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Table 2 Hazard ratios for recurrence and death (M0, R0-1)

From: Expression of podocalyxin-like protein is an independent prognostic biomarker in resected esophageal and gastric adenocarcinoma

  Time to recurrence Overall survival
  Unadjusted Adjusted   Unadjusted Adjusted
n (events) HR (95 % CI) p-value HR (95 % CI) p-value n (events) HR (95 % CI) p-value HR (95 % CI) p-value
Age
 Continuous 136 (72) 1.00 (0.98–1.02) 0.610    151 (104) 1.04 (1.02–1.06) <0.001 1.05 (1.03–1.07) <0.001
Sex
 Female 27 (12)      30 (22)     
 Male 109 (60) 1.18 (0.63–2.19) 0.610    121 (82) 0.81 (0.50–1.29) 0.370
T stage    <0.001   0.043    0.010   0.511
 T1 18 (3)      19 (7)     
 T2 27 (8) 2.14 (0.57–8.06) 0.263 1.53 (0.39–5.96) 0.538 30 (19) 2.09 (0.88–4.97) 0.097 1.53 (0.62–3.78) 0.357
 T3 77 (51) 6.92 (2.15–22.29) 0.001 3.72 (1.10–12.64) 0.035 86 (66) 3.27 (1.49–7.15) 0.003 1.79 (0.79–4.08) 0.164
 T4 14 (10) 8.52 (2.33–31.16) 0.001 3.52 (0.92–13.56) 0.067 16 (12) 3.71 (1.45–9.48) 0.006 1.98 (0.74–5.31) 0.175
N stage
 N0 50 (7)      53 (26)     
 N1-3 86 (65) 9.89 (4.51–21.72) <0.001 7.78 (3.24–18.71) <0.001 98 (78) 2.56 (1.63–4.00) <0.001 2.79 (1.67–4.66) <0.001
R classification
 R0 103 (46)      113 (69)     
 R1 33 (26) 2.89 (1.76–4.74) <0.001 1.38 (0.79–2.41) 0.253 38 (35) 2.75 (1.80–4.20) <0.001 2.07 (1.29–3.31) 0.003
Differentiation grade
 Low/Intermediate grade 49 (18)      56 (31)     
 High grade 87 (54) 2.22 (1.30–3.79) 0.004 1.93 (1.09–3.42) 0.025 95 (73) 1.73 (1.13–2.63) 0.011 1.40 (0.88–2.20) 0.153
Lauren classification
 Intestinal 94 (45)      106 (69)     
 Diffuse/Mixed 42 (27) 1.57 (0.97–2.53) 0.064    45 (35) 1.35 (0.90–2.03) 0.149
Adjuvant treatment
 No 126 (63)      138 (94)     
 Chemo-/radiotherapy 10 (9) 2.12 (1.05–4.28) 0.036 0.96 (0.45–2.06) 0.924 13 (10) 1.20 (0.62–2.30) 0.589
Location
 Esophagus + EG junction 86 (49)      99 (69)     
 Stomach 50 (23) 0.74 (0.45–1.22) 0.239    52 (35) 0.90 (0.60–1.34) 0.592
PODXL expression
 Negative 20 (3)      24 (10)     
 Positive 113 (67) 5.36 (1.68–17.06) 0.005 3.39 (1.01–11.35) 0.048 124 (92) 2.52 (1.31–4.85) 0.006 2.03 (1.04–3.98) 0.039
  1. R0 = no residual tumor (free resection margins according to pathology report), R1 = possible microscopic residual tumor (narrow or compromised resection margins according to pathology report)