Fig. 2

Representative examples of MCT1, MCT4 and CD147 distribution and subcellular localization in EC tumours. a MCT1 and b MCT4 were found to dominate different zones of the same tumour, peripheral and central zones, respectively. c CD147 expression was observed in the same zone with MCT1. In some, strong glandular staining for d MCT1 and g MCT4 was observed with no stromal staining. In others, stromal expression of e MCT1 and h MCT4 were higher than glandular staining. Some tumours showed similar levels of f MCT1 and i MCT4 expression in both glandular and stromal tumour compartments. In more than half of the tumours, nuclear MCT1 staining (j and k) was observed. Arrows indicate stromal compartment between malignant glands. Scale bars represent 500 μm, 100 μm and 50 μm in (a-c), (d-i) and (j-k), respectively