Table 1 Comparison of Hematologic and Morphologic Features Between Early and Late Relapse Patients

Age at transplant, years, median (range)

67 (34–71)

58 (46–61)

0.013

Gender, M:F

5:5

6:5

NS

Time to relapse from transplant, months, median (range)

3 (2–6)

15 (6–82)

<0.001

 Hgb, g/dL, median(range)

9.0 (7.6–12.7)

9.3 (5.6–12.9)

NS

 MCV, fL, median (range)

89 (73–109)

101 (86–107)

0.023

 WBC, × 10⁹/L, median (range)

3.0 (1.1–10.2)

3.3 (1–33)

NS

 ANC, × 10⁹/L, median (range)

0.9 (0.1–7.8)

1.1 (0.4–24.1)

NS

 Platelets, × 10⁹/L, median (range)

36 (10–1242)

89 (5–206)

NS

 Blood blasts, %, median (range)

1 (0–16)

0.5 (0–13)

NS

 Dysgranulopoiesis^a

4/7

3/8

NS

 Dyserythropoeisis^a

5/7

6/8

NS

 Dysmegakaryopoiesis^a

4/6

5/3

NS

 Ring sideroblasts^a

4/8

4/9

NS

 Marrow cellularity, %, median (range)

90 (15–95)

43 (30–95)

0.075

 Bone marrow blasts, %, median (range)

4 (1–19)

7 (2–14)

NS

 Increased marrow blasts (>5%)

7/10 (70%)

8/11 (72%)

NS

 Hgb, g/dL, median(range)

10.0 (8.6–12.2)

9.8 (8.1–13)

NS

 MCV, fL, median (range)

88 (80–105)

99 (87–113)

0.051

 WBC, × 10⁹/L, median (range)

2.2 (0.6–7.6)

2.5 (1.5–3.4)

NS

 ANC, × 10⁹/L, median (range)

1.3 (0.2–5.9)

1.2 (0.2–2.5)

NS

 Platelets, × 10⁹/L, median (range)

20 (7–128)

66 (10–189)

0.061

 Blood blasts, %, median (range)

0.3 (0–15)

2 (0–38)

NS

 Dysgranulopoiesis^a

3/9

2/11

NS

 Dyserythropoeisis^a

5/9

6/11

NS

 Dysmegakaryopoiesis^a

7/8:5/8

6/10:3/10

NS

 Ring sideroblasts^a

6/6

1/3

0.033

 Marrow cellularity, %, median (range)

48 (20–90)

45 (10–90)

NS

 Bone marrow blasts, %, median (range)

5 (0.2–30)

14 (4–51)

0.029

 Increased marrow blasts (>5%)

5/10 (50%)

10/11 (91%)

0.063