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  1. Vertebral fractures resulting from high energy trauma often comprise the risk of posttraumatic degenerative changes in the affected intervertebral discs (IVD). Particularly in conservatively treated patients, ...

    Authors: Christoph-E Heyde, Sven K Tschoeke, Markus Hellmuth, Arwed Hostmann, Wolfgang Ertel and Andreas Oberholzer

    Citation: BMC Clinical Pathology 2006 6:5

    Content type: Research article

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  2. Only prototypes 5 years ago, high-speed, automated whole slide imaging (WSI) systems (also called digital slide systems, virtual microscopes or wide field imagers) are becoming increasingly capable and robust....

    Authors: John R Gilbertson, Jonhan Ho, Leslie Anthony, Drazen M Jukic, Yukako Yagi and Anil V Parwani

    Citation: BMC Clinical Pathology 2006 6:4

    Content type: Technical advance

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  3. Cytokine production is critical in ischemia/reperfusion (IR) injury. Acetylcholine binds to macrophages and inhibits cytokine synthesis, through the cholinergic anti-inflammatory pathway. This study examined t...

    Authors: Elahé T Crockett, James J Galligan, Bruce D Uhal, Jack Harkema, Robert Roth and Kinnari Pandya

    Citation: BMC Clinical Pathology 2006 6:3

    Content type: Research article

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  4. The clinical benefit of determining the status of HER-2/neu amplification in breast cancer patients is well accepted. Although immunohistochemistry (IHC) is the most frequently used method to assess the over-expr...

    Authors: Andreea Nistor, Peter H Watson, Norman Pettigrew, Karim Tabiti, Angelika Dawson and Yvonne Myal

    Citation: BMC Clinical Pathology 2006 6:2

    Content type: Research article

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  5. Distinguishing endocervical adenocarcinoma (ECA) from endometrial mucinous adenocarcinoma (EMMA) is clinically significant in view of the differences in their management and prognosis. In this study, we used a...

    Authors: Thaer Khoury, Dongfeng Tan, Jianmin Wang, Marilyn Intengan, Jun Yang, Sadir Alrawi, Peisha Yan and James C Byrd

    Citation: BMC Clinical Pathology 2006 6:1

    Content type: Research article

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  6. Lymph node infarction is known to occur in association with many non-neoplastic and neoplastic conditions however its occurrence in association with DIC is not reported hitherto in the literature.

    Authors: I Satish Rao, Anand C Loya, KS Ratnakar and VR Srinivasan

    Citation: BMC Clinical Pathology 2005 5:11

    Content type: Case report

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  7. The GP5+/GP6+ PCR assay is a well-established HPV detection technique. This study has examined the effects of incorporating 'hot start' and 'touchdown' steps into the protocol. In addition, dTTP was substitute...

    Authors: Mark F Evans, Christine SC Adamson, Linda Simmons-Arnold and Kumarasen Cooper

    Citation: BMC Clinical Pathology 2005 5:10

    Content type: Technical advance

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  8. The aim of our study was to objectively compare Cytyc Thinprep® and other methods of obtaining thin layer cytologic preparations (cytocentrifugation, direct smearing and Millipore® filtration) in urine cytopathol...

    Authors: Eric Piaton, Jacqueline Faÿnel, Karine Hutin, Marie-Claude Ranchin and Michèle Cottier

    Citation: BMC Clinical Pathology 2005 5:9

    Content type: Technical advance

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  9. For solid tumors, image cytometry has been shown to be more sensitive for diagnosing DNA content abnormalities (aneuploidy) than flow cytometry. Image cytometry has often been performed using the semi-automate...

    Authors: Qin Huang, Chenggong Yu, Michael Klein, James Fang and Raj K Goyal

    Citation: BMC Clinical Pathology 2005 5:7

    Content type: Technical advance

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  10. Oligodendroglioma (ODG) and oligoastrocytoma (OAC) are diffusely infiltrating primary brain tumors whose pathogenesis remains unclear. We previously identified a group of genes whose expression was inversely c...

    Authors: Yu Liang, Andrew W Bollen, M Kelly Nicholas and Nalin Gupta

    Citation: BMC Clinical Pathology 2005 5:6

    Content type: Research article

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  11. Lower vaccination coverage among foreign-born children is of concern because they live in households and communities characterized by more intense exposure to infectious diseases. Because of their higher preva...

