Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population

BMC Clinical Pathology

Table 1 Reference intervals for serum cystatin C and serum creatinine according to sex

Parameter	All (n = 381)	Males (n = 194)	Females (n = 187)	p*
Age (years)	28 [23–40]	28 [24–40]	26 [22–43]	0.290
BSA (m²)	1.68 [1.55–1.79]	1.70 [1.81]	1.65 [1.52–1.76]	0.002^*
Serum cystatin C (mg/L)
Median [IQR]	0.80 [0.70–0.90]	0.90 [0.80–1.00]	0.80 [0.70–0.90]	< 0.001
2.5th percentile (90%CI)	0.60 (0.60–0.61)	0.70 (0.60–0.70)	0.57 (0.50–0.60)
97.5th percentile (90%CI)	1.10 (1.10–1.11)	1.10 (1.10–1.20)	1.03 (1.00–1.10)
Serum creatinine (mg/dL)
Median [IQR]	0.92 [0.77–1.06]	1.06 [0.96–1.14]	0.79 [0.71–0.88]	< 0.001
2.5th percentile (90% CI)	0.61 (0.59–0.64)	0.74 (0.70–0.80)	0.58 (0.54–0.61)
97.5th percentile (90% CI)	1.30 (1.28–1.35)	1.36 (1.30–1.45)	1.08 (1.02–1.21)

BSA body surface area, CI confidence interval, IQR interquartile range, SCysC serum cystatin C, SCr serum creatinine; ^†The Mann-Whitney U-test was used for variable comparisons; ^*p < 0.05

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