Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas

BMC Clinical Pathology

Table 1 Prognostic clinicopathological variables as predictors for disease-specific survival soft tissue sarcomas (univariate analysis, log rank test), N = 249

Characteristic		Patients (n)	Patients (%)	Median survival (months)	5-Year survival (%)	P
Age
≤ 20 years		20	8	15	40	0.126
21-60 years		113	45	68	52
> 60 years		116	47	30	40
Gender
Male		110	44	41	46	0.390
Female		139	56	45	45
Nationality
Norwegian		167	67	63	51	0.011
Russian		82	33	22	34
Histology
Undifferentiated pleomorphic sarcoma		68	27	29	40	0.102
Leiomyosarcoma		67	27	45	46
Liposarcoma		34	14	NR	67
MF/MFT		20	8	43	50
Angiosarcoma		13	5	10	31
Rhabdomyosarcoma		16	6	17	38
MPNST		11	4	49	45
Synovial sarcoma		16	6	31	29
Other STS		4	2	NR	75
Tumor localization
Extremities		89	36	100	53	0.348
Trunk		47	29	32	44
Retroperitoneum		37	25	25	38
Head/Neck		18	7	15	41
Visceral		58	23	30	42
Tumor size
< 5 cm		74	30	127	57	0.027
5-10 cm		91	37	44	45
> 10 cm		81	32	28	37
Missing		3	1
Malignancy grade FNCLCC
1		61	25	NR	74	<0.001
2		98	39	41	45
3		90	36	16	26
Tumor depth
Superficial		17	7	NR	93	<0.001
Deep		232	93	36	42
Metastasis at time of diagnosis
No	206		83	76	53	<0.001
Yes	43		17	10	10
Surgery
Yes	228		92	59	50	<0.001
No	21		8	5	0
Surgical margins
Wide	108		43	NR	62	<0.001
Non-wide	141		57	19	33
Chemotherapy
No	191		77	52	47	0.424
Yes	58		23	29	40
Radiotherapy
No	176		71	48	46	0.590
Yes	73		29	38	43

Abbreviations: MF/MFT, malignant fibroblastic/myofibroblastic tumors; MPNST, malignant peripheral nerve sheath tumor; STS, soft tissue sarcomas; NR, not reached; NOS, non specified.

ISSN: 1472-6890