The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma

BMC Clinical Pathology

Table 1 Clinicopathologic features of invasive squamous cell carcinoma cases in relation to different studied markers.

Clinical features	No. = 43	Cyclin D1 n = 18	Cyclin E n = 38	Cdk-4 n = 40	P27 ^{KIp 1} n = 37	P53 n = 19	mdm2 n = 22	P21 ^waf n = 29	Rb n = 30	P16 n = 40	Ki-67 n = 36
Tumor size
<4 cm	15	2	10	12	9	2	4	7	13	13	10
≤4 cm	28	16	28	28	28	17	18	22	27	17	26
		( p = 0.003)	( p = 0.003)		p = 0.047	p = 0.003	p = 0.003	( p = 0.001)			( p = 0.008)
Tumor type
LK-SCC	13	7	9	13	7	1	3	10	12	2	8
LNK-SCC	26	10	25	24	26	15	16	17	24	24	24
SmCC	4	1	4	3	4	3	3	2	3	4	4
					p = 0.047	p = 0.01	p = 0.01
Stromal invasion
<1/2	15	6	13	15	12	7	7	9	9	14	12
≤1/2	28	12	25	25	25	12	15	20	21	26	24
					p = 0.024			p = 0.037
Lymph nodes
Positive	13	5	9	11	7	2	4	10	7	11	7
Negative	30	13	29	29	30	17	18	19	23	29	29
					p = 0.001						p = 0.001
Lympho- vascular
Positive	7	5	5	5	4	2	2	5	4	5	6
Negative	36	13	33	35	33	17	20	24	26	35	30
					p = 0.035	p = 0.003	p = 0.001
Vaginal involvement
Positive	12	6	10	10	7	5	3	8	9	10	11
Negative	31	12	28	30	30	14	19	21	21	30	25
								( p = 0.037)
FIGO Stage
I&II	17	3	15	16	12	2	9	12	13	17	10
III&IV	26	15	23	24	25	17	13	17	17	23	26
		( p = 0.008)			p = 0.002	p = 0.003					p = 0.019

* LNK-SCC: Large non-keratinized squamous cell carcinoma LNK-SCC: Large keratinized squamous cell carcinoma SmCC: Small cell carcinoma

ISSN: 1472-6890