P53 nuclear stabilization is associated with FHIT loss and younger age of onset in squamous cell carcinoma of oral tongue

Table 5 Association of p53 nuclear stabilization and FHIT loss with disease specific survival of SCCOT patients

	Total (n)	Dead (n)	% Dead	Median survival (months)	Hazard ratio^a	95% CI	Significance^b
Total	79	42	53.16
P53 nuclear stabilization
NS-	30	10	33.3	63	-	-	0.0003
NS+	49	32	65.31	26.5	3.35.1	1.8293-6.1350	0.0003
P53 mutation
Mutation	18	12	66.67	22			0.0117
No mutation	43	22	51.16	38	0.4274	0.1811 to 1.0084	0.0117
*FHIT* LOH
LOH	20	13	65	21	-	-	0.0302
No LOH	53	27	50.94	38	0.4967	0.2265-1.0893

^aHazard ratio was calculated to the first variable in a subgroup (indicated by empty cells).
^bCorresponds to Log Rank test (Mantel-Cox).

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