Table 2 Analysis of the expression of genes according to the categorization of covariates with descriptions of the fold regulation and statistical differences (Mann–Whitney U test; p values are shown in parentheses) in the study cohort (n = 114)
Covariates | Comparison performed | Genes | ||||
|---|---|---|---|---|---|---|
Control vs. test group | ITGA3 | ITGA5 | ITGA6 | ITGB5 | ITGAV | |
FR ( p ) | FR ( p ) | FR ( p ) | FR ( p ) | FR ( p ) | ||
Gender | Female vs. male | - 1.81 (0.377) | 1.20 (0.467) | 1.22 (0.599) | 1.04 (0.360) | 1.17 (0.068) |
Age | <60 vs. ≥60 years | 1.27 (0.301) | -1.54 (0.016) | 1.15 (0.524) | 1.14 (0.267) | -1.22 (0.128) |
Histological classification | Adeno. vs. mucinous | 4.02 (0.700) | 1.25 (0.029) | -1.05 (0.358) | 1.34 (0.815) | -1.02 (0.983) |
Tumor grading | Low vs. high grade | 2.94 (0.752) | 1.88 (0.05) | -1.34 (0.098) | 1.36 (0.889) | 1.08 (0.371) |
Venous invasion | Absent vs. present | 1.78 (0.653) | -1.13 (0.510) | 1.42 (0.047) | 1.12 (0.718) | 1.02 (0.818) |
Lymphatic vessel invasion | Absent vs. present | 1.18 (0.619) | -1.47 (0.119) | 1.10 (0.878) | -1.03 (0.643) | -1.03 (0.914) |
Perineural invasion | Absent vs. present | -4.11 (0.782) | 1.00 (0.971) | 1.36 (0.544) | -1.74 (0.686) | 1.37 (0.028) |
Clinical stage (TNM) | I vs. III | 2.40 (0.025) | 1.08 (0.642) | - 1.47 (0.869) | 1.30 (0.042) | 1.14 (0.348) |