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Histopathology

Section edited by Rui Henrique

This section considers articles on all aspect of histopathology and includes articles investigating microscopic examinations of tissues from biopsies or surgical specimens, we encourage submission of studies on biomarkers.

  1. Studies on malignant melanoma have largely focused on Caucasian populations due to higher incidence in lighter-skinned individuals. While there is a well developed body of literature describing melanoma in Afr...

    Authors: Maurice Mulenga, Nathan D. Montgomery, Maganizo Chagomerana, Tenganawo Mzumala, Tamiwe Tomoka, Coxcilly Kampani, Yuri Fedoriw, Satish Gopal and Lisbet Sviland

    Citation: BMC Clinical Pathology 2019 19:5

    Content type: Research article

    Published on:

  2. The development of molecular techniques to estimate the risk of breast cancer recurrence has been a significant addition to the suite of tools available to pathologists and breast oncologists. It has previousl...

    Authors: Mark D. Zarella, Rebecca C. Heintzelman, Nikolay K. Popnikolov and Fernando U. Garcia

    Citation: BMC Clinical Pathology 2018 18:14

    Content type: Research article

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  3. Low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is distinctly rare. We report a patient with a uniquely biphasic LGNPPA; additionally, we review similar tumors reported in the literature.

    Authors: Hidenori Yokoi, Yuichi Terado, Masachika Fujiwara, Yuma Matsumoto, Tetsuya Ikeda and Koichiro Saito

    Citation: BMC Clinical Pathology 2018 18:10

    Content type: Case report

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  4. The identification of implant wear particles and non-implant related particles and the characterization of the inflammatory responses in the periprosthetic neo-synovial membrane, bone, and the synovial-like in...

    Authors: G. Perino, S. Sunitsch, M. Huber, D. Ramirez, J. Gallo, J. Vaculova, S. Natu, J. P. Kretzer, S. Müller, P. Thomas, M. Thomsen, M. G. Krukemeyer, H. Resch, T. Hügle, W. Waldstein, F. Böettner…

    Citation: BMC Clinical Pathology 2018 18:7

    Content type: Research article

    Published on:

  5. In lacrimal gland, lymphomas and inflammatory lesions predominate. Primary epithelial tumours represent less than 30% of lacrimal gland lesions. Myoepithelial carcinoma of lacrimal gland is rare. To the best o...

    Authors: Youssef Mahdi, Mohamed Amine Azami, Rajae Daoudi and Nadia Cherradi

    Citation: BMC Clinical Pathology 2018 18:6

    Content type: Case report

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  6. Primary hepatic neuroendocrine carcinoma (PHNEC) is extremely rare. The diagnosis of PHNEC remains challenging—partly due to its rarity, and partly due to its lack of unique clinical features. Available treatm...

    Authors: Zi-Ming Zhao, Jin Wang, Ugochukwu C. Ugwuowo, Liming Wang and Jeffrey P. Townsend

    Citation: BMC Clinical Pathology 2018 18:3

    Content type: Case report

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  7. Gastrointestinal stromal tumors (GIST) are the most common primary mesenchymal tumors of the digestive system. The assessment of their biological behavior still remains a scientific challenge. To date, there a...

    Authors: Boubacar Efared, Gabrielle Atsame-Ebang, Layla Tahiri, Ibrahim Sory Sidibé, Fatimazahra Erregad, Nawal Hammas, Samia Arifi, Ihsane Mellouki, Abdelmalek Ousadden, Khalid Mazaz, Hinde El Fatemi and Laila Chbani

    Citation: BMC Clinical Pathology 2018 18:2

    Content type: Research article

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  8. Endometrial cancer (EC) is a major health concern due to its rising incidence. Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis with limited treatment options. Altered...

    Authors: Ayşe Latif, Amy L. Chadwick, Sarah J. Kitson, Hannah J. Gregson, Vanitha N. Sivalingam, James Bolton, Rhona J. McVey, Stephen A. Roberts, Kay M. Marshall, Kaye J. Williams, Ian J. Stratford and Emma J. Crosbie

    Citation: BMC Clinical Pathology 2017 17:27

    Content type: Research article

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  9. Intraoperative consultation is an important tool for the evaluation of the upper aerodigestive tract (UAT) malignancies. Although frozen section analysis is a preferred method of intra-operative consultation, ...

