Figure 1

Gene expression profiling of 22 ccRCC and 9 chRCC. (A) Dendrogram of unsupervised hierarchical cluster analysis of the 31 samples with chRCC in red and subtypes I, II, III, IV, and V of ccRCC identified previously in orange, yellow, pink, blue and purple, respectively. (B) Dendrogram of supervised cluster analysis with list of genes identified by SAM procedure as being differentially expressed between ccRCC and chRCC. (C) Image of supervised cluster analysis with each row representing a single gene and each column a patient sample. The degree of color saturation corresponds to the ratio of gene expression in each sample compared to the mean expression across all samples. (D) Genes whose expression levels were determined using RCC TMA and for which scoring was performed. (E) Genes whose expression levels were determined using titering TMA or RCC TMA and for which scoring was not performed.