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Table 4 Unstimulated (UPS) and stimulated (SPS) parotid salivary flow rates, composition including pH, PCO2, buffer capacity, degree of saturation with regard to hydroxyapatite, and critical pH in the patients with primary Sjögren's syndrome (pSS, (n = 20)) and the healthy controls (n = 20). Results are given in medians (range).

From: Salivary changes and dental caries as potential oral markers of autoimmune salivary gland dysfunction in primary Sjögren's syndrome

 

UPS

 

SPS

 
 

pSS

Healthy controls

P-value

pSS

Healthy controls

P-value

Flow rate (ml/min/gland)

0.00* (0.00–0.04) (n = 20)

0.04 (0.00–0.13) (n = 20)

<0.001

0.10 (0.00–0.87) (n = 20)

0.72 (0.17–1.57) (n = 20)

<0.001

pH

5.5 (4.9–6.2) (n = 7)

6.1 (5.4–6.6) (n = 14)

0.008

6.8 (5.3–7.6) (n = 13)

7.1 (6.8–8.0) (n = 19)

0.020

PCO2 (KPa)

2.5 (2.1–4.8) (n = 7)

3.3 (0.5–7.9) (n = 14)

0.455

3.5 (1.4–7.5) (n = 13)

5.5 (0.3–10.0) (n = 19)

0.021

Na+ (mM)

7.0 (0.0–111.0) (n = 9)

0.0 (0.0–8.5) (n = 19)

0.002

15.5 (3.5–93.0) (n = 15)

7.5 (0.0–65.0) (n = 20)

0.034

K+ (mM)

24.5 (4.5–52.5) (n = 9)

29.0 (17.5–62.0) (n = 19)

0.209

26.5 (12.0–53.0) (n = 15)

23.0 (18.0–40.0) (n = 20)

0.689

Total calcium (mM)

1.0 (0.4–2.4) (n = 9)

1.0 (0.6–4.1) (n = 16)

0.887

1.1 (0.6–1.8) (n = 13)

0.8 (0.4–1.4) (n = 20)

0.008

Cl- (mM)

22.5 (5.0–100.5) (n = 9)

19.0 (12.0–43.0) (n = 19)

0.588

27.0 (12.5–94.0) (n = 14)

15.5 (9.0–59.0) (n = 20)

0.037

Bicarbonate (mM)

0.2 (0.0–0.8) (n = 8)

0.8 (0.1–3.5) (n = 14)

0.017

3.6 (0.1–26.8) (n = 12)

11.3 (3.8–43.9) (n = 19)

0.025

Total phosphate (mM)

5.6 (2.3–15.0) (n = 7)

9.3 (4.1–18.9) (n = 16)

0.066

6.1 (2.1–8.2) (n = 11)

5.2 (3.2–16.9) (n = 20)

0.577

Total protein (mg/ml)

1.11 (0.47–8.97) (n = 9)

2.02 (0.64–5.34) (n = 18)

0.316

1.33 (0.62–6.66) (n = 14)

1.60 (0.84–4.19) (n = 20)

0.589

Total protein output (mg/min)

0 (0–0.18) (n = 9)

0.07 (0–0.30) (n = 18)

<0.001

0.13 (0–1.38) (n = 14)

1.30 (0.29–5.42) (n = 20)

<0.001

Amylase activity (μkat/l)

7760 (3700–21200)

(n = 7)

5815 (1670–27140)

(n = 18)

0.193

5220 (560–17240)

(n = 13)

5520 (710–14710)

(n = 20)

0.624

β(mmol H+/l. pH unit)

1.2 (0.1–2.9) (n = 7)

4.0 (2.3–8.9) (n = 13)

<0.001

4.4 (0.5–6.7) (n = 10)

5.2 (0.7–10.1) (n = 19)

0.171

DSHAP

1.4 (0.2–3.6) (n = 9)

3.1 (2.5–10.4) (n = 16)

0.001

7.3 (0.6–21.4) (n = 13)

10.0 (4.5–22.0) (n = 19)

0.372

Critical pH

5.4 (5.1–6.2) (n = 7)

5.3 (5.0–5.5) (n = 16)

0.413

5.5 (5.2–6.2) (n = 11)

5.7 (5.2–5.8) (n = 19)

0.611

  1. The buffer capacity (β) was calculated from the bicarbonate and phosphate concentrations individually for each saliva sample at its pH value, DSHAP denotes the degree of saturation with regard to hydroxyapatite. P-value obtained by a Wilcoxon's rank sum test. * corresponds to mean value below 0.01 ml/min.