Figure 1
From: The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma
a) Positive immunostaining for p27 KIP 1 i n the nuclei of normal cervical tissue, b) positive immunostaining for p27 KIP 1in CINI, c) lack of p27 KIP 1immunostaining in a case of invasive squamous cell carcinoma, d) positive immunostaining for p16 INK 4Ain a case of CINII, e) positive immunostaining for p16 INK 4Ain a case of III, f) negative nuclear imminostaining for cyclinD1 in normal cervical tissue except in the parabasal cells, g) a strongly positive immunostaining for cyclinD1 in a case of invasive squamous cell carcinoma, h) positive nuclear immunostaining for Rb in parabasal and intermediate squamous cells in hyperplastic squamous epithelium, and i) focal and weak nuclear staining for Rb in a case of invasive squamous cell carcinoma.