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Table 6 True positive, true negative, sensitivity and specificity for CIN2+ in different studies using ASC-US+ as cut-off

From: Accuracy of cervical cytology: comparison of diagnoses of 100 Pap smears read by four pathologists at three hospitals in Norway

Study TP TN FP FN SE (%) SP (%) AU (%) PPV (%) NPV (%)
Katki 2011 [10] 1 226 318 093 11 415 1 084 53.12 96.51 78.41 9.72 99.71
Dillner 2008 [15] 242 22 883 1 031 139 63.51 95.72 79.61 19.01 99.42
Castle 2012 [16] 136 18 190 926 260 34.32 95.22 64.72 12.81 98.61
Szarewski 2008 [17] 256 236 444 17 93.81 34.72 64.22 36.61 93.32
Sørbye 2011 [18] 48 92 77 8 85.71 54.42 70.12 38.41 92.02
Total 1 908 359 494 13 893 1 508 55.9 96.3 76.1 12.1 99.6
  1. TP true positive, TN true negative, FP false positive, FN false negative, SE sensitivity, SP specificity, AU = AUROC = accuracy = (SE+SP)/2, PPV positive predictive value, NPV negative predictive value, ASC-US+ = ASC-US, LSIL, ASC-H and HSIL, CIN2+ = CIN2, CIN3 and cancer
  2. 1Significantly higher than the average (p<0.05)
  3. 2Significantly lower than the average (p<0.05)