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  1. Case report

    Primary leiomyosarcoma of the submandibular gland: a case report

    Leiomyosarcoma is a rare malignant mesenchymal tumor that represents 5–7 % of all soft tissue sarcomas. The occurrence of this tumor in the salivary glands is exceptional. Only five cases are reported in the s...

    Mohamed Reda El Ochi, Hafsa Chahdi, Issam Rharrassi, Abderrahman Albouzidi and Mohamed Oukabli

    BMC Clinical Pathology 2015 15:22

    Published on: 15 December 2015

  2. Research article

    Expression of a-Tocopherol-Associated protein (TAP) is associated with clinical outcome in breast cancer patients

    The role of vitamin E in breast cancer prevention and treatment has been widely investigated, and the different tocopherols that comprise this nutrient have been shown to have divergent associations with cance...

    Xi Wang, Brian Z. Ring, Robert S. Seitz, Douglas T. Ross, Kirsten Woolf, Rodney A. Beck, David G. Hicks and Shuyuan Yeh

    BMC Clinical Pathology 2015 15:21

    Published on: 9 December 2015

  3. Research article

    Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer

    Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, PIK3CA, is one of the most frequently mutated genes in breast cancer, and the mutation status of PIK3CA has clinical relevance related to r...

    Ruza Arsenic, Denise Treue, Annika Lehmann, Michael Hummel, Manfred Dietel, Carsten Denkert and Jan Budczies

    BMC Clinical Pathology 2015 15:20

    Published on: 18 November 2015

  4. Research article

    Membranous CD24 expression as detected by the monoclonal antibody SWA11 is a prognostic marker in non-small cell lung cancer patients

    Lung cancer is one of the most common malignant neoplasms worldwide and has a high mortality rate. To enable individualized therapy regimens, a better understanding of the molecular tumor biology has still to ...

    Michael Majores, Anne Schindler, Angela Fuchs, Johannes Stein, Lukas Heukamp, Peter Altevogt and Glen Kristiansen

    BMC Clinical Pathology 2015 15:19

    Published on: 16 November 2015

  5. Research article

    Comparing gene expression data from formalin-fixed, paraffin embedded tissues and qPCR with that from snap-frozen tissue and microarrays for modeling outcomes of patients with ovarian carcinoma

    Previously, we have used clinical and gene expression data from The Cancer Genome Atlas (TCGA) to model a pathway-based index predicting outcomes in ovarian carcinoma. This data were obtained from snap-frozen ...

    William H. Bradley, Kevin Eng, Min Le, A. Craig Mackinnon, Christina Kendziorski and Janet S. Rader

    BMC Clinical Pathology 2015 15:17

    Published on: 24 September 2015

  6. Research article

    Prevalence and predictors of Pap smear cervical epithelial cell abnormality among HIV-positive and negative women attending gynecological examination in cervical cancer screening center at Debre Markos referral hospital, East Gojjam, Northwest Ethiopia

    Cervical cancer is the leading cause of cancer related death among women in developing countries. Cervical cancer is preceded by cervical surface epithelial cell abnormalities (ECA) which can be detected by Pa...

    Melkamu Getinet, Baye Gelaw, Abinet Sisay, Eiman A. Mahmoud and Abate Assefa

    BMC Clinical Pathology 2015 15:16

    Published on: 23 September 2015

  7. Case report

    Ruptured hepatic metastases of cutaneous melanoma during treatment with vemurafenib: an autopsy case report

    The spontaneous rupture of hepatic metastases is rare compared to that of primary hepatic tumors. In addition, vemurafenib, a selective inhibitor of the mutant BRAF protein or gene product, has been reported t...

    Takuto Nosaka, Katsushi Hiramatsu, Tomoyuki Nemoto, Yasushi Saito, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Hiroyuki Suto, Yoshiaki Imamura and Yasunari Nakamoto

    BMC Clinical Pathology 2015 15:15

    Published on: 3 September 2015

  8. Research article

    A retrospective analysis of breast cancer subtype based on ER/PR and HER2 status in Ghanaian patients at the Korle Bu Teaching Hospital, Ghana

    Breast cancer is a heterogeneous disease composed of multiple subgroups with different molecular alterations, cellular composition, clinical behaviour, and response to treatment. This study evaluates the occur...

    Bernard Seshie, Nii Armah Adu-Aryee, Florence Dedey, Benedict Calys-Tagoe and Joe-Nat Clegg-Lamptey

    BMC Clinical Pathology 2015 15:14

    Published on: 9 July 2015

  9. Research article

    Histological findings in infants with Gastrointestinal food allergy are associated with specific gastrointestinal symptoms; retrospective review from a tertiary centre

    Gastrointestinal food allergy (GIFA) occurs in 2 to 4 % of children, the majority of whom are infants (<1 year of age). Although endoscopy is considered the gold standard for diagnosing GIFA, it is invasive an...

