Time to recurrence | Overall survival | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Unadjusted | Adjusted | Unadjusted | Adjusted | |||||||
n (events) | HR (95 % CI) | p-value | HR (95 % CI) | p-value | n (events) | HR (95 % CI) | p-value | HR (95 % CI) | p-value | |
Age | ||||||||||
Continuous | 136 (72) | 1.00 (0.98–1.02) | 0.610 | 151 (104) | 1.04 (1.02–1.06) | <0.001 | 1.05 (1.03–1.07) | <0.001 | ||
Sex | ||||||||||
Female | 27 (12) | 30 (22) | ||||||||
Male | 109 (60) | 1.18 (0.63–2.19) | 0.610 | 121 (82) | 0.81 (0.50–1.29) | 0.370 | ||||
T stage | <0.001 | 0.043 | 0.010 | 0.511 | ||||||
T1 | 18 (3) | 19 (7) | ||||||||
T2 | 27 (8) | 2.14 (0.57–8.06) | 0.263 | 1.53 (0.39–5.96) | 0.538 | 30 (19) | 2.09 (0.88–4.97) | 0.097 | 1.53 (0.62–3.78) | 0.357 |
T3 | 77 (51) | 6.92 (2.15–22.29) | 0.001 | 3.72 (1.10–12.64) | 0.035 | 86 (66) | 3.27 (1.49–7.15) | 0.003 | 1.79 (0.79–4.08) | 0.164 |
T4 | 14 (10) | 8.52 (2.33–31.16) | 0.001 | 3.52 (0.92–13.56) | 0.067 | 16 (12) | 3.71 (1.45–9.48) | 0.006 | 1.98 (0.74–5.31) | 0.175 |
N stage | ||||||||||
N0 | 50 (7) | 53 (26) | ||||||||
N1-3 | 86 (65) | 9.89 (4.51–21.72) | <0.001 | 7.78 (3.24–18.71) | <0.001 | 98 (78) | 2.56 (1.63–4.00) | <0.001 | 2.79 (1.67–4.66) | <0.001 |
R classification | ||||||||||
R0 | 103 (46) | 113 (69) | ||||||||
R1 | 33 (26) | 2.89 (1.76–4.74) | <0.001 | 1.38 (0.79–2.41) | 0.253 | 38 (35) | 2.75 (1.80–4.20) | <0.001 | 2.07 (1.29–3.31) | 0.003 |
Differentiation grade | ||||||||||
Low/Intermediate grade | 49 (18) | 56 (31) | ||||||||
High grade | 87 (54) | 2.22 (1.30–3.79) | 0.004 | 1.93 (1.09–3.42) | 0.025 | 95 (73) | 1.73 (1.13–2.63) | 0.011 | 1.40 (0.88–2.20) | 0.153 |
Lauren classification | ||||||||||
Intestinal | 94 (45) | 106 (69) | ||||||||
Diffuse/Mixed | 42 (27) | 1.57 (0.97–2.53) | 0.064 | 45 (35) | 1.35 (0.90–2.03) | 0.149 | ||||
Adjuvant treatment | ||||||||||
No | 126 (63) | 138 (94) | ||||||||
Chemo-/radiotherapy | 10 (9) | 2.12 (1.05–4.28) | 0.036 | 0.96 (0.45–2.06) | 0.924 | 13 (10) | 1.20 (0.62–2.30) | 0.589 | ||
Location | ||||||||||
Esophagus + EG junction | 86 (49) | 99 (69) | ||||||||
Stomach | 50 (23) | 0.74 (0.45–1.22) | 0.239 | 52 (35) | 0.90 (0.60–1.34) | 0.592 | ||||
PODXL expression | ||||||||||
Negative | 20 (3) | 24 (10) | ||||||||
Positive | 113 (67) | 5.36 (1.68–17.06) | 0.005 | 3.39 (1.01–11.35) | 0.048 | 124 (92) | 2.52 (1.31–4.85) | 0.006 | 2.03 (1.04–3.98) | 0.039 |