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Table 2 Association of lymphatic vessel density with clinical criteria

From: Peritumoral lymphatic vessel density and invasion detected with immunohistochemical marker D240 is strongly associated with distant metastasis in breast carcinoma

   Total LVD Intra-tumoral LVD Peri-tumoural LVD
Low High p-value Low High p-value Low High p-value
Age <40 0 (0.0) 4 (13.3) 0.020 2 (7.4) 2 (6.9) 0.941 0 (0.0) 4 (13.8) 0.017
≥40 27 (100.0) 26 (86.7) 25 (92.6) 27 (93.1) 28 (100.0) 2 (86.2)
Tumor size <30 2 (7.7) 9 (31.0) 0.080 3 (11.1) 8 (28.6) 0.255 3 (11.1) 8 (28.6) 0.255
30 ≤ × < 60 15 (57.7) 12 (41.4) 15 (55.6) 12 (42.9) 15 (55.6) 12 (42.9)
60 ≥ 9 (34.6) 8 (27.6) 9 (33.3) 8 (28.6) 9 (33.3) 8 (28.6)
Grade I 2 (7.7) 8 (26.7) 0.018 1 (3.7) 9 (31.0) 0.030 13 (11.1) 7 (24.1) 0.079
II 13 (50.0) 14 (46.7) 15 (55.6) 12 (41.4) 14 (51.9) 13 (44.8)
III 11 (42.3) 5 (16.7) 10 (37.0) 6 (20.7) 10 (37.0) 6 (20.7)
No grade 0 3 (10.0) 1 (3.7) 2 (6.9) 0 3 (10.3)
Distant metastasis Yes 7 (25.9) 8 (27.6) 0.989 8 (29.6) 7 (23.3) 0.065 7 (25.0) 8 (27.6) 0.049
No 18 (66.7) 19 (65.5) 19 (70.4) 19 (63.3) 21 (75.0) 17 (58.6)
Not determine 2 (7.4) 2 (6.9) 0 4 (13.3) 0 4 (13.8)
Recurrence No 26 (96.3) 29 (96.7) 0.940 27 (100) 27 (93.1) 0.1 27 (96.4) 28 (96.6) 0.980
Yes 1 (3.7) 1 (3.3) 0 2 (6.9) 1 (3.6) 1 (3.4)
ER Positive 16 (61.5) 16 (55.2) 0.632 16 (61.5) 15 (53.6) 0.554 17 (63.0) 15 (53.6) 0.480
Negative 10 (38.5) 13 (44.8) 10 (38.5) 13 (46.4) 10 (37.0) 13 (46.4)
PR Positive 15 (55.6) 13 (44.8) 0.422 13 (48.1) 14 (50.0) 0.891 16 (57.1) 12 (42.9) 0.284
Negative 12 (44.4) 16 (55.2) 14 (51.9) 14 (50.0) 12 (42.9) 16 (57.1)
Lymph nodes involvement 0 8 (29.6) 11 (37.9) 0.374 8 (30.8) 11 (37.9) 0.678 7 (25.0) 12 (42.9) 0.266
1 3 (11.1) 3 (10.3) 3 (11.5) 3 (10.3) 4 (14.3) 2 (7.1)
2 to 4 6 (22.2) 10 (34.5) 6 (23.1) 10 (31.0) 7 (25) 9 (32.1)
>4 10 (37.0) 5 (17.2) 9 (34.6) 6 (20.7) 10 (35.7) 5 (17.9)
  1. *Bold datas refer to statistically significant association (p<0.05)
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