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  1. Research article

    Prevalence and predictors of Pap smear cervical epithelial cell abnormality among HIV-positive and negative women attending gynecological examination in cervical cancer screening center at Debre Markos referral hospital, East Gojjam, Northwest Ethiopia

    Cervical cancer is the leading cause of cancer related death among women in developing countries. Cervical cancer is preceded by cervical surface epithelial cell abnormalities (ECA) which can be detected by Pa...

    Melkamu Getinet, Baye Gelaw, Abinet Sisay, Eiman A. Mahmoud and Abate Assefa

    BMC Clinical Pathology 2015 15:16

    Published on: 23 September 2015

  2. Case report

    Ruptured hepatic metastases of cutaneous melanoma during treatment with vemurafenib: an autopsy case report

    The spontaneous rupture of hepatic metastases is rare compared to that of primary hepatic tumors. In addition, vemurafenib, a selective inhibitor of the mutant BRAF protein or gene product, has been reported t...

    Takuto Nosaka, Katsushi Hiramatsu, Tomoyuki Nemoto, Yasushi Saito, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Hiroyuki Suto, Yoshiaki Imamura and Yasunari Nakamoto

    BMC Clinical Pathology 2015 15:15

    Published on: 3 September 2015

  3. Research article

    A retrospective analysis of breast cancer subtype based on ER/PR and HER2 status in Ghanaian patients at the Korle Bu Teaching Hospital, Ghana

    Breast cancer is a heterogeneous disease composed of multiple subgroups with different molecular alterations, cellular composition, clinical behaviour, and response to treatment. This study evaluates the occur...

    Bernard Seshie, Nii Armah Adu-Aryee, Florence Dedey, Benedict Calys-Tagoe and Joe-Nat Clegg-Lamptey

    BMC Clinical Pathology 2015 15:14

    Published on: 9 July 2015

  4. Research article

    Histological findings in infants with Gastrointestinal food allergy are associated with specific gastrointestinal symptoms; retrospective review from a tertiary centre

    Gastrointestinal food allergy (GIFA) occurs in 2 to 4 % of children, the majority of whom are infants (<1 year of age). Although endoscopy is considered the gold standard for diagnosing GIFA, it is invasive an...

    Neil Shah, Ru-Xin Melanie Foong, Osvaldo Borrelli, Eleni Volonaki, Robert Dziubak, Rosan Meyer, Mamoun Elawad and Neil J. Sebire

    BMC Clinical Pathology 2015 15:12

    Published on: 16 June 2015

  5. Research article

    Impact of add-on laboratory testing at an academic medical center: a five year retrospective study

    Clinical laboratories frequently receive orders to perform additional tests on existing specimens (‘add-ons’). Previous studies have examined add-on ordering patterns over short periods of time. The objective ...

    Louis S. Nelson, Scott R. Davis, Robert M. Humble, Jeff Kulhavy, Dean R. Aman and Matthew D. Krasowski

    BMC Clinical Pathology 2015 15:11

    Published on: 7 June 2015

  6. Research article

    Prognostic and predictive significance of podocalyxin-like protein expression in pancreatic and periampullary adenocarcinoma

    Adenocarcinoma of the periampullary region is associated with poor prognosis and new prognostic and treatment predictive biomarkers are needed for improved treatment. Membranous expression of podocalyxin-like ...

    Margareta Heby, Jakob Elebro, Björn Nodin, Karin Jirström and Jakob Eberhard

    BMC Clinical Pathology 2015 15:10

    Published on: 30 May 2015

  7. Research article

    Tumor-specific expression of HMG-CoA reductase in a population-based cohort of breast cancer patients

    The mevalonate pathway synthetizes cholesterol, steroid hormones, and non-steriod isoprenoids necessary for cell survival. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is the rate-limiting enzyme of...

    Emma Gustbée, Helga Tryggvadottir, Andrea Markkula, Maria Simonsson, Björn Nodin, Karin Jirström, Carsten Rose, Christian Ingvar, Signe Borgquist and Helena Jernström

    BMC Clinical Pathology 2015 15:8

    Published on: 20 May 2015

  8. Technical advance

    A reliable method for the detection of BRCA1 and BRCA2 mutations in fixed tumour tissue utilising multiplex PCR-based targeted next generation sequencing

    Germline mutations in BRCA1 or BRCA2 lead to a high lifetime probability of developing ovarian or breast cancer. These genes can also be involved in the development of non-hereditary tumours as somatic BRCA1/2 pa...

    Gillian Ellison, Shuwen Huang, Hedley Carr, Andrew Wallace, Miika Ahdesmaki, Sanjeev Bhaskar and John Mills

    BMC Clinical Pathology 2015 15:5

    Published on: 24 March 2015

  9. Research article

    Length of prostate biopsies is not necessarily compromised by pooling multiple cores in one paraffin block: an observational study

    Individually submitted prostatic needle biopsies are recommended by most guidelines because of their potential advantage in terms of core quality. However, unspecified bilateral biopsies are commonly submitted...

