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Table 2 Association of lymphatic vessel density with clinical criteria

From: Peritumoral lymphatic vessel density and invasion detected with immunohistochemical marker D240 is strongly associated with distant metastasis in breast carcinoma

  

Total LVD

Intra-tumoral LVD

Peri-tumoural LVD

Low

High

p-value

Low

High

p-value

Low

High

p-value

Age

<40

0 (0.0)

4 (13.3)

0.020

2 (7.4)

2 (6.9)

0.941

0 (0.0)

4 (13.8)

0.017

≥40

27 (100.0)

26 (86.7)

25 (92.6)

27 (93.1)

28 (100.0)

2 (86.2)

Tumor size

<30

2 (7.7)

9 (31.0)

0.080

3 (11.1)

8 (28.6)

0.255

3 (11.1)

8 (28.6)

0.255

30 ≤ × < 60

15 (57.7)

12 (41.4)

15 (55.6)

12 (42.9)

15 (55.6)

12 (42.9)

60 ≥

9 (34.6)

8 (27.6)

9 (33.3)

8 (28.6)

9 (33.3)

8 (28.6)

Grade

I

2 (7.7)

8 (26.7)

0.018

1 (3.7)

9 (31.0)

0.030

13 (11.1)

7 (24.1)

0.079

II

13 (50.0)

14 (46.7)

15 (55.6)

12 (41.4)

14 (51.9)

13 (44.8)

III

11 (42.3)

5 (16.7)

10 (37.0)

6 (20.7)

10 (37.0)

6 (20.7)

No grade

0

3 (10.0)

1 (3.7)

2 (6.9)

0

3 (10.3)

Distant metastasis

Yes

7 (25.9)

8 (27.6)

0.989

8 (29.6)

7 (23.3)

0.065

7 (25.0)

8 (27.6)

0.049

No

18 (66.7)

19 (65.5)

19 (70.4)

19 (63.3)

21 (75.0)

17 (58.6)

Not determine

2 (7.4)

2 (6.9)

0

4 (13.3)

0

4 (13.8)

Recurrence

No

26 (96.3)

29 (96.7)

0.940

27 (100)

27 (93.1)

0.1

27 (96.4)

28 (96.6)

0.980

Yes

1 (3.7)

1 (3.3)

0

2 (6.9)

1 (3.6)

1 (3.4)

ER

Positive

16 (61.5)

16 (55.2)

0.632

16 (61.5)

15 (53.6)

0.554

17 (63.0)

15 (53.6)

0.480

Negative

10 (38.5)

13 (44.8)

10 (38.5)

13 (46.4)

10 (37.0)

13 (46.4)

PR

Positive

15 (55.6)

13 (44.8)

0.422

13 (48.1)

14 (50.0)

0.891

16 (57.1)

12 (42.9)

0.284

Negative

12 (44.4)

16 (55.2)

14 (51.9)

14 (50.0)

12 (42.9)

16 (57.1)

Lymph nodes involvement

0

8 (29.6)

11 (37.9)

0.374

8 (30.8)

11 (37.9)

0.678

7 (25.0)

12 (42.9)

0.266

1

3 (11.1)

3 (10.3)

3 (11.5)

3 (10.3)

4 (14.3)

2 (7.1)

2 to 4

6 (22.2)

10 (34.5)

6 (23.1)

10 (31.0)

7 (25)

9 (32.1)

>4

10 (37.0)

5 (17.2)

9 (34.6)

6 (20.7)

10 (35.7)

5 (17.9)

  1. *Bold datas refer to statistically significant association (p<0.05)