    Authors: George Briassoulis, Athina Tsorva, Emmanuel Agapitos and John Papadatos

    Citation: BMC Clinical Pathology 2005 5:5

    Content type: Case report

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  12. the classification criteria for primary Sjögren's syndrome (pSS) include a number of oral components. In this study we evaluated if salivary flow and composition as well as dental caries are oral markers of di...

    Authors: Anne Marie Lynge Pedersen, Allan Bardow and Birgitte Nauntofte

    Citation: BMC Clinical Pathology 2005 5:4

    Content type: Research article

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  13. G1/S cell cycle progression requires p27Kip1 (p27) proteolysis, which is triggered by its phosphorylation on threonine (Thr) 187. Since its levels are abundant in quiescent and scarce in cycling cells, p27 is an ...

    Authors: Giancarlo Troncone, Juan C Martinez, Antonino Iaccarino, Pio Zeppa, Alessia Caleo, Maria Russo, Ilenia Migliaccio, Maria L Motti, Daniela Califano, Emiliano A Palmieri and Lucio Palombini

    Citation: BMC Clinical Pathology 2005 5:3

    Content type: Research article

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  14. Results of previous autopsy studies indicate that increased hepatic iron stores or hepatic iron overload is common in African Americans dying in hospitals, but there are no reports of hepatic iron content in o...

    Authors: James C Barton, Ronald T Acton, Asia K Richardson and Robert M Brissie

    Citation: BMC Clinical Pathology 2005 5:2

    Content type: Research article

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  15. The assessment of tumor invasion of underlying benign stroma in neoplastic squamous proliferation of the larynx may pose a diagnostic challenge, particularly in small biopsy specimens that are frequently tange...

    Authors: Mahmoud Said, Sam Wiseman, Jun Yang, Sadir Alrawi, Wade Douglas, Richard Cheney, Wesley Hicks, Nestor Rigual, Thom Loree, Gregory Spiegel and Dongfeng Tan

    Citation: BMC Clinical Pathology 2005 5:1

    Content type: Research article

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  16. Neutrophil infiltration is one of the critical cellular components of an inflammatory response during peritonitis. The adhesion molecules, P-selectin and intercellular adhesion molecule (ICAM)-1, mediate neutr...

    Authors: Elahé T Crockett, Crystal Remelius, Karen Hess and Hayma Al-Ghawi

    Citation: BMC Clinical Pathology 2004 4:2

    Content type: Research article

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  17. The purpose of the present correlative immunohistochemical study was to assess the utility of cytokeratin (CK7 and CK20) expression in the diagnosis of short-segment Barrett esophagus, particularly its efficac...

    Authors: Ozlem Kurtkaya-Yapicier, Rasim Gencosmanoglu, Erol Avsar, Nadi Bakirci, Nurdan Tozun and Aydin Sav

    Citation: BMC Clinical Pathology 2003 3:5

    Content type: Research article

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  18. Growth factor, cytokine and chemokine-induced activation of PI3K enzymes constitutes the start of a complex signalling cascade, which ultimately mediates cellular activities such as proliferation, differentiat...

    Authors: Soha Salama El Sheikh, Jan Domin, Prakitpunthu Tomtitchong, Paul Abel, Gordon Stamp and El-Nasir Lalani

    Citation: BMC Clinical Pathology 2003 3:4

    Content type: Research article

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  19. In many animal models that investigate the pathology of various diseases, there is a need to monitor leukocyte counts and differentials. However, various researchers use a range of different techniques in male...

    Authors: Diana C Doeing, Jessica L Borowicz and Elahé T Crockett

    Citation: BMC Clinical Pathology 2003 3:3

    Content type: Research article

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  20. Over the past five years in situ hybridization techniques employing tyramide amplification reagents have been developed and promise the potential detection of low/single-copy nucleic acid sequences. However the i...

    Authors: Mark F Evans, Holly A Aliesky and Kumarasen Cooper

    Citation: BMC Clinical Pathology 2003 3:2

    Content type: Research article

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  21. Prostate cancer is one of the most frequent malignancies in males. Nevertheless, to this moment, there is no specific routine diagnostic marker to be used in clinical practice. Recently, the identification of ...