    Authors: Hania Naveed, Mariam Abid, Atif Ali Hashmi, Muhammad Muzammamil Edhi, Ahmareen Khalid Sheikh, Ghazala Mudassir and Amir Khan

    Citation: BMC Clinical Pathology 2017 17:25

    Content type: Research article

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  10. Lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. It is extremely rare in the larynx and should be distinguished...

    Authors: Nawal Hammas, Najib Benmansour, Mohamed Nour-dine El Alami El Amine, Laila Chbani and Hind El Fatemi

    Citation: BMC Clinical Pathology 2017 17:24

    Content type: Case report

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  11. Medulloepithelioma is a rare primitive neuroectodermal tumor of the central nervous system, usually developing in childhood. Due to its rarity, the optimal management is still unknown. The prognosis is poor, e...

    Authors: Nezha Oumghar, Fatima Ezzahra Hazmiri, Abdelhamid El Omrani, Hanane Rais and Mouna Khouchani

    Citation: BMC Clinical Pathology 2017 17:23

    Content type: Case report

    Published on:

  12. Solitary fibrous tumor is an uncommon spindle cell neoplasm of unknown origin. It has been reported in many anatomic sites, with a rare occurrence in the head and neck region. Solitary fibrous tumors of the pa...

    Authors: Meryem Rais, Amine Kessab, Zahra Sayad, Sanae El Mourabit, Redallah Zrarqi, Salma Benazzou, Malik Boulaadas and Nadia Cherradi

    Citation: BMC Clinical Pathology 2017 17:22

    Content type: Case report

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  13. Primary hyperoxaluria is a rare disease with an estimated prevalence of 1 to 3 cases per million. It is due to a hepatic enzyme deficiency responsible for an endogenous overproduction of oxalate. Oxalate cryst...

    Authors: F. Nachite, M. Dref, A. Fakhri and H. Rais

    Citation: BMC Clinical Pathology 2017 17:20

    Content type: Case report

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  14. Mosquito coil (MC) emits insecticide upon burning which provides limited protection against lethal mosquito borne diseases. However, apart from killing the insect, toxicities associated with the inhalation of ...

    Authors: M. Abdulla Al-Mamun, M. Ataur Rahman, M. Habibur Rahman, K.M.F. Hoque, Z. Ferdousi, Mohammad Nurul Matin and M. Abu Reza

    Citation: BMC Clinical Pathology 2017 17:19

    Content type: Research article

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  15. Primary breast angiosarcoma is defined as malignant proliferation showing endothelial differentiation. It is a very rare tumour (0.05% of primary mammary cancers), whose diagnosis can be difficult.

    Authors: Fayçal Abbad, Najat Cherif Idrissi, Btissam Fatih, Bouchra Fakhir, Jamal Drissi, Mouna Khouchani and Hanane Rais

    Citation: BMC Clinical Pathology 2017 17:17

    Content type: Case report

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  16. Ovarian sarcomas represent less than 1% of all ovary cancers and usually are frequent in adults. Primary angiosarcomas are exceptional in the ovaries within children.

    Authors: Tchin Darré, Abdoul-Samadou Aboubakari, Bingo K. N’Bortche, Akila Bassowa, Solange Adani-Ifé and Gado Napo-Koura

    Citation: BMC Clinical Pathology 2017 17:16

    Content type: Case report

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  17. Malignant Deciduoid Mesothelioma (MDM) is an extremely rare variant of epithelioid mesothelioma. It was first described in young females, in the peritoneum, and its relation with asbestos was not well defined.

    Authors: Mouna Khmou, Soumiya Echcharif, Rachad Kabbaj and Basma El Khannoussi

    Citation: BMC Clinical Pathology 2017 17:13

    Content type: Case report

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  18. Inflammatory myofibroblastic tumour (IMT) is a mesenchymal neoplasm of intermediate biological potential that may affect a wide range of anatomic sites but has a particular predilection for the lung and intra-...

    Authors: Adil Boudhas, Mohamed Allaoui, Fouad El Asri, Issam Rharrassi, Mohamed Reda El Ochi, Mohamed Tbouda, Hafsa Chahdi, Abderrahmane Al Bouzidi and Mohamed Oukabli

    Citation: BMC Clinical Pathology 2017 17:12

    Content type: Case report

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  19. Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The pu...

    Authors: Stefan Haraldsson, Louise Klarskov, Mef Nilbert, Inge Bernstein, Jesper Bonde and Susanne Holck

    Citation: BMC Clinical Pathology 2017 17:11

    Content type: Research article

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  20. Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo. The case of a PDTC adjacent to a ...

