Fig. 1

Transformation of staining attributes. a The ER and PR percent positive cells metric was transformed to a diagnostic score using logistic transformation. As indicated by the dotted lines, the curve is half maximum at the diagnostic cut-off of 10%, producing a score of 0.5. Gray points indicate the relationship between H-score and percent positive cells using simulations. b The logistic transformation is applied to the Ki-67% positive cells metric using a diagnostic cut-off of 14% to produce a diagnostic score. c Her2 score is transformed to a diagnostic score by dividing its value by 3, maintaining a linear relationship