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Table 1 Morphology, immunohistochemistry and mutational status of individual tumor areas

From: Liver cancer with concomitant TP53 and CTNNB1 mutations: a case report

  Area A1 A2 A3 B C1 C2 C3 C4 C5 C6 C7 C8 C9 C10
  Size in mm2 7.8 5.54 31.3 65 73.2 16.5 34.5 82.2 20.2 18.9 17.4 28.5 1.94 17.5
Morphology Solid + + +   + + +   + +   +   
Glandular (cholangiocellular)     +           
Trabecular        + +    +   + +
Clear cell change   +    +          +
Fatty change            +    
  CK19     >50 %   >50 %         
IC CK7     70 % SC 50 % 20 % SC 40 % SC   SC   50 %
glutamine synthetase + + +            
β-catenin nuclear + + +            
p53 + + +            
Mutation CTNNB1 sanger seq D32 D32 wt wt wt wt wt wt wt wt wt wt wt wt
CTNNB1 deep seq D32 D32 D32a wt wt wt wt wt wt wt wt wt wt wt
TP53 sanger seq IVS8-1 IVS8-1 wt wt wt wt wt wt wt wt wt wt wt wt
TP53 deep seq IVS8-1 IVS8-1 IVS8-1a wt wt wt wt wt wt wt wt wt wt wt
  1. sanger seq sanger sequencing, deep seq deep sequencing (NGS), wt wild type, SC single cells positive
  2. alow frequency (<10 %)