Table 3 Number and percentage of cases with and without regional lymph node metastasis according to clinical and pathological variables
From: SOD2 immunoexpression predicts lymph node metastasis in penile cancer
| No lymph node metastasis | Lymph node metastasis | |||||
|---|---|---|---|---|---|---|
| Variable | Category | N | (%) | N | (%) | P value |
| Age | < 50 yo | 26 | (65.0) | 14 | (35.0) | 0.682 |
| 50 – 59 yo | 27 | (65.9) | 14 | (34.1) | ||
| ≥60 yo | 21 | (56.8) | 16 | (43.2) | ||
| Palpable suspicious regional | No | 48 | (84.2) | 9 | (15.8) | <0.001 |
| Lymph node | Yes | 24 | (40.7) | 35 | (59.3) | |
| pT (TNM) | pT1a | 7 | (100.0) | 0 | (0.0) | 0.045 |
| > pT1a | 67 | (60.4) | 44 | (39.6) | ||
| Pattern of invasion | Pushing | 6 | (46.2) | 7 | (53.8) | 0.368 |
| Infiltrating | 60 | (61.9) | 37 | (38.1) | ||
| Histological grade | Grade 1 | 13 | (86.7) | 2 | (13.3) | 0.013 |
| Grade 2 | 30 | (71.4) | 12 | (28.6) | ||
| Grade 3 | 31 | (50.8) | 30 | (49.2) | ||
| Perineural invasion | No | 59 | (75.6) | 19 | (24.4) | <0.001 |
| Yes | 9 | (26.5) | 25 | (73.5) | ||
| Vascular invasion | No | 55 | (68.8) | 25 | (31.2) | 0.010 |
| Yes | 13 | (40.6) | 19 | (59.4) | ||
| Invasion of corpora cavernous | No | 14 | (66.7) | 7 | (33.3) | 0.303 |
| Yes | 28 | (50.9) | 27 | (49.1) | ||
| Invasion of corpora spongiosum | No | 3 | (75.0) | 1 | (25.0) | 1.000 |
| Yes | 50 | (60.2) | 33 | (39.8) | ||
| Invasion of urethra | No | 26 | (66.7) | 13 | (33.3) | 0.436 |
| Yes | 14 | (56.0) | 11 | (44.0) | ||
| Tumor depth | ≤5 mm | 18 | (90.0) | 2 | (10.0) | 0.002 |
| >5 mm | 44 | (51.2) | 42 | (48.8) | ||
| HPV-16 | No | 64 | (62.1) | 39 | (37.9) | 1.000 |
| Yes | 10 | (66.7) | 5 | (33.3) | ||
| HPV-18 | No | 68 | (61.3) | 43 | (38.7) | 0.255 |
| Yes | 6 | (85.7) | 1 | (14.3) | ||
| SOD2 expression | <50% | 49 | (75.4) | 16 | (24.6) | 0.002 |
| >50% | 25 | (47.2) | 28 | (52.8) | ||