    Authors: Hironao Yasuoka, Yasushi Nakamura, Mitsuyoshi Hirokawa, Ken-ichi Yoshida, Kana Anno, Masayuki Tori and Masahiko Tsujimoto

    Citation: BMC Clinical Pathology 2017 17:9

    Content type: Case report

    Published on:

  21. As the major subfamily of receptor tyrosine, erythropoietin-producing hepatocellular (Eph) receptor has been related to progression and prognosis in different types of tumors. However, the role and mechanism o...

    Authors: Baongoc Nasri, Mikito Inokuchi, Toshiaki Ishikawa, Hiroyuki Uetake, Yoko Takagi, Sho Otsuki, Kazuyuki Kojima and Tatsuyuki Kawano

    Citation: BMC Clinical Pathology 2017 17:8

    Content type: Research article

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  22. The coexistence of Rosai-Dorfman disease (RDD) with Langerhans cell histiocytosis (LCH) is very rare, as to date only 17 cases have been reported in the english literature. The pathophysiology of this uncommon...

    Authors: Boubacar Efared, Asmae Mazti, Badarou Chaibou, Gabrielle Atsame-Ebang, Ibrahim Sory Sidibé, Layla Tahiri, Fatimazahra Erregad, Nawal Hammas, Abdelmajid El Mrini, Hinde El Fatemi and Laila Chbani

    Citation: BMC Clinical Pathology 2017 17:5

    Content type: Case report

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  23. Urothelial bladder carcinoma (UBC) is one of the most prevalent cancers in men worldwide. Human epidermal growth factor receptor 2 (HER2) expression has been detected in a wide range of urothelial carcinoma. D...

    Authors: Mohamed Reda El Ochi, Mohamed Oukabli, Elarbi Bouaiti, Hafsa Chahdi, Adil Boudhas, Mohamed Allaoui, Ahmed Ameur, Mohamed Abbar and Abderrahmane Al Bouzidi

    Citation: BMC Clinical Pathology 2017 17:3

    Content type: Research article

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  24. Detection of vascular invasion by hematoxylin and eosin staining is the current pathological assessment practice to diagnose breast carcinoma. However, conventional hematoxylin and eosin staining failed to dis...

    Authors: Nur Fatiha Norhisham, Choi Yen Chong and Sabreena Safuan

    Citation: BMC Clinical Pathology 2017 17:2

    Content type: Research article

    Published on:

  25. Mycetoma is a chronic granulomatous infectious disease caused by filamentous bacteria or by fungi. The disease is endemic in certain tropical and subtropical areas of the world but can be found elsewhere posin...

    Authors: Boubacar Efared, Layla Tahiri, Marou Soumana Boubacar, Gabrielle Atsam-Ebang, Nawal Hammas, El Fatemi Hinde and Laila Chbani

    Citation: BMC Clinical Pathology 2017 17:1

    Content type: Case report

    Published on:

  26. Podocalyxin-like protein (PODXL) is a cell surface transmembrane glycoprotein, the expression of which has been associated with poor prognosis in a range of malignancies. The aim of this study was to investiga...

    Authors: David Borg, Charlotta Hedner, Björn Nodin, Anna Larsson, Anders Johnsson, Jakob Eberhard and Karin Jirström

    Citation: BMC Clinical Pathology 2016 16:13

    Content type: Research article

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  27. Calcifications of atherosclerotic plaques represent a controversial issue as they either lead to the stabilization or rupture of the lesion. However, the cellular key players involved in the progression of the...

    Authors: Silvia Fittipaldi, Francesco Vasuri, Alessio Degiovanni, Rodolfo Pini, Mauro Gargiulo, Andrea Stella, Gianandrea Pasquinelli, William G. Thilly and Elena V. Gostjeva

    Citation: BMC Clinical Pathology 2016 16:12

    Content type: Research article

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  28. Effective management of trauma-related invasive fungal wound infections (IFIs) depends on early diagnosis and timely initiation of treatment. We evaluated the utility of routine staining, histochemical stains ...

    Authors: Sarah M. Heaton, Amy C. Weintrob, Kevin Downing, Bryan Keenan, Deepak Aggarwal, Faraz Shaikh, David R. Tribble and Justin Wells

    Citation: BMC Clinical Pathology 2016 16:11

    Content type: Research article

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  29. Cellular angiofibroma represents a newly described, site specific tumor. Histologically, CAF is a benign mesenchymal neoplasm characterized by two principal components: bland spindle cells and prominent small ...

