Table 1 Association of HMGCR expression with patient characteristics
All patients median (IQR) or % | Missing | Patients with evaluable TMA | HMGCR expression-Intensity median (IQR) or % | ||||
|---|---|---|---|---|---|---|---|
No staining = 0 | Weak = 1 | Moderate/Strong = 2/3 | P-value | ||||
n= | 1026 | 885 | 113 | 555 | 217 | ||
Age at inclusion, yrs | 61.1 (52.1-68.1) | 0 | 60.9 (52.2-67.9) | 61.2 (53.7-69.2) | 60.1 (51.6-67.4) | 64.3 (53.9-69.4) | 0.004c |
Body mass index (BMI), (kg/m-2) | 25.1 (22.5-28.3) | 28 | 25.2 (22.5-28.4) | 25.7 (23.2-28.7) | 25.0 (22.4-28.3) | 25.3 (22.5-29.0) | 0.39c |
Height (cm) | 165 (162–170) | 26 | 165 (162–170) | 164 (160–169) | 166 (162–170) | 165 (161–169) | 0.03c |
Weight (kg) | 69 (62–78) | 26 | 69 (62–78) | 70 (62–79) | 69 (62–78) | 69 (61–80) | 0.91c |
Waist-Hip-Ratio | 0.86 (0.81-0.9) | 38 | 0.86 (0.81-0.90) | 0.86 (0.81-0.92) | 0.85 (0.80-0.90) | 0.86 (0.81-0.90) | 0.32c |
Waist (cm) | 87 (79–97) | 38 | 87 (80–97) | 89 (82–97) | 87 (79–97) | 89 (80–98) | 0.24c |
Hip (cm) | 102 (97–109) | 38 | 102 (97–109) | 104 (99–109) | 102 (97–109) | 102 (96–111) | 0.57c |
Breast volume (ml) | 1000 (650–1500) | 161 | 1000 (650–1550) | 1000 (700–1550) | 950 (640–1500) | 1000 (656–1600) | 0.28c |
Age at menarche, yrs | 13 (12–14) | 7 | 13 (12–14) | 13 (13–14) | 13 (12–14) | 13 (12–14) | 0.68c |
Nulliparous | 124 (12.1 %) | 1 | 109 (12.3 %) | 17 (15.0 %) | 67 (12.1 %) | 25 (11.5 %) | 0.41d |
Parity | 2 (1–3) | 1 | 2 (1–3) | 2 (1–3) | 2 (1–3) | 2 (1–2) | 0.46c |
Age at first child, years* | 25 (22–28) | 6 | 24 (22–28) | 24 (21–27) | 25 (21–28) | 25 (22–29) | 0.09b |
Ever use of HRT | 449 (43.9 %) | 3 | 386 (43.8 %) | 55 (48.7 %) | 231 (41.8 %) | 100 (43.8 %) | 0.28a |
Ever oral contraceptives | 726 (70.8 %) | 1 | 625 (70.7 %) | 82 (72.6 %) | 394 (71.1 %) | 149 (68.7 %) | 0.42d |
Current smoker | 210 (20.5 %) | 2 | 177 (20.0 %) | 26 (23.0 %) | 111 (20.1 %) | 40 (18.4 %) | 0.34d |
Coffee, 2+ cups per day | 832 (81.4 %) | 4 | 708 (80.4 %) | 89 (78.8 %) | 448 (81.3 %) | 171 (78.8 %) | 0.66a |
Alcohol abstainer | 107 (10.5 %) | 7 | 96 (10.9 %) | 15 (13.3 %) | 56 (10.1 %) | 25 (11.6 %) | 0.58a |