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Table 1 Hotspots of PIK3CA mutations in breast cancer

From: Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer

Exon

Mutation

Number

Frequency (%)

Total number

1

R108del, R109del

1, 2

1.6, 3.1

3

4

N345K, N347T (new), D350N

3,1,1

4.7, 1.6, 1.6

5

7

G451_D454del (new), p.L456V (new)

1,1

1.6, 1.6

2

9

E542K, E545K, Q546K, Q546R

6, 11, 1, 1

9.4, 17.2

19

13

E726K

2

3,1

2

20

D1029H, N1044K, H1047L, H1047R, G1049R

1, 1, 3, 31, 1

1.6, 1.6, 48.4, 4.7, 1.6

37

  

total: 68

  
  1. Using semiconductor NGS, we identified a total of 68 non-silent mutations in 186 breast cancer samples (34.4 %). The most frequent aberrations were p.H1047R, p.E545K, and p.E542K
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BMC Clinical Pathology

ISSN: 1472-6890

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