Table 3 Number and percentage of cases with and without regional lymph node metastasis according to clinical and pathological variables

Age

< 50 yo

26

(65.0)

14

(35.0)

0.682

50 – 59 yo

27

(65.9)

14

(34.1)

≥60 yo

21

(56.8)

16

(43.2)

Palpable suspicious regional

No

48

(84.2)

9

(15.8)

<0.001

Lymph node

Yes

24

(40.7)

35

(59.3)

pT (TNM)

pT1a

7

(100.0)

0

(0.0)

0.045

> pT1a

67

(60.4)

44

(39.6)

Pattern of invasion

Pushing

6

(46.2)

7

(53.8)

0.368

Infiltrating

60

(61.9)

37

(38.1)

Histological grade

Grade 1

13

(86.7)

2

(13.3)

0.013

Grade 2

30

(71.4)

12

(28.6)

Grade 3

31

(50.8)

30

(49.2)

Perineural invasion

No

59

(75.6)

19

(24.4)

<0.001

Yes

9

(26.5)

25

(73.5)

Vascular invasion

No

55

(68.8)

25

(31.2)

0.010

Yes

13

(40.6)

19

(59.4)

Invasion of corpora cavernous

No

14

(66.7)

7

(33.3)

0.303

Yes

28

(50.9)

27

(49.1)

Invasion of corpora spongiosum

No

3

(75.0)

1

(25.0)

1.000

Yes

50

(60.2)

33

(39.8)

Invasion of urethra

No

26

(66.7)

13

(33.3)

0.436

Yes

14

(56.0)

11

(44.0)

Tumor depth

≤5 mm

18

(90.0)

2

(10.0)

0.002

>5 mm

44

(51.2)

42

(48.8)

HPV-16

No

64

(62.1)

39

(37.9)

1.000

Yes

10

(66.7)

5

(33.3)

HPV-18

No

68

(61.3)

43

(38.7)

0.255

Yes

6

(85.7)

1

(14.3)

SOD2 expression

<50%

49

(75.4)

16

(24.6)

0.002

>50%

25

(47.2)

28

(52.8)