Skip to main content

Table 6 Significant differences in histological findings from all three implant classes and the control group

From: Histopathological characterization of corrosion product associated adverse local tissue reaction in hip implants: a study of 285 cases

 

Non-MoM DMNTHA (N = 123 hips)

MoM HRA (N = 44 hips)

MoM LHTHA (N = 118 hips)

MoP OLTHA (N = 31 hips)

Synovial Structure

    

Synovial Layer Loss (%)

99

89

99

16.1

Soft Tissue Necrosis (%)

53‡

11‡

32‡

0‡

Sarcoid-like Granulomas (%)

16*

0*

5*

0

Campbell Score (median)

8§

5§

6§

-

Cellularity

    

Macrophages (% Grade 1, Grade 2, Grade 3)

7, 51, 42^

0, 5, 95^

1, 34, 65^

3, 16, 81^

Lymphocytes (% Grade 1, Grade 2, Grade 3, Grade 4)

7, 29, 34, 24°

25, 18, 11, 7 °

25, 31, 23, 10°

10, 0, 0, 0°

Plasma Cells (% Grade 1, Grade 2)

26, 18

11, 9

29, 18

0, 0

Eosinophils (%)

20

9

17

0

Macrophage Content

    

Polyethylene Particles (%)

2

0

0

80

Metallic Particles (%)

8#

39#

30#

65#

Corrosion Products (%)

95

100

99

0

Large Aggregates

74¶

11¶

63¶

0¶

Bone and Bone Marrow

N = 58

N = 44

N = 36

N = 0

Necrosis (%)

47

11

23

-

Macrophage Infiltration (%)

57

67

73

-

Germinal Centers (%)

12

2

3

-

Osteolysis (# cases)

4

9

4

-

  1. All values for synovial structure, macrophage content, eosinophils, cell distributions, and bone and bone marrow content expressed as percentage of cases with each morphologic feature
  2. *p = 0.013 for Non-MoM DMNTHA versus MoM LHTHA and MoM HRA
  3. ^p = 0.007 for OL versus Non-MoM DMNTHA; p = 0.007 for MoM HRA versus MoM LHTHA; MoM HRA versus Non-MoM DMNTHA, and Non-MoM DMNTHA versus MoM LHTHA
  4. °p = 0.007 for significant difference in distributions of lymphocyte grade between all implant classes except MoM LHTHA versus MoM HRA (p = 0.0023)
  5. # p = 0.007 for OL versus MoM LTHA and Non-MoM DMNTHA; p = 0.007 for Non-MoM DMNTHA versus MoM HRA and MoM LHTHA
  6. § p < 0.001 for significant difference in Campbell score between ALTR implant classes
  7. ‡p = 0.007 for OL versus Non-MoM DMNTHA, MoM LHTHA; p = 0.007 for MoM HRA versus Non-MoM DMNTHA; p = 0.009 MoM HRA versus MoM LHTHA; p = 0.0048 MoM LHTHA versus Non-MoM DMNTHA
  8. ¶p = 0.011 for OL versus MoM HRA; p = 0.007 OL versus Non-MoM DMNTHA and MoM LHTHA; p = 0.007 for MoM HRA versus MoM LHTHA and Non-MoM DMNTHA; p = 0.026 MoM LHTHA versus Non-MoM DMNTHA