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Table 1 Patients with systemic meningococcal disease and their clinical characteristics

From: Traceability and distribution of Neisseria meningitidis DNA in archived post mortem tissue samples from patients with systemic meningococcal disease

Patient No
Serogroup
Neisserial DNA; copy number of N.meningitidis/mL
LPS (LAL); EU/mL at admission to hospital* not available
Age of tissue at isolation time of DNA (years) Type of storage methods Type of organ tissue Findings at autopsy # no obviously pathological changes
1
Serogroup B
2.8x108copies/mL (plasma)
2100 EU/mL (plasma)
No spinal puncture was performed
11 FFPE Skin
Adrenal glands
Lungs
Heart
Liver
Kidneys
Spleen
Brain
Skin hemorrhages
Hemorrhage
Edema
Petechiae on epicard and endocard
#
Dark-red congested medulla and pale cortex (shock kidneys). Fibrin thrombi in glomeruli.
#
Fibrin thrombi in vessels in choroid plexus
2
Serogroup B
3.8x107copies/mL (plasma)
271 EU/mL (plasma)
No spinal puncture was performed
10 FFPE Skin
Adrenal glands
Lungs
Heart
Liver
Kidneys
Spleen
Brain
Skin hemorrhages
Hemorrhage
An localized area with atelectasis, some neutrophils and small hemorrhages. Fibrin thrombi in vessels.
Petechiae on epicard
#
Congested vessels in medulla and fibrin thrombi in glomeruli
#
Fibrin thrombi in some vessels
3
Serogroup B
most likely
1.0x108copies/mL (serum)
2140 EU/mL (serum)
Spinal puncture was performed post mortem.
CSF contained 8 EU/mL
5
5
FFPE
FF
Skin
Adrenal glands
Lungs
Heart
Liver
Kidneys
Spleen
Brain
Skin hemorrhages
Hemorrhage
#
Petechiae on epicard
#
Dark-red congested medulla and pale cortex (shock kidneys)
#
#
4
Serogroup C
3.0x107copies/mL (serum)
3800 EU/mL (serum)
No spinal puncture was performed
2
2
FFPE
FF
Skin
Adrenal glands
Lungs
Heart
Liver
Kidneys
Spleen
Brain
Skin hemorrhages
Hemorrhage
Congestion
Petechiae on epicard. Microabscess in myocard
#
Congested vessels in medulla and multiple fibrin thrombi in glomeruli
#
#
5
Serogroup C
*
*
*
6
6
FFPE
FF
Skin
Adrenal glands
Lungs
Heart
Liver
Kidneys
Spleen
Brain
Skin hemorrhages
Hemorrhage
#
#
#
#
#
#
6
Serogroup B
0.25 EU/mL (plasma)
*
28 FFPE Lungs
Heart
Liver
Kidneys
Spleen
Brain
Edema
#
#
#
#
Edema, herniation of cerebellum, pus in meninges
7
Serogroup B
1.1x105copies/mL (plasma)
2.1 EU/mL (plasma)
4000 EU/mL (CSF)
28 FFPE Lungs
Kidneys
Brain
Edema
#
Edema, herniation of cerebellum, pus in meninges