    Teemu T Tolonen, Jorma Isola, Antti Kaipia, Jarno Riikonen, Laura Koivusalo, Sanna Huovinen, Marita Laurila, Sinikka Porre, Mika Tirkkonen and Paula Kujala

    BMC Clinical Pathology 2015 15:4

    Published on: 8 March 2015

  10. Research article

    SOD2 immunoexpression predicts lymph node metastasis in penile cancer

    Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme in lung, gastric, col...

    Lara Termini, José H Fregnani, Enrique Boccardo, Walter H da Costa, Adhemar Longatto-Filho, Maria A Andreoli, Maria C Costa, Ademar Lopes, Isabela W da Cunha, Fernando A Soares, Luisa L Villa and Gustavo C Guimarães

    BMC Clinical Pathology 2015 15:3

    Published on: 3 March 2015

  11. Case report

    Primary gastric actinomycosis: report of a case diagnosed in a gastroscopic biopsy

    Primary gastric actinomycosis is extremely rare, the appendix and ileocecal region being the most commonly involved sites in abdominopelvic actinomycosis. Herein, we report a case of primary gastric actinomyco...

    Khaleel Al-Obaidy, Fatimah Alruwaii, Areej Al Nemer, Raed Alsulaiman, Zainab Alruwaii and Mohamed A Shawarby

    BMC Clinical Pathology 2015 15:2

    Published on: 26 February 2015

  12. Research article

    Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival

    Dicer and Drosha are important enzymes for processing microRNAs. Recent studies have exhibited possible links between expression of different miRNAs, levels of miRNA processing enzymes, and cancer prognosis. W...

    Kenneth Lønvik, Sveinung W Sørbye, Marit N Nilsen and Ruth H Paulssen

    BMC Clinical Pathology 2014 14:45

    Published on: 11 December 2014

  13. Research article

    Practice of percutaneous needle autopsy; a descriptive study reporting experiences from Uganda

    Percutaneous needle autopsy can overcome a number of barriers that limit the use of complete autopsies. We performed blind-and ultrasound guided needle autopsies in HIV-infected adults in Uganda. In this study...

    Janneke A Cox, Robert L Lukande, Sam Kalungi, Koen Van de Vijver, Eric Van Marck, Ann M Nelson, Asafu Munema, Yukari C Manabe and Robert Colebunders

    BMC Clinical Pathology 2014 14:44

    Published on: 3 December 2014

  14. Research article

    A putative role for homocysteine in the pathophysiology of acute bacterial meningitis in children

    Acute bacterial meningitis frequently causes cortical and hippocampal neuron loss leading to permanent neurological sequelae. Neuron death in acute bacterial meningitis involves the excessive activation of NMD...

    Roney Santos Coimbra, Bruno Frederico Aguilar Calegare, Talitah Michel Sanchez Candiani and Vânia D’Almeida

    BMC Clinical Pathology 2014 14:43

    Published on: 22 November 2014

  15. Research article

    Estrogen receptor alpha and androgen receptor are commonly expressed in well-differentiated liposarcoma

    Liposarcoma (LS) is the second-most common type of soft-tissue sarcoma. Despite advances in knowledge and treatment of this disease, there remains a need for more effective LS therapy. Steroid hormone receptor...

    Davis R Ingram, Lloye M Dillon, Dina Chelouche Lev, Alexander Lazar, Elizabeth G Demicco, Burton L Eisenberg and Todd W Miller

    BMC Clinical Pathology 2014 14:42

    Published on: 22 October 2014

  16. Case report

    Limb girdle muscular dystrophy type 2G with myopathic-neurogenic motor unit potentials and a novel muscle image pattern

    Limb girdle muscular dystrophy type 2G (LGMD2G) is a subtype of autosomal recessive muscular dystrophy caused by mutations in the telethonin gene. There are few LGMD2G patients worldwide reported, and this is ...

    Ana Cotta, Julia Filardi Paim, Antonio Lopes da-Cunha-Junior, Rafael Xavier Neto, Simone Vilela Nunes, Monica Magalhaes Navarro, Jaquelin Valicek, Elmano Carvalho, Lydia U Yamamoto, Camila F Almeida, Shelida Vasconcelos Braz, Reinaldo Issao Takata and Mariz Vainzof

    BMC Clinical Pathology 2014 14:41

    Published on: 4 October 2014

  17. Research article

    Implant based differences in adverse local tissue reaction in failed total hip arthroplasties: a morphological and immunohistochemical study

    Adverse local tissue reaction (ALTR) is characterized by periprosthetic soft tissue inflammation composed of a mixed inflammatory cell infiltrate, extensive soft tissue necrosis, and vascular changes. Multiple...

    Giorgio Perino, Benjamin F Ricciardi, Seth A Jerabek, Guido Martignoni, Gabrielle Wilner, Dan Maass, Steven R Goldring and P Edward Purdue

    BMC Clinical Pathology 2014 14:39

    Published on: 5 September 2014

  18. Research article

    Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma

    Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lympho...

    Anna M Wirsing, Oddveig G Rikardsen, Sonja E Steigen, Lars Uhlin-Hansen and Elin Hadler-Olsen

    BMC Clinical Pathology 2014 14:38

    Published on: 23 August 2014

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