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Table 1 Comparison of Hematologic and Morphologic Features Between Early and Late Relapse Patients

From: Impending relapse of myelodysplastic syndrome after allogeneic transplant is difficult to diagnose and requires a multi-modal approach

  Early Relapse (<6 months)
n = 10
Late Relapse (>6 months)
n = 11
p-value
Age at transplant, years, median (range) 67 (34–71) 58 (46–61) 0.013
Gender, M:F 5:5 6:5 NS
Time to relapse from transplant, months, median (range) 3 (2–6) 15 (6–82) <0.001
Pre-transplant MDS specimen, peripheral blood and bone marrow characteristics
 Hgb, g/dL, median(range) 9.0 (7.6–12.7) 9.3 (5.6–12.9) NS
 MCV, fL, median (range) 89 (73–109) 101 (86–107) 0.023
 WBC, × 109/L, median (range) 3.0 (1.1–10.2) 3.3 (1–33) NS
 ANC, × 109/L, median (range) 0.9 (0.1–7.8) 1.1 (0.4–24.1) NS
 Platelets, × 109/L, median (range) 36 (10–1242) 89 (5–206) NS
 Blood blasts, %, median (range) 1 (0–16) 0.5 (0–13) NS
 Dysgranulopoiesisa 4/7 3/8 NS
 Dyserythropoeisisa 5/7 6/8 NS
 Dysmegakaryopoiesisa 4/6 5/3 NS
 Ring sideroblastsa 4/8 4/9 NS
 Marrow cellularity, %, median (range) 90 (15–95) 43 (30–95) 0.075
 Bone marrow blasts, %, median (range) 4 (1–19) 7 (2–14) NS
 Increased marrow blasts (>5%) 7/10 (70%) 8/11 (72%) NS
Relapse myeloid neoplasm specimen, peripheral blood and bone marrow characteristics
 Hgb, g/dL, median(range) 10.0 (8.6–12.2) 9.8 (8.1–13) NS
 MCV, fL, median (range) 88 (80–105) 99 (87–113) 0.051
 WBC, × 109/L, median (range) 2.2 (0.6–7.6) 2.5 (1.5–3.4) NS
 ANC, × 109/L, median (range) 1.3 (0.2–5.9) 1.2 (0.2–2.5) NS
 Platelets, × 109/L, median (range) 20 (7–128) 66 (10–189) 0.061
 Blood blasts, %, median (range) 0.3 (0–15) 2 (0–38) NS
 Dysgranulopoiesisa 3/9 2/11 NS
 Dyserythropoeisisa 5/9 6/11 NS
 Dysmegakaryopoiesisa 7/8:5/8 6/10:3/10 NS
 Ring sideroblastsa 6/6 1/3 0.033
 Marrow cellularity, %, median (range) 48 (20–90) 45 (10–90) NS
 Bone marrow blasts, %, median (range) 5 (0.2–30) 14 (4–51) 0.029
 Increased marrow blasts (>5%) 5/10 (50%) 10/11 (91%) 0.063
  1. Bold indicates statistical significance
  2. aAny degree of dysplasia ≥10% of a lineage. See text (materials and methods section) for specific dysplastic features included for this study; “n” for dysplasia and ring sideroblast evaluation varies for each category depending on the slides and number of precursors in each lineage available for review
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