Table 3 The level of protein expression of different studied markers in normal, dysplastic and neoplastic cervical epithelium detected by immunohistochemistry
From: The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma
Marker | NCT (20) | CINI (n = 18) | CINII (n = 11) | CINIII (n = 38) | ISCC (n = 43) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Pos. Cases | PI* | Pos. cases | PI | Pos. cases | PI | Pos. cases | PI | Pos. cases | PI |
Ki-67 | 5 (25%) | < 0.1 |  | 6.5 ± 0.5 |  | 10 ± 0.45 |  | 21.6 ± 9 |  | 40.5 ± 11 |
Cyclin D1 | 0(0%) |  | 0(0%) |  | 0 (0%) |  | 5(13.1%) | 24.7 ± 3.6 | 18(41.9%) | 63.2 ± 10.8 |
Cyclin E | 0(0%) |  | 3(16.7%) | 18 ± 1.1 | 4(36.4%) | 30 ± 4.4 | 21(55.3%) | 60 ± 10.2 | 38(88.4%) | 97 ± 13.8 |
CDK4 | 0(0%) |  | 2(11.1%) | 5 ± 0.5 | 4(36.4%) | 12 ± 1.7 | 17(44.7%) | 35 ± 4.6 | 40(93%) | 92 ± 14.7 |
p53 | 0(0%) |  | 0(0%) |  | 0(0%) |  | 7(18.4%) | 44 ± 5.6 | 19(44.2%) | 76 ± 9.1 |
p21 waf 1 | 3(15%) | 2.8 ± 0.2 | 1(5.5%) | 7 ± 0.5 | 1(9.1%) | 9.2 | 16(42.1%) | 58 ± 7.1 | 29(67.4%) | 89 ± 10.6 |
mdm-2 | 0(0%) |  | 0(0%) |  | 0(0%) |  | 9(23.7%) | 66 ± 8.2 | 22(51.2%) | 89 ± 10 |
p27 KIP 1 | 20(100%) | 90 ± 8.6 | 18(100%) | 77 ± 10.5 | 7(63.6%) | 60 ± 11.7 | 10(26.3%) | 20 ± 5.5 | 6(13.9%) | 9 ± 1.1 |
p16 INK 4A | 0(0%) |  | 0(0%) |  | 4(36.4%) | 24 ± 4.7 | 24(63.1%) | 70 ± 12.6 | 40(93%) | 98 ± 12.0 |
Rb†| 0 | 74 ± 11.6 | 0 | 68 ± 11.1 | 6(54.5%) | 54 ± 8.6 | 21(55.2%) | 25 ± 1.6 | 29 (67.4%) | 7 ± 1.0 |