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Table 2 Peripheral blood leukocyte and neutrophil counts in WT and P/I null mice subjected to CLP and 2% glycogen-induced peritonitis. Control group represents normal mice that were not subjected to sham or peritonitis treatment. Sham (CLP) represents the CLP respective sham group. Data are expressed as mean ± SEM, representing the absolute number of cells X 106. * p ≤ 0.05 compared to respective control group; # p ≤ 0.05 wild-type compared to P/I null mice at the same time point and treatment. n represents the number of mice per each group.

From: Gene deletion of P-Selectin and ICAM-1 does not inhibit neutrophil infiltration into peritoneal cavity following cecal ligation-puncture

Experimental design

WT mice Total Leukocytes (× 106 /mL)

P/I null mice Total Leukocytes (× 106 /mL)

WT mice Neutrophils (× 106 /mL)

P/I null mice Neutrophils (× 106 /mL)

Control (n = 4)

10.1 ± 1.3

10.3 ± 2.1

2.8 ± 0.7 #

6.7 ± 1.3

Sham (CLP) 6 hr (n = 4)

3.6 ± 0.6 *

4.5 ± 0.3 *

2.2 ± 0.1 #

3.8 ± 0.5

Sham (CLP) 24 hr (n = 6)

2.9 ± 0.7 *

4.4 ± 0.8 *

1.4 ± 0.3 *

2.3 ± 0.1 *

CLP 6 hr (n = 6)

2.0 ± 0.4 *

3.4 ± 0.9 *

1.2 ± 0.3 *

2.8 ± 0.9 *

CLP 24 hr (n = 6)

1.1 ± 0.3 *

3.8 ± 1.1 *

0.6 ± 0.2 *

2.8 ± 0.8 *

2% Glycogen 6 hr (n = 4)

3.4 ± 0.1 *

4.4 ± 0.8 *

2.5 ± 0.1

3.6± 0.6

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BMC Clinical Pathology

ISSN: 1472-6890

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