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  1. Research article

    Peritumoral lymphatic vessel density and invasion detected with immunohistochemical marker D240 is strongly associated with distant metastasis in breast carcinoma

    Detection of vascular invasion by hematoxylin and eosin staining is the current pathological assessment practice to diagnose breast carcinoma. However, conventional hematoxylin and eosin staining failed to dis...

    Nur Fatiha Norhisham, Choi Yen Chong and Sabreena Safuan

    BMC Clinical Pathology 2017 17:2

    Published on: 10 February 2017

  2. Case report

    Mycetoma in a non-endemic area: a diagnostic challenge

    Mycetoma is a chronic granulomatous infectious disease caused by filamentous bacteria or by fungi. The disease is endemic in certain tropical and subtropical areas of the world but can be found elsewhere posin...

    Boubacar Efared, Layla Tahiri, Marou Soumana Boubacar, Gabrielle Atsam-Ebang, Nawal Hammas, El Fatemi Hinde and Laila Chbani

    BMC Clinical Pathology 2017 17:1

    Published on: 2 February 2017

  3. Research article

    Nucleic acid extraction from formalin-fixed paraffin-embedded cancer cell line samples: a trade off between quantity and quality?

    Advanced genomic techniques such as Next-Generation-Sequencing (NGS) and gene expression profiling, including NanoString, are vital for the development of personalised medicines, as they enable molecular disea...

    Caroline Seiler, Alan Sharpe, J. Carl Barrett, Elizabeth A. Harrington, Emma V. Jones and Gayle B. Marshall

    BMC Clinical Pathology 2016 16:17

    Published on: 14 November 2016

  4. Research article

    Oxidative profile of sickle cell patients in a Cameroonian urban hospital

    Sickle cell disease (SCD) is a class of hemoglobinopathy resulting from a single mutation in the ß-globin chain inducing the substitution of valine for glutamic acid at the sixth amino acid position which lead...

    Vicky Jocelyne Ama Moor, Constant Anatole Pieme, Bernard Chetcha Chemegne, Helene Manonji, Borgia Legrand Njinkio Nono, Corine Tchoula Mamiafo, Bruno Moukette Moukette, Francine Tankeu Nzufo and Asonganyi Tazoacha

    BMC Clinical Pathology 2016 16:15

    Published on: 21 September 2016

  5. Research article

    Dried blood spot omega-3 and omega-6 long chain polyunsaturated fatty acid levels in 7–9 year old Zimbabwean children: a cross sectional study

    Omega-3 long chain-polyunsaturated fatty acids (LC-PUFAs)–docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and eicosapentaenoic acid (EPA)– and omega-6 LC-PUFA arachidonic acid (ARA), are essential for ...

    Grace Mashavave, Patience Kuona, Willard Tinago, Babill Stray-Pedersen, Marshall Munjoma and Cuthbert Musarurwa

    BMC Clinical Pathology 2016 16:14

    Published on: 5 August 2016

  6. Research article

    Expression of podocalyxin-like protein is an independent prognostic biomarker in resected esophageal and gastric adenocarcinoma

    Podocalyxin-like protein (PODXL) is a cell surface transmembrane glycoprotein, the expression of which has been associated with poor prognosis in a range of malignancies. The aim of this study was to investiga...

    David Borg, Charlotta Hedner, Björn Nodin, Anna Larsson, Anders Johnsson, Jakob Eberhard and Karin Jirström

    BMC Clinical Pathology 2016 16:13

    Published on: 29 July 2016

  7. Research article

    The study of calcified atherosclerotic arteries: an alternative to evaluate the composition of a problematic tissue reveals new insight including metakaryotic cells

    Calcifications of atherosclerotic plaques represent a controversial issue as they either lead to the stabilization or rupture of the lesion. However, the cellular key players involved in the progression of the...

    Silvia Fittipaldi, Francesco Vasuri, Alessio Degiovanni, Rodolfo Pini, Mauro Gargiulo, Andrea Stella, Gianandrea Pasquinelli, William G. Thilly and Elena V. Gostjeva

    BMC Clinical Pathology 2016 16:12

    Published on: 29 July 2016

  8. Research article

    Histopathological techniques for the diagnosis of combat-related invasive fungal wound infections

    Effective management of trauma-related invasive fungal wound infections (IFIs) depends on early diagnosis and timely initiation of treatment. We evaluated the utility of routine staining, histochemical stains ...

    Sarah M. Heaton, Amy C. Weintrob, Kevin Downing, Bryan Keenan, Deepak Aggarwal, Faraz Shaikh, David R. Tribble and Justin Wells

    BMC Clinical Pathology 2016 16:11

    Published on: 7 July 2016

  9. Research article

    5-type HPV mRNA versus 14-type HPV DNA test: test performance, over-diagnosis and overtreatment in triage of women with minor cervical lesions

    Repeat cytology and HPV testing is used in triage of women with minor cytological lesions. The objective of this study was to evaluate 14-type HPV DNA and 5-type HPV mRNA testing in delayed triage of women wit...

    Bjørn Westre, Anita Giske, Hilde Guttormsen, Sveinung Wergeland Sørbye and Finn Egil Skjeldestad

    BMC Clinical Pathology 2016 16:9

    Published on: 7 June 2016

  10. Case report

    Liver cancer with concomitant TP53 and CTNNB1 mutations: a case report

    In the spectrum of molecular alterations found in hepatocellular carcinoma (HCC), somatic mutations in the WNT/β-catenin pathway and the p53/cell cycle control pathway are among the most frequent ones. It has ...

