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Table 3 Association of TAP and other clinical variables with outcome using Cox proportional hazard regression. TAP, chemotherapy, grade, stage and age are shown as individual and multivariable models. Variables with a significant association with survival or recurrence are shown in bold

From: Expression of a-Tocopherol-Associated protein (TAP) is associated with clinical outcome in breast cancer patients

 

5 year survival

5 year recurrence

5 year recurrence, ER+/PR±

 

HR

p

N

HR

p

N

HR

p

N

TAP

0.26 (0.08, 0.87)

0.01

264

0.35 (0.16, 0.74)

0.002

271

0.35 (0.13, 0.92)

0.02

197

Hormone therapy

0.54 (0.25, 1.2)

0.12

262

0.68 (0.38, 1.2)

0.21

261

1.8 (0.55, 6.2)

0.28

192

Chemotherapy

4.34 (1.63, 11.6)

0.001

262

2.51 (1.37, 4.6)

0.002

263

2.2 (1, 4.84)

0.05

193

Grade

4.44 (1.74, 11.3)

<0.001

230

2.3 (1.34, 3.93)

0.001

231

2.5 (1.24, 5.05)

0.007

175

Stage

3.35 (1.82, 6.16)

<0.001

264

2.71 (1.76, 4.17)

<0.001

265

2.66 (1.47, 4.83)

0.001

195

Age

0.98 (0.95, 1.01)

0.193

264

0.98 (0.97, 1)

0.054

265

0.97 (0.94, 1)

0.058

195

TAP

0.28 (0.08, 0.95)

0.04

264

0.38 (0.18, 0.81)

0.012

265

0.37 (0.14, 0.98)

0.045

195

Stage

3.25 (1.76, 6)

<0.001

2.63 (1.71, 4.06)

<0.001

2.57 (1.41, 4.69)

0.002

TAP

0.55 (0.16, 1.93)

0.35

230

0.54 (0.23, 1.24)

0.15

231

0.51 (0.19, 1.39)

0.19

174

Grade

3.93 (1.52, 10.18)

0.005

2.05 (1.19, 3.52)

0.01

2.3 (1.15, 4.59)

0.018

TAP

0.28 (0.08, 0.94)

0.039

264

0.38 (0.18, 0.82)

0.014

265

0.37 (0.14, 0.98)

0.045

195

Age

0.99 (0.96, 1.02)

0.37

0.98 (0.96, 1.01)

0.16

0.97 (0.94, 1.01)

0.097

TAP

0.27 (0.08, 0.90)

0.032

262

0.37 (0.17, 0.78)

0.0093

261

0.35 (0.13,0.93)

0.036

192

Hormone therapy

0.58 (0.27, 1.3)

0.17

0.73 (0.41, 1.3)

0.3

1.77 (0.53, 5.9)

0.35

TAP

0.34 (0.1, 1.14)

0.081

262

0.42 (0.2, 0.91)

0.027

263

0.38 (0.14, 1.01)

0.052

193

Chemotherapy

3.69 (1.37, 9.92)

0.01

2.16 (1.17, 4.01)

0.014

1.94 (0.87, 4.3)

0.1

TAP

0.33 (0.1, 1.13)

0.078

262

0.41 (0.19, 0.89)

0.023

263

0.38 (0.14, 1.03)

0.057

193

Stage

2.77 (1.42, 5.4)

0.003

2.44 (1.53, 3.9)

0

2.42 (1.27, 4.61)

0.007

Chemotherapy

2.21 (0.79, 6.17)

0.13

1.35 (0.7, 2.59)

0.37

1.23 (0.53, 2.85)

0.63

TAP

0.32 (0.1, 1.1)

0.07

262

0.41 (0.19, 0.89)

0.024

263

0.39 (0.15, 1.06)

0.065

193

Stage

2.8 (1.43, 5.47)

0.003

2.44 (1.53, 3.9)

0

2.53 (1.34, 4.76)

0.004

Chemotherapy

2.98 (0.89, 10)

0.077

1.34 (0.61, 2.94)

0.47

0.85 (0.31, 2.32)

0.75

Age

1.02 (0.98, 1.06)

0.35

1 (0.97, 1.03)

0.98

0.97 (0.94, 1.01)

0.19