Dual color chromogenic in situ hybridization for determination of HER2 status in breast cancer: a large comparative study to current state of the art fluorescence in situ hybridization

Table 6 Mean HER2/CEN-17 ratio and signal numbers for all specimens with a HER2/CEN-17 CISH ratio below 3.

Signal copy numbers were normalized to 20 nuclei
a) Not significantly different from CISH ratio in a two tailed, paired t-test (N = 316, P = 0.326)
b) Not significantly different from CISH ratio in a two tailed, paired t-test (N = 318, P = 0.982)
c) Significantly different from CISH HER2 signals in a two tailed, paired t-test (N = 316, P < 0.001)
d) Significantly different from CISH HER2 signals in a two-tailed, paired t-test (N = 318, P < 0.001)
e) Significantly different from CISH CEN-17 signals in a two tailed, paired t-test (N = 316, P < 0.001)
f) Significantly different from CISH CEN-17 signals in a two-tailed, paired t-test (N = 318, P < 0.001)

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