    Authors: Mouna Khmou, Najat Lamalmi, Abderrahmane Malihy, Lamia Rouas and Zaitouna Alhamany

    Citation: BMC Clinical Pathology 2016 16:8

    Content type: Case report

    Published on:

  30. In the spectrum of molecular alterations found in hepatocellular carcinoma (HCC), somatic mutations in the WNT/β-catenin pathway and the p53/cell cycle control pathway are among the most frequent ones. It has ...

    Authors: Juliane Friemel, Markus Rechsteiner, Marion Bawohl, Lukas Frick, Beat Müllhaupt, Mickaël Lesurtel and Achim Weber

    Citation: BMC Clinical Pathology 2016 16:7

    Content type: Case report

    Published on:

  31. Teratomas are a germ cell tumors composed of two or more tissues which originate from ectoderm, endoderm or mesoderm. These tumors commonly arise from the ovary although other extragonadal sites can be involve...

    Authors: Emmanuel Kamgobe, Anthony Massinde, Dismas Matovelo, Edgar Ndaboine, Peter Rambau and Tito Chaula

    Citation: BMC Clinical Pathology 2016 16:5

    Content type: Case report

    Published on:

  32. Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. They are malignant in 20 % of cases. Only a few cases of malignant phyllodes tumors metastatic to bone hav...

    Authors: Mohamed Reda El Ochi, Mehdi Toreis, Mohamed Benchekroun, Zineb Benkerroum, Mohamed Allaoui, Mohamed Ichou, Basma El Khannoussi, Abderrahman Albouzidi and Mohamed Oukabli

    Citation: BMC Clinical Pathology 2016 16:4

    Content type: Case report

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  33. Adverse local tissue reaction (ALTR), characterized by a heterogeneous cellular inflammatory infiltrate and the presence of corrosion products in the periprosthetic soft tissues, has been recognized as a mecha...

    Authors: Benjamin F. Ricciardi, Allina A. Nocon, Seth A. Jerabek, Gabrielle Wilner, Elianna Kaplowitz, Steven R. Goldring, P. Edward Purdue and Giorgio Perino

    Citation: BMC Clinical Pathology 2016 16:3

    Content type: Research article

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  34. Leiomyosarcoma is a rare malignant mesenchymal tumor that represents 5–7 % of all soft tissue sarcomas. The occurrence of this tumor in the salivary glands is exceptional. Only five cases are reported in the s...

    Authors: Mohamed Reda El Ochi, Hafsa Chahdi, Issam Rharrassi, Abderrahman Albouzidi and Mohamed Oukabli

    Citation: BMC Clinical Pathology 2015 15:22

    Content type: Case report

    Published on:

  35. Adenocarcinoma of the periampullary region is associated with poor prognosis and new prognostic and treatment predictive biomarkers are needed for improved treatment. Membranous expression of podocalyxin-like ...

    Authors: Margareta Heby, Jakob Elebro, Björn Nodin, Karin Jirström and Jakob Eberhard

    Citation: BMC Clinical Pathology 2015 15:10

    Content type: Research article

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  36. The mevalonate pathway synthetizes cholesterol, steroid hormones, and non-steriod isoprenoids necessary for cell survival. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is the rate-limiting enzyme of...

    Authors: Emma Gustbée, Helga Tryggvadottir, Andrea Markkula, Maria Simonsson, Björn Nodin, Karin Jirström, Carsten Rose, Christian Ingvar, Signe Borgquist and Helena Jernström

    Citation: BMC Clinical Pathology 2015 15:8

    Content type: Research article

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  37. Individually submitted prostatic needle biopsies are recommended by most guidelines because of their potential advantage in terms of core quality. However, unspecified bilateral biopsies are commonly submitted...

    Authors: Teemu T Tolonen, Jorma Isola, Antti Kaipia, Jarno Riikonen, Laura Koivusalo, Sanna Huovinen, Marita Laurila, Sinikka Porre, Mika Tirkkonen and Paula Kujala

    Citation: BMC Clinical Pathology 2015 15:4

    Content type: Research article

    Published on:

  38. Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme in lung, gastric, col...

    Authors: Lara Termini, José H Fregnani, Enrique Boccardo, Walter H da Costa, Adhemar Longatto-Filho, Maria A Andreoli, Maria C Costa, Ademar Lopes, Isabela W da Cunha, Fernando A Soares, Luisa L Villa and Gustavo C Guimarães

    Citation: BMC Clinical Pathology 2015 15:3

    Content type: Research article

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