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Table 1 Associations of PODXL expression with clinicopathological factors

From: Expression of podocalyxin-like protein is an independent prognostic biomarker in resected esophageal and gastric adenocarcinoma

 

Entire cohort

PODXL neg

PODXL pos

 

n (%)

n (%)

n (%)

p-value

 

171 (100.0)

29 (17.0)

142 (83.0)

 

Age

 ≤70

85 (49.7)

12 (41.4)

73 (51.4)

0.416

 >70

86 (50.3)

17 (58.6)

69 (48.6)

Sex

 Female

39 (22.8)

9 (31.0)

30 (21.1)

0.330

 Male

132 (77.2)

20 (69.0)

112 (78.9)

T stage

 T1

18 (10.5)

2 (6.9)

16 (11.3)

0.637

 T2

32 (18.7)

6 (20.7)

26 (18.3)

 T3

94 (55.0)

16 (55.2)

78 (54.9)

 T4

27 (15.8)

5 (17.2)

22 (15.5)

N stage

 N0

57 (33.3)

16 (55.2)

41 (28.9)

0.006

 N1

29 (17.0)

4 (13.8)

25 (17.6)

 N2

41 (24.0)

6 (20.7)

35 (24.6)

 N3

44 (25.7)

3 (10.3)

41 (28.9)

M stage

 M0

152 (88.9)

25 (86.2)

127 (89.4)

0.535

 M1

19 (11.1)

4 (13.8)

15 (10.6)

R classification

 R0

117 (68.4)

22 (75.9)

95 (66.9)

0.556

 R1

45 (26.3)

5 (17.2)

40 (28.2)

 R2

9 (5.3)

2 (6.9)

7 (4.9)

Differentiation grade

 Low grade

8 (4.7)

4 (13.8)

4 (2.8)

0.023

 Intermediate grade

52 (30.4)

10 (34.5)

42 (29.6)

 High grade

111 (64.9)

15 (51.7)

96 (67.6)

Lauren classification

 Intestinal

119 (69.6)

23 (79.3)

96 (67.6)

0.335

 Mixed

9 (5.3)

0 (0.0)

9 (6.3)

 Diffuse

43 (25.1)

6 (20.7)

37 (26.1)

Location

 Esophagus + EG junction

106 (62.0)

15 (51.7)

91 (64.1)

0.217

 Stomach

65 (38.0)

14 (48.3)

51 (35.9)

  1. R0 = no residual tumor (free resection margins according to pathology report), R1 = possible microscopic residual tumor (narrow or compromised resection margins according to pathology report), R2 = macroscopic residual tumor (according to surgery report)
  2. N1 = metastasis in 1–2 regional lymph nodes, N2 = metastasis in 3–6 regional lymph nodes, N3 = metastasis in 7 or more regional lymph nodes
  3. The dichotomized variable for age is based on the mean/median age, as shown in Additional file 1