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Table 6 Association of alphaB-crystallin protein expression with all examined markers

From: alphaB-crystallin is a marker of aggressive breast cancer behavior but does not independently predict for patient outcome: a combined analysis of two randomized studies

 

alphaB-crystallin

 
 

N (%)

N (%)

N (%)

 
 

Negative

Weakly positive

Strongly positive

p-value (Pearson chi-square)

ER (n = 938)

   

<0.001

 Negative

176 (71.8)

38 (15.5)

31 (12.7)

 

 Positive

592 (85.4)

61 (8.8)

40 (5.8)

 

PgR (n = 940)

   

<0.001

 Negative

227 (75.4)

38 (12.6)

36 (12.0)

 

 Positive

543 (85.0)

61 (9.5)

35 (5.5)

 

Ki67 (n = 934)

   

<0.001

 Low

267 (89.3)

17 (5.7)

15 (5.0)

 

 High

499 (78.6)

81 (12.8)

55 (8.6)

 

BRCA1 (n = 928)

   

0.676

 Negative

707 (81.9)

91 (10.6)

65 (7.5)

 

 Positive

52 (80.0)

7 (10.8)

6 (9.2)

 

BRCA1 (n = 86)

   

0.045

 WT

61 (78.2)

11 (14.1)

6 (7.7)

 

 Mutated

4 (50.0)

1 (12.5)

3 (37.5)

 

p53 (n = 918)

   

0.002

 Negative

384 (86.3)

32 (7.2)

29 (6.5)

 

 Positive

370 (78.2)

66 (14.0)

37 (7.8)

 

EGFR (n = 928)

   

<0.001

 Negative

671 (86.3)

65 (8.4)

41 (5.3)

 

 Positive

91 (60.3)

32 (21.2)

28 (18.5)

 

CK5 (n = 923)

   

<0.001

 Negative

694 (86.5)

67 (8.4)

41 (5.1)

 

 Positive

63 (52.1)

31 (25.6)

27 (22.3)

 

CK14 (n = 925)

   

<0.001

 Negative

750 (83.9)

88 (9.8)

56 (6.3)

 

 Positive

9 (29.0)

10 (32.3)

12 (38.7)

 

CK17 (n = 909)

   

<0.001

 Negative

742 (83.9)

87 (9.9)

55 (6.2)

 

 Positive

5 (20.0)

9 (36.0)

11 (44)

 
  1. WT, wild-type.
  2. Significant p-values are shown in bold.