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Fig. 9 | BMC Clinical Pathology

Fig. 9

From: Diagnostic guidelines for the histological particle algorithm in the periprosthetic neo-synovial tissue

Fig. 9

Differential diagnosis between particle laden macrophagic infiltrate and other macrophagic diseases in bone. a Implant aseptic loosening (osteolysis). Dense macrophage infiltrate in the bone marrow in a MoP THA implant (H&E × 200) containing birefringent PE microparticles under polarized light in inset (× 400). b Implant aseptic loosening (osteolysis). Diffuse, brownish macrophage infiltrate containing tribocorrosion and conventional metallic particles in a femoral head of a MoM HRA implant (H&E × 200). c Gaucher’s disease. Macrophage infiltrate in the bone marrow of a femoral head (H&E × 200) with details of the macrophage crumpled cytoplasm in inset (H&E × 400). d Erdheim-Chester disease. Bone marrow from proximal tibia with foamy macrophages and mixed chronic inflammatory infiltrate (H&E × 200) and mixed chronic inflammatory infiltrate and adjacent sclerotic cancellous bone with osteoblastic rimming in inset (H&E × 400)

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BMC Clinical Pathology

ISSN: 1472-6890

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