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  1. Research article

    High expression of EphA3 (erythropoietin-producing hepatocellular A3) in gastric cancer is associated with metastasis and poor survival

    As the major subfamily of receptor tyrosine, erythropoietin-producing hepatocellular (Eph) receptor has been related to progression and prognosis in different types of tumors. However, the role and mechanism o...

    Baongoc Nasri, Mikito Inokuchi, Toshiaki Ishikawa, Hiroyuki Uetake, Yoko Takagi, Sho Otsuki, Kazuyuki Kojima and Tatsuyuki Kawano

    BMC Clinical Pathology 2017 17:8

    Published on: 27 April 2017

  2. Technical advance

    Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture micro-dissection and cycling temperature capillary electrophoresis

    The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mit...

    Paulo Refinetti, Christian Arstad, William G. Thilly, Stephan Morgenthaler and Per Olaf Ekstrøm

    BMC Clinical Pathology 2017 17:6

    Published on: 8 April 2017

  3. Case report

    Bone pathologic fracture revealing an unusual association: coexistence of Langerhans cell histiocytosis with Rosai-Dorfman disease

    The coexistence of Rosai-Dorfman disease (RDD) with Langerhans cell histiocytosis (LCH) is very rare, as to date only 17 cases have been reported in the english literature. The pathophysiology of this uncommon...

    Boubacar Efared, Asmae Mazti, Badarou Chaibou, Gabrielle Atsame-Ebang, Ibrahim Sory Sidibé, Layla Tahiri, Fatimazahra Erregad, Nawal Hammas, Abdelmajid El Mrini, Hinde El Fatemi and Laila Chbani

    BMC Clinical Pathology 2017 17:5

    Published on: 7 April 2017

  4. Research article

    Expression of human epidermal growth factor receptor 2 in bladder urothelial carcinoma

    Urothelial bladder carcinoma (UBC) is one of the most prevalent cancers in men worldwide. Human epidermal growth factor receptor 2 (HER2) expression has been detected in a wide range of urothelial carcinoma. D...

    Mohamed Reda El Ochi, Mohamed Oukabli, Elarbi Bouaiti, Hafsa Chahdi, Adil Boudhas, Mohamed Allaoui, Ahmed Ameur, Mohamed Abbar and Abderrahmane Al Bouzidi

    BMC Clinical Pathology 2017 17:3

    Published on: 4 April 2017

  5. Research article

    Peritumoral lymphatic vessel density and invasion detected with immunohistochemical marker D240 is strongly associated with distant metastasis in breast carcinoma

    Detection of vascular invasion by hematoxylin and eosin staining is the current pathological assessment practice to diagnose breast carcinoma. However, conventional hematoxylin and eosin staining failed to dis...

    Nur Fatiha Norhisham, Choi Yen Chong and Sabreena Safuan

    BMC Clinical Pathology 2017 17:2

    Published on: 10 February 2017

  6. Case report

    Mycetoma in a non-endemic area: a diagnostic challenge

    Mycetoma is a chronic granulomatous infectious disease caused by filamentous bacteria or by fungi. The disease is endemic in certain tropical and subtropical areas of the world but can be found elsewhere posin...

    Boubacar Efared, Layla Tahiri, Marou Soumana Boubacar, Gabrielle Atsam-Ebang, Nawal Hammas, El Fatemi Hinde and Laila Chbani

    BMC Clinical Pathology 2017 17:1

    Published on: 2 February 2017

  7. Research article

    Nucleic acid extraction from formalin-fixed paraffin-embedded cancer cell line samples: a trade off between quantity and quality?

    Advanced genomic techniques such as Next-Generation-Sequencing (NGS) and gene expression profiling, including NanoString, are vital for the development of personalised medicines, as they enable molecular disea...

    Caroline Seiler, Alan Sharpe, J. Carl Barrett, Elizabeth A. Harrington, Emma V. Jones and Gayle B. Marshall

    BMC Clinical Pathology 2016 16:17

    Published on: 14 November 2016

  8. Research article

    Oxidative profile of sickle cell patients in a Cameroonian urban hospital

    Sickle cell disease (SCD) is a class of hemoglobinopathy resulting from a single mutation in the ß-globin chain inducing the substitution of valine for glutamic acid at the sixth amino acid position which lead...

    Vicky Jocelyne Ama Moor, Constant Anatole Pieme, Bernard Chetcha Chemegne, Helene Manonji, Borgia Legrand Njinkio Nono, Corine Tchoula Mamiafo, Bruno Moukette Moukette, Francine Tankeu Nzufo and Asonganyi Tazoacha

    BMC Clinical Pathology 2016 16:15

    Published on: 21 September 2016

  9. Research article

    Dried blood spot omega-3 and omega-6 long chain polyunsaturated fatty acid levels in 7–9 year old Zimbabwean children: a cross sectional study

    Omega-3 long chain-polyunsaturated fatty acids (LC-PUFAs)–docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and eicosapentaenoic acid (EPA)– and omega-6 LC-PUFA arachidonic acid (ARA), are essential for ...