    Neil Shah, Ru-Xin Melanie Foong, Osvaldo Borrelli, Eleni Volonaki, Robert Dziubak, Rosan Meyer, Mamoun Elawad and Neil J. Sebire

    BMC Clinical Pathology 2015 15:12

    Published on: 16 June 2015

  10. Research article

    Impact of add-on laboratory testing at an academic medical center: a five year retrospective study

    Clinical laboratories frequently receive orders to perform additional tests on existing specimens (‘add-ons’). Previous studies have examined add-on ordering patterns over short periods of time. The objective ...

    Louis S. Nelson, Scott R. Davis, Robert M. Humble, Jeff Kulhavy, Dean R. Aman and Matthew D. Krasowski

    BMC Clinical Pathology 2015 15:11

    Published on: 7 June 2015

  11. Research article

    Prognostic and predictive significance of podocalyxin-like protein expression in pancreatic and periampullary adenocarcinoma

    Adenocarcinoma of the periampullary region is associated with poor prognosis and new prognostic and treatment predictive biomarkers are needed for improved treatment. Membranous expression of podocalyxin-like ...

    Margareta Heby, Jakob Elebro, Björn Nodin, Karin Jirström and Jakob Eberhard

    BMC Clinical Pathology 2015 15:10

    Published on: 30 May 2015

  12. Research article

    Tumor-specific expression of HMG-CoA reductase in a population-based cohort of breast cancer patients

    The mevalonate pathway synthetizes cholesterol, steroid hormones, and non-steriod isoprenoids necessary for cell survival. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is the rate-limiting enzyme of...

    Emma Gustbée, Helga Tryggvadottir, Andrea Markkula, Maria Simonsson, Björn Nodin, Karin Jirström, Carsten Rose, Christian Ingvar, Signe Borgquist and Helena Jernström

    BMC Clinical Pathology 2015 15:8

    Published on: 20 May 2015

  13. Technical advance

    A reliable method for the detection of BRCA1 and BRCA2 mutations in fixed tumour tissue utilising multiplex PCR-based targeted next generation sequencing

    Germline mutations in BRCA1 or BRCA2 lead to a high lifetime probability of developing ovarian or breast cancer. These genes can also be involved in the development of non-hereditary tumours as somatic BRCA1/2 pa...

    Gillian Ellison, Shuwen Huang, Hedley Carr, Andrew Wallace, Miika Ahdesmaki, Sanjeev Bhaskar and John Mills

    BMC Clinical Pathology 2015 15:5

    Published on: 24 March 2015

  14. Research article

    Length of prostate biopsies is not necessarily compromised by pooling multiple cores in one paraffin block: an observational study

    Individually submitted prostatic needle biopsies are recommended by most guidelines because of their potential advantage in terms of core quality. However, unspecified bilateral biopsies are commonly submitted...

    Teemu T Tolonen, Jorma Isola, Antti Kaipia, Jarno Riikonen, Laura Koivusalo, Sanna Huovinen, Marita Laurila, Sinikka Porre, Mika Tirkkonen and Paula Kujala

    BMC Clinical Pathology 2015 15:4

    Published on: 8 March 2015

  15. Research article

    SOD2 immunoexpression predicts lymph node metastasis in penile cancer

    Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme in lung, gastric, col...

    Lara Termini, José H Fregnani, Enrique Boccardo, Walter H da Costa, Adhemar Longatto-Filho, Maria A Andreoli, Maria C Costa, Ademar Lopes, Isabela W da Cunha, Fernando A Soares, Luisa L Villa and Gustavo C Guimarães

    BMC Clinical Pathology 2015 15:3

    Published on: 3 March 2015

  16. Case report

    Primary gastric actinomycosis: report of a case diagnosed in a gastroscopic biopsy

    Primary gastric actinomycosis is extremely rare, the appendix and ileocecal region being the most commonly involved sites in abdominopelvic actinomycosis. Herein, we report a case of primary gastric actinomyco...

    Khaleel Al-Obaidy, Fatimah Alruwaii, Areej Al Nemer, Raed Alsulaiman, Zainab Alruwaii and Mohamed A Shawarby

    BMC Clinical Pathology 2015 15:2

    Published on: 26 February 2015

  17. Research article

    Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival

    Dicer and Drosha are important enzymes for processing microRNAs. Recent studies have exhibited possible links between expression of different miRNAs, levels of miRNA processing enzymes, and cancer prognosis. W...

    Kenneth Lønvik, Sveinung W Sørbye, Marit N Nilsen and Ruth H Paulssen

    BMC Clinical Pathology 2014 14:45

    Published on: 11 December 2014

  18. Research article

    Practice of percutaneous needle autopsy; a descriptive study reporting experiences from Uganda

    Percutaneous needle autopsy can overcome a number of barriers that limit the use of complete autopsies. We performed blind-and ultrasound guided needle autopsies in HIV-infected adults in Uganda. In this study...

    Janneke A Cox, Robert L Lukande, Sam Kalungi, Koen Van de Vijver, Eric Van Marck, Ann M Nelson, Asafu Munema, Yukari C Manabe and Robert Colebunders

    BMC Clinical Pathology 2014 14:44

    Published on: 3 December 2014

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