | CXCL10, DDX58, DHX58, IFIH1, IFIT1, IFIT1B, IFIT3, IL15, IRF7, PRF1, STAT1, TAPBP, TLR3, TNFSF10, USP18, WARS | |
IFN type 1 | 2.087 | 3.44E-15 | CXCL10, DDX58, DHX58, IFIH1, IFIT1, IFIT1B, STAT1, TNFSF10, UBA7 | |
Ifn | 2.793 | 4.54E-12 | CXCL10, DDX58, DHX58, IFIH1, IFIT1, IL15, IRF7, STAT1, TLR3 |