    Grace Mashavave, Patience Kuona, Willard Tinago, Babill Stray-Pedersen, Marshall Munjoma and Cuthbert Musarurwa

    BMC Clinical Pathology 2016 16:14

    Published on: 5 August 2016

  10. Research article

    Expression of podocalyxin-like protein is an independent prognostic biomarker in resected esophageal and gastric adenocarcinoma

    Podocalyxin-like protein (PODXL) is a cell surface transmembrane glycoprotein, the expression of which has been associated with poor prognosis in a range of malignancies. The aim of this study was to investiga...

    David Borg, Charlotta Hedner, Björn Nodin, Anna Larsson, Anders Johnsson, Jakob Eberhard and Karin Jirström

    BMC Clinical Pathology 2016 16:13

    Published on: 29 July 2016

  11. Research article

    The study of calcified atherosclerotic arteries: an alternative to evaluate the composition of a problematic tissue reveals new insight including metakaryotic cells

    Calcifications of atherosclerotic plaques represent a controversial issue as they either lead to the stabilization or rupture of the lesion. However, the cellular key players involved in the progression of the...

    Silvia Fittipaldi, Francesco Vasuri, Alessio Degiovanni, Rodolfo Pini, Mauro Gargiulo, Andrea Stella, Gianandrea Pasquinelli, William G. Thilly and Elena V. Gostjeva

    BMC Clinical Pathology 2016 16:12

    Published on: 29 July 2016

  12. Research article

    Histopathological techniques for the diagnosis of combat-related invasive fungal wound infections

    Effective management of trauma-related invasive fungal wound infections (IFIs) depends on early diagnosis and timely initiation of treatment. We evaluated the utility of routine staining, histochemical stains ...

    Sarah M. Heaton, Amy C. Weintrob, Kevin Downing, Bryan Keenan, Deepak Aggarwal, Faraz Shaikh, David R. Tribble and Justin Wells

    BMC Clinical Pathology 2016 16:11

    Published on: 7 July 2016

  13. Research article

    5-type HPV mRNA versus 14-type HPV DNA test: test performance, over-diagnosis and overtreatment in triage of women with minor cervical lesions

    Repeat cytology and HPV testing is used in triage of women with minor cytological lesions. The objective of this study was to evaluate 14-type HPV DNA and 5-type HPV mRNA testing in delayed triage of women wit...

    Bjørn Westre, Anita Giske, Hilde Guttormsen, Sveinung Wergeland Sørbye and Finn Egil Skjeldestad

    BMC Clinical Pathology 2016 16:9

    Published on: 7 June 2016

  14. Case report

    Liver cancer with concomitant TP53 and CTNNB1 mutations: a case report

    In the spectrum of molecular alterations found in hepatocellular carcinoma (HCC), somatic mutations in the WNT/β-catenin pathway and the p53/cell cycle control pathway are among the most frequent ones. It has ...

    Juliane Friemel, Markus Rechsteiner, Marion Bawohl, Lukas Frick, Beat Müllhaupt, Mickaël Lesurtel and Achim Weber

    BMC Clinical Pathology 2016 16:7

    Published on: 1 June 2016

  15. Case report

    Primary Burkitt lymphoma of the thyroid gland: case report of an exceptional type of thyroid neoplasm and review of the literature

    Primary thyroid lymphoma is an uncommon pathological entity that accounts for only 1 to 5 % of all thyroid malignancies. Primary Burkitt lymphoma of the thyroid gland is very rare. This article presents the fi...

    Mohamed Allaoui, Ilias Benchafai, El Mehdi Mahtat, Safae Regragui, Adil Boudhas, Mustapha Azzakhmam, Mohammed Boukhechba, Abderrahmane Al Bouzidi and Mohamed Oukabli

    BMC Clinical Pathology 2016 16:6

    Published on: 11 May 2016

  16. Case report

    Bone metastasis from malignant phyllodes breast tumor: report of two cases

    Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. They are malignant in 20 % of cases. Only a few cases of malignant phyllodes tumors metastatic to bone hav...

    Mohamed Reda El Ochi, Mehdi Toreis, Mohamed Benchekroun, Zineb Benkerroum, Mohamed Allaoui, Mohamed Ichou, Basma El Khannoussi, Abderrahman Albouzidi and Mohamed Oukabli

    BMC Clinical Pathology 2016 16:4

    Published on: 29 February 2016

  17. Research article

    Histopathological characterization of corrosion product associated adverse local tissue reaction in hip implants: a study of 285 cases

    Adverse local tissue reaction (ALTR), characterized by a heterogeneous cellular inflammatory infiltrate and the presence of corrosion products in the periprosthetic soft tissues, has been recognized as a mecha...

    Benjamin F. Ricciardi, Allina A. Nocon, Seth A. Jerabek, Gabrielle Wilner, Elianna Kaplowitz, Steven R. Goldring, P. Edward Purdue and Giorgio Perino

    BMC Clinical Pathology 2016 16:3

    Published on: 27 February 2016

  18. Research article

    Quantitative assessment of placental morphology may identify specific causes of stillbirth

    Stillbirth is frequently the result of pathological processes involving the placenta. Understanding the significance of specific lesions is hindered by qualitative subjective evaluation. We hypothesised that q...

    Imogen Ptacek, Anna Smith, Ainslie Garrod, Sian Bullough, Nicola Bradley, Gauri Batra, Colin P. Sibley, Rebecca L. Jones, Paul Brownbill and Alexander E. P. Heazell

    BMC Clinical Pathology 2016 16:1

    Published on: 9 February 2016

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