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Table 2 Immunohistochemistry results

From: Women with familial risk for breast cancer have an increased frequency of aldehyde dehydrogenase expressing cells in breast ductules

Patients Median percentage of TDLUs containing ALDH+ cells (range)
Luminal ductular level Intermediate ductular level Basal ductular level
Pre-menopausal with family history of breast cancer, including patients with BRCA1 or BRCA2 mutation (n = 37) 12 (0–62)** 12 (0–53)** 2 (0–18)
Pre-menopausal with BRCA1 mutation (n = 18) 15 (2–50)* 15 (6–38)* 4 (0–18)
Pre-menopausal with BRCA2 mutation (n = 13) 14 (0–62)* 8 (2–53)* 0 (0–18)
Pre-menopausal without family history of breast cancer (n = 25) 6 (0–29) 6 (0–44) 0 (0–29)
Post-menopausal receiving HRT at the time of surgery (n = 7) 10 (0–38)* 8 (0–38)* 2 (0–21)
Post-menopausal not receiving HRT at the time of surgery (n = 24) 4 (0–32) 4 (0–34) 0 (0–18)
Nocancer, underwent mammoplasty (n = 34) 6 (0–32) 4 (0–44) 0 (0–29)
  1. A statistical comparison of ALDH immunohistochemistry results for patients with and without a family history of breast cancer, and patients who were or were not receiving HRT at the time of surgery.
  2. *P ≤ 0.05.
  3. **P ≤ 0.01.
  4. ALDH, aldehyde dehydrogenase 1 A1; TDLU, terminal duct lobular unit; HRT, hormone replacement therapy.