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Table 2 Correlation of PIK3CA mutation status with the clinicopathological characteristics of breast cancer

From: Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer

Clinicopathological parameters

Mutated (%)

Wild type (%)

P

All Tumor Cases

64 (34.4)

122 (65.6)

NS

Histological Type

  

NS

Ductal/Other Carcinoma

53 (32.5)

110 (67.5)

Lobular Carcinoma

11 (47.8)

12 (52.2)

Tumor Stage

  

NS

T1

13 (30.2)

28 (65.1)

T2

37 (34.9)

69 (65.1)

T3

9 (42.9)

12 (57.1)

T4

5 (41.7)

7 (58.3)

Node Status

  

0.042

N0

25 (27.8)

65 (72.2)

N+

37 (42.5)

50 (57.5)

Tumor Grade

  

<0.001

G1

16 (80.0)

4 (20.0)

G2

35 (36.5)

61 (63.5)

G3

13 (18.8)

56 (81.2)

Hormone Receptor Status

  

0.002

HR+

58 (40.3)

86 (59.7)

HR-

6 (14.3)

36 (85.7)

HER2 Status

  

0.032

HER2+

3 (13.6)

19 (86.4)

HER2-

61 (37.2)

103 (62.8)

Age

  

NS

<50 years

6 (26.1)

17 (73.9)

>50 years

58 (35.6)

105 (64.4)

Molecular Type

  

0.003

HR+/HER2-

57 (42.5)

77 (57.5)

HR+/HER2+

1 (10.0)

9 (90.0)

HR-/HER2+

2 (16.7)

10 (83.3)

 

HR-/HER2-

4 (13.3)

26 (86.7)

  1. The mutation frequency, as determined by NGS, decreased with increasing tumor grade: 85 % for G1, 37 % for G2, and 20 % for G3. PIK3CA mutations were more frequently detected (42 %) in HR+ breast cancer than in HR- breast cancer (14 %). PIK3CA mutations were more frequently detected in HER2- breast cancer (38 %) than in HER2+ breast cancer (14 %)