Fig. 3From: Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancerStrong association of PIK3CA status with molecular subtype and tumor grade in breast cancer. a PIK3CA mutations were more frequent in HR+/HER2- breast cancer (40Â %) compared with the other subtypes (11Â %-20Â %). b The mutation frequency decreased with increasing tumor grade: 80Â % in G1, 36Â % in G2, and 19Â % in G3Back to article page