SOD2 immunoexpression predicts lymph node metastasis in penile cancer

BMC Clinical Pathology

Table 5 Distribution of patients according to the combination of the predictive factors of inguinal lymph node metastasis found in the multivariate model

Palpable suspicious lymph node	Tumor depth	Perineural invasion	SOD2 expression (>50%)	Patients at risk	Patients with inguinal lymph node metastasis
Palpable suspicious lymph node	Tumor depth	Perineural invasion	SOD2 expression (>50%)	n	n	(%)
No (*1)	≤5 mm	Absent	-	9	0	(0.0)
		Absent	+	4	0	(0.0)
		Present	-	2	0	(0.0)
		Present	+	0	NA	NA
	>5 mm	Absent	-	15	2	(13.3)
		Absent	+	10	2	(20.0)
		Present	-	2	0	(0.0)
		Present	+	7	5	(71.4)
Yes (*2)	≤5 mm	Absent	-	2	0	(0.0)
		Absent	+	0	NA	NA
		Present	-	1	0	(0.0)
		Present	+	2	2	(100.0)
	>5 mm	Absent	-	19	7	(36.8)
		Absent	+	12	8	(66.7)
		Present	-	7	7	(100.0)
		Present	+	12	11	(91.7)
All cases (*3)	≤5 mm	Absent	-	11	0	(0.0)
		Absent	+	4	0	(0.0)
		Present	-	3	0	(0.0)
		Present	+	2	2	(100.0)
	>5 mm	Absent	-	34	9	(26.5)
		Absent	+	24	10	(41.7)
		Present	-	9	7	(77.8)
		Present	+	19	16	(84.2)

NA: Data not available since any case was observed in this situation.
(*1) Eight cases were not included in this group because they did have either tumor depth or perineural information. SOD2 expression was positive in three of them. All those cases had no lymph node metastasis.
(*2) Four cases were not included in this group because they did have either tumor depth or perineural information. SOD2 expression was positive in one of them. All those cases had no lymph node metastasis.
(*3) Two cases with unknown clinical status of inguinal nodes were included in this group. Both cases had tumor depth > 5 mm, no perineural invasion, positive SOD2 expression and no lymph node metastasis.

ISSN: 1472-6890