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Table 1 Hotspots of PIK3CA mutations in breast cancer

From: Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer

Exon Mutation Number Frequency (%) Total number
1 R108del, R109del 1, 2 1.6, 3.1 3
4 N345K, N347T (new), D350N 3,1,1 4.7, 1.6, 1.6 5
7 G451_D454del (new), p.L456V (new) 1,1 1.6, 1.6 2
9 E542K, E545K, Q546K, Q546R 6, 11, 1, 1 9.4, 17.2 19
13 E726K 2 3,1 2
20 D1029H, N1044K, H1047L, H1047R, G1049R 1, 1, 3, 31, 1 1.6, 1.6, 48.4, 4.7, 1.6 37
   total: 68   
  1. Using semiconductor NGS, we identified a total of 68 non-silent mutations in 186 breast cancer samples (34.4 %). The most frequent aberrations were p.H1047R, p.E545K, and p.E542K