    Juliane Friemel, Markus Rechsteiner, Marion Bawohl, Lukas Frick, Beat Müllhaupt, Mickaël Lesurtel and Achim Weber

    BMC Clinical Pathology 2016 16:7

    Published on: 1 June 2016

  11. Case report

    Primary Burkitt lymphoma of the thyroid gland: case report of an exceptional type of thyroid neoplasm and review of the literature

    Primary thyroid lymphoma is an uncommon pathological entity that accounts for only 1 to 5 % of all thyroid malignancies. Primary Burkitt lymphoma of the thyroid gland is very rare. This article presents the fi...

    Mohamed Allaoui, Ilias Benchafai, El Mehdi Mahtat, Safae Regragui, Adil Boudhas, Mustapha Azzakhmam, Mohammed Boukhechba, Abderrahmane Al Bouzidi and Mohamed Oukabli

    BMC Clinical Pathology 2016 16:6

    Published on: 11 May 2016

  12. Case report

    Bone metastasis from malignant phyllodes breast tumor: report of two cases

    Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. They are malignant in 20 % of cases. Only a few cases of malignant phyllodes tumors metastatic to bone hav...

    Mohamed Reda El Ochi, Mehdi Toreis, Mohamed Benchekroun, Zineb Benkerroum, Mohamed Allaoui, Mohamed Ichou, Basma El Khannoussi, Abderrahman Albouzidi and Mohamed Oukabli

    BMC Clinical Pathology 2016 16:4

    Published on: 29 February 2016

  13. Research article

    Histopathological characterization of corrosion product associated adverse local tissue reaction in hip implants: a study of 285 cases

    Adverse local tissue reaction (ALTR), characterized by a heterogeneous cellular inflammatory infiltrate and the presence of corrosion products in the periprosthetic soft tissues, has been recognized as a mecha...

    Benjamin F. Ricciardi, Allina A. Nocon, Seth A. Jerabek, Gabrielle Wilner, Elianna Kaplowitz, Steven R. Goldring, P. Edward Purdue and Giorgio Perino

    BMC Clinical Pathology 2016 16:3

    Published on: 27 February 2016

  14. Research article

    Quantitative assessment of placental morphology may identify specific causes of stillbirth

    Stillbirth is frequently the result of pathological processes involving the placenta. Understanding the significance of specific lesions is hindered by qualitative subjective evaluation. We hypothesised that q...

    Imogen Ptacek, Anna Smith, Ainslie Garrod, Sian Bullough, Nicola Bradley, Gauri Batra, Colin P. Sibley, Rebecca L. Jones, Paul Brownbill and Alexander E. P. Heazell

    BMC Clinical Pathology 2016 16:1

    Published on: 9 February 2016

  15. Case report

    Primary leiomyosarcoma of the submandibular gland: a case report

    Leiomyosarcoma is a rare malignant mesenchymal tumor that represents 5–7 % of all soft tissue sarcomas. The occurrence of this tumor in the salivary glands is exceptional. Only five cases are reported in the s...

    Mohamed Reda El Ochi, Hafsa Chahdi, Issam Rharrassi, Abderrahman Albouzidi and Mohamed Oukabli

    BMC Clinical Pathology 2015 15:22

    Published on: 15 December 2015

  16. Research article

    Expression of a-Tocopherol-Associated protein (TAP) is associated with clinical outcome in breast cancer patients

    The role of vitamin E in breast cancer prevention and treatment has been widely investigated, and the different tocopherols that comprise this nutrient have been shown to have divergent associations with cance...

    Xi Wang, Brian Z. Ring, Robert S. Seitz, Douglas T. Ross, Kirsten Woolf, Rodney A. Beck, David G. Hicks and Shuyuan Yeh

    BMC Clinical Pathology 2015 15:21

    Published on: 9 December 2015

  17. Research article

    Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer

    Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, PIK3CA, is one of the most frequently mutated genes in breast cancer, and the mutation status of PIK3CA has clinical relevance related to r...

    Ruza Arsenic, Denise Treue, Annika Lehmann, Michael Hummel, Manfred Dietel, Carsten Denkert and Jan Budczies

    BMC Clinical Pathology 2015 15:20

    Published on: 18 November 2015

  18. Research article

    Membranous CD24 expression as detected by the monoclonal antibody SWA11 is a prognostic marker in non-small cell lung cancer patients

    Lung cancer is one of the most common malignant neoplasms worldwide and has a high mortality rate. To enable individualized therapy regimens, a better understanding of the molecular tumor biology has still to ...

    Michael Majores, Anne Schindler, Angela Fuchs, Johannes Stein, Lukas Heukamp, Peter Altevogt and Glen Kristiansen

    BMC Clinical Pathology 2015 15:19

    Published on: 16 November 2015

  19. Research article

    Comparing gene expression data from formalin-fixed, paraffin embedded tissues and qPCR with that from snap-frozen tissue and microarrays for modeling outcomes of patients with ovarian carcinoma

    Previously, we have used clinical and gene expression data from The Cancer Genome Atlas (TCGA) to model a pathway-based index predicting outcomes in ovarian carcinoma. This data were obtained from snap-frozen ...

    William H. Bradley, Kevin Eng, Min Le, A. Craig Mackinnon, Christina Kendziorski and Janet S. Rader

    BMC Clinical Pathology 2015 15:17

    Published on: 24 September 2015

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