    Authors: Efstathios N Stathopoulos, Constantina Dambaki, Marilena Kampa, Panayiotis A Theodoropoulos, Ploutarchos Anezinis, Dimitrios Delakas, George S Delides and Elias Castanas

    Citation: BMC Clinical Pathology 2003 3:1

    Content type: Research article

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  22. Since it is impossible to sequence the complete CFTR gene routinely, clinical laboratories must rely on test systems that screen for a panel of the most frequent mutations causing disease in a high percentage ...

    Authors: Klaus Roland Huber, Borka Mirkovic, Rhea Nersesian, Angela Myers, Randall Saiki and Kurt Bauer

    Citation: BMC Clinical Pathology 2002 2:4

    Content type: Research article

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  23. Antioxidant molecules, which scavenge free radical species to prevent or delay oxidative damage of important macromolecules, membrane lipids and lipoproteins, are prevalent in plasma and other biological fluid...

    Authors: Marilena Kampa, Anastasia Nistikaki, Vassilios Tsaousis, Niki Maliaraki, George Notas and Elias Castanas

    Citation: BMC Clinical Pathology 2002 2:3

    Content type: Research article

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  24. Measurements of hormonal concentrations by immunoassays using fluorescent tracer substance (Eu3+) are susceptible to the action of chemical agents that may cause alterations in its original structure. Our goal...

    Authors: Maria Beatriz F Kohek, Cassia Regina M Leme, Izabel T Nakamura, Suzimara A de Oliveira, Valeria Lando and Berenice B Mendonca

    Citation: BMC Clinical Pathology 2002 2:2

    Content type: Research article

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  25. Herpes simplex keratitis is a sight threatening ocular infection. A rapid and specific diagnosis is essential for the institution of specific antiviral therapy and to avoid complications that can arise from mi...

    Authors: Sreedharan Athmanathan, Sesha Reddy Bandlapally and Gullapalli N Rao

    Citation: BMC Clinical Pathology 2002 2:1

    Content type: Research article

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  26. Reliability cannot be achieved in a clinical laboratory through the control of accuracy in the analytical phase of the testing process alone. Indeed a "mistake" can be defined as any defect occuring during the...

    Authors: Viroj Wiwanitkit

    Citation: BMC Clinical Pathology 2001 1:5

    Content type: Research article

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  27. Pelvic floor disorders affect almost 50% of aging women. An important role in the pelvic floor support belongs to the levator ani muscle. The p27/kip1 (p27) protein, multifunctional cyclin-dependent kinase inh...

    Authors: Antonin Bukovsky, Pleas Copas, Michael R Caudle, Maria Cekanova, Tamara Dassanayake, Bridgett Asbury, Stuart E Van Meter, Robert F Elder, Jeffrey B Brown and Stephanie B Cross

    Citation: BMC Clinical Pathology 2001 1:4

    Content type: Research article

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  28. Experimental colitis with features similar to inflammatory bowel disease (IBD) has initially been described. A detailed analysis of inflammatory cells has not yet been described. Therefore in this study we cha...

    Authors: Liljana Stevceva, Paul Pavli, Alan J Husband and William F Doe

    Citation: BMC Clinical Pathology 2001 1:3

    Content type: Research article

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  29. The association of insulin-dependent diabetes mellitus (IDDM) and celiac disease (CD) has been widely reported in children but the relationship between the two conditions is incompletely understood. Moreover, ...

    Authors: Marina Bertini, Andrea Sbarbati, Enrico Valletta, Leonardo Pinelli and Luciano Tatò

    Citation: BMC Clinical Pathology 2001 1:2

    Content type: Research article

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  30. Oxidative modification of low density lipoproteins (LDL) is recognized as one of the major processes involved in atherogenesis. The in vitro standardized measurement of LDL oxidative susceptibility could thus ...

    Authors: Adriana E Scoccia, María Silvina Molinuevo, Antonio Desmond McCarthy and Ana María Cortizo

    Citation: BMC Clinical Pathology 2001 1:1

    Content type: